Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /DUF1778(antitoxin) |
| Location | 781576..782528 | Replicon | chromosome |
| Accession | NZ_CP034673 | ||
| Organism | Vibrio anguillarum strain J360 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A7U5NDE7 |
| Locus tag | DYL72_RS19795 | Protein ID | WP_069211914.1 |
| Coordinates | 781576..782109 (-) | Length | 178 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | DYL72_RS22035 | Protein ID | WP_164732805.1 |
| Coordinates | 782106..782528 (-) | Length | 141 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DYL72_RS19760 | 777193..777564 | + | 372 | WP_013867787.1 | DUF3319 domain-containing protein | - |
| DYL72_RS19765 | 777572..777883 | + | 312 | WP_019282715.1 | stress response translation initiation inhibitor YciH | - |
| DYL72_RS19770 | 778153..778437 | - | 285 | WP_069212144.1 | hypothetical protein | - |
| DYL72_RS19775 | 778434..778643 | - | 210 | WP_194568891.1 | hypothetical protein | - |
| DYL72_RS19785 | 779982..780392 | + | 411 | Protein_719 | IS30 family transposase | - |
| DYL72_RS19790 | 780450..781370 | - | 921 | WP_069211915.1 | hypothetical protein | - |
| DYL72_RS19795 | 781576..782109 | - | 534 | WP_069211914.1 | GNAT family N-acetyltransferase | Toxin |
| DYL72_RS22035 | 782106..782528 | - | 423 | WP_164732805.1 | DUF1778 domain-containing protein | Antitoxin |
| DYL72_RS19815 | 782880..783073 | - | 194 | Protein_723 | IS4 family transposase | - |
| DYL72_RS19820 | 783134..784209 | + | 1076 | Protein_724 | IS3 family transposase | - |
| DYL72_RS19825 | 784283..785460 | + | 1178 | WP_095661382.1 | IS3 family transposase | - |
| DYL72_RS19835 | 785923..786894 | + | 972 | WP_019282910.1 | IS110 family transposase | - |
| DYL72_RS19840 | 786908..787348 | - | 441 | WP_029190018.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 776131..799440 | 23309 | |
| - | inside | IScluster/Tn | - | - | 778767..807955 | 29188 | |
| - | inside | Integron | - | - | 780450..782601 | 2151 | |
| - | inside | Integron | - | - | 786908..802534 | 15626 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 178 a.a. Molecular weight: 20293.67 Da Isoelectric Point: 9.3517
>T116361 WP_069211914.1 NZ_CP034673:c782109-781576 [Vibrio anguillarum]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKRMQAGISRTMVLPSAQPLLNQKFAICVFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEYHGSGLGKISLIRALKYLWEVNHHMRVYAIVVDCLTDSAQAFYTKFGFEVLCEYNE
RIRMFLPMKTVEQLFNQ
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKRMQAGISRTMVLPSAQPLLNQKFAICVFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEYHGSGLGKISLIRALKYLWEVNHHMRVYAIVVDCLTDSAQAFYTKFGFEVLCEYNE
RIRMFLPMKTVEQLFNQ
Download Length: 534 bp
>T116361 NZ_CP034673:c782109-781576 [Vibrio anguillarum]
GTGAGTTGGGGTAAAGAGTTTGTAGAACTTAGTAAGTCAAAGCATGACCGCGATTCATTTGACTGTGGAGAGCAAGAGCT
AAACACATTTATCAAAACTCAAGCTGCAAAGCGCATGCAAGCAGGTATTAGCCGAACAATGGTTTTACCTAGTGCTCAAC
CACTGTTAAATCAAAAATTCGCTATTTGTGTATTTTATAGTGTTGCACCGAGTTCAATCAGTCGAGAAACATTGCCGGCA
CAACTAGCAAAGAAACTTCCTAGGTATCCAATCCCTGTTTTTCTTTTGGCTCAATTAGCTGTGCACAAAGAGTATCATGG
CTCTGGGCTCGGAAAAATTAGTCTAATTCGCGCACTGAAGTACTTATGGGAAGTGAATCATCACATGAGGGTATACGCAA
TAGTTGTGGACTGTCTGACAGATTCCGCTCAAGCGTTCTATACGAAGTTTGGCTTTGAAGTATTGTGCGAATATAATGAG
CGTATTCGTATGTTCTTACCAATGAAAACGGTAGAACAGCTTTTTAATCAATAG
GTGAGTTGGGGTAAAGAGTTTGTAGAACTTAGTAAGTCAAAGCATGACCGCGATTCATTTGACTGTGGAGAGCAAGAGCT
AAACACATTTATCAAAACTCAAGCTGCAAAGCGCATGCAAGCAGGTATTAGCCGAACAATGGTTTTACCTAGTGCTCAAC
CACTGTTAAATCAAAAATTCGCTATTTGTGTATTTTATAGTGTTGCACCGAGTTCAATCAGTCGAGAAACATTGCCGGCA
CAACTAGCAAAGAAACTTCCTAGGTATCCAATCCCTGTTTTTCTTTTGGCTCAATTAGCTGTGCACAAAGAGTATCATGG
CTCTGGGCTCGGAAAAATTAGTCTAATTCGCGCACTGAAGTACTTATGGGAAGTGAATCATCACATGAGGGTATACGCAA
TAGTTGTGGACTGTCTGACAGATTCCGCTCAAGCGTTCTATACGAAGTTTGGCTTTGAAGTATTGTGCGAATATAATGAG
CGTATTCGTATGTTCTTACCAATGAAAACGGTAGAACAGCTTTTTAATCAATAG
Antitoxin
Download Length: 141 a.a. Molecular weight: 15816.26 Da Isoelectric Point: 6.4738
>AT116361 WP_164732805.1 NZ_CP034673:c782528-782106 [Vibrio anguillarum]
VYFLSSAVRWQPLSRALYSLSFRKFSVLIEYALSLHYNQSAYGTYPYIGGVMATARLDIRLDEEIKAKAEKASALLGLKS
LTEYVVRLMDEDATHVIEEYESIMVKDSVFDEFMAACNKVKAPNQALLEAVKFTEKSGIK
VYFLSSAVRWQPLSRALYSLSFRKFSVLIEYALSLHYNQSAYGTYPYIGGVMATARLDIRLDEEIKAKAEKASALLGLKS
LTEYVVRLMDEDATHVIEEYESIMVKDSVFDEFMAACNKVKAPNQALLEAVKFTEKSGIK
Download Length: 423 bp
>AT116361 NZ_CP034673:c782528-782106 [Vibrio anguillarum]
GTGTATTTTTTGAGTTCGGCGGTGCGTTGGCAACCCCTTAGCCGGGCGTTATACTCTCTCTCGTTCCGTAAATTTTCTGT
ACTAATTGAATATGCCTTAAGTTTGCACTATAATCAATCAGCTTACGGAACATATCCGTACATTGGAGGGGTTATGGCAA
CGGCACGTTTAGATATCCGCCTTGATGAAGAGATCAAGGCAAAAGCCGAAAAAGCATCGGCTTTACTTGGTTTAAAAAGT
CTCACTGAATATGTAGTGAGACTTATGGACGAAGATGCGACTCATGTTATTGAGGAGTATGAAAGTATTATGGTTAAAGA
CAGTGTTTTTGACGAATTTATGGCTGCGTGTAATAAAGTAAAAGCACCGAATCAAGCTTTGCTTGAAGCTGTTAAATTTA
CAGAGAAGAGTGGTATCAAGTGA
GTGTATTTTTTGAGTTCGGCGGTGCGTTGGCAACCCCTTAGCCGGGCGTTATACTCTCTCTCGTTCCGTAAATTTTCTGT
ACTAATTGAATATGCCTTAAGTTTGCACTATAATCAATCAGCTTACGGAACATATCCGTACATTGGAGGGGTTATGGCAA
CGGCACGTTTAGATATCCGCCTTGATGAAGAGATCAAGGCAAAAGCCGAAAAAGCATCGGCTTTACTTGGTTTAAAAAGT
CTCACTGAATATGTAGTGAGACTTATGGACGAAGATGCGACTCATGTTATTGAGGAGTATGAAAGTATTATGGTTAAAGA
CAGTGTTTTTGACGAATTTATGGCTGCGTGTAATAAAGTAAAAGCACCGAATCAAGCTTTGCTTGAAGCTGTTAAATTTA
CAGAGAAGAGTGGTATCAAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|