Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-YefM
Location 675948..676497 Replicon chromosome
Accession NZ_CP034673
Organism Vibrio anguillarum strain J360

Toxin (Protein)


Gene name parE Uniprot ID A0A191WAE5
Locus tag DYL72_RS19250 Protein ID WP_017049509.1
Coordinates 675948..676247 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A233HQC6
Locus tag DYL72_RS19255 Protein ID WP_017045808.1
Coordinates 676255..676497 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DYL72_RS19215 671638..672018 + 381 Protein_607 GNAT family N-acetyltransferase -
DYL72_RS19220 672037..673005 - 969 WP_081245537.1 IS30 family transposase -
DYL72_RS19225 673190..673456 + 267 WP_081245529.1 dihydrofolate reductase family protein -
DYL72_RS19230 673591..674106 + 516 WP_029388222.1 lipocalin family protein -
DYL72_RS19235 674247..674720 + 474 WP_019282174.1 GNAT family N-acetyltransferase -
DYL72_RS19240 674711..674827 + 117 Protein_612 DUF3265 domain-containing protein -
DYL72_RS19245 675316..675780 + 465 WP_017046620.1 GNAT family N-acetyltransferase -
DYL72_RS19250 675948..676247 - 300 WP_017049509.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DYL72_RS19255 676255..676497 - 243 WP_017045808.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DYL72_RS19260 676740..677890 + 1151 WP_095661212.1 IS3 family transposase -
DYL72_RS19265 677920..678000 + 81 Protein_617 anaerobic ribonucleoside-triphosphate reductase-activating protein -
DYL72_RS19270 678063..679244 + 1182 WP_019282469.1 aspartate/tyrosine/aromatic aminotransferase -
DYL72_RS19275 679273..679893 + 621 WP_019282470.1 ATP-dependent zinc protease -
DYL72_RS19280 680209..681156 + 948 WP_038148427.1 exopolyphosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 637327..677890 40563


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-47)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11412.09 Da        Isoelectric Point: 9.8456

>T116360 WP_017049509.1 NZ_CP034673:c676247-675948 [Vibrio anguillarum]
MHKSKYKLSKLAQAHLHKIKNYTVTNFSEMQWNAYKDTLLTGFQMLADNPAVGRSCNDLYQNGFYFPIGKHTAYFTKEDS
FILVVAVLGQSQLPQNHLR

Download         Length: 300 bp

>T116360 NZ_CP034673:c676247-675948 [Vibrio anguillarum]
ATGCACAAGAGTAAATATAAACTAAGTAAATTAGCACAGGCTCATTTACATAAAATCAAAAATTATACCGTTACAAACTT
TTCCGAGATGCAGTGGAACGCATACAAAGACACTCTTCTTACTGGGTTTCAGATGCTCGCTGACAACCCCGCTGTAGGCA
GAAGCTGCAACGATTTATATCAAAATGGTTTTTACTTCCCTATAGGCAAGCATACGGCTTACTTTACCAAGGAAGACAGT
TTTATTTTGGTCGTTGCAGTCCTTGGGCAATCGCAATTGCCACAAAACCATCTGCGATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9036.28 Da        Isoelectric Point: 4.7672

>AT116360 WP_017045808.1 NZ_CP034673:c676497-676255 [Vibrio anguillarum]
MYTLTANDAKRNFGELLLNAQREPVKISKNNKDAVVVMSIRDYEELEVMKADYIKHCFESAKADLAQGNIVDGENFLNAL

Download         Length: 243 bp

>AT116360 NZ_CP034673:c676497-676255 [Vibrio anguillarum]
ATGTACACATTAACAGCAAATGATGCCAAACGTAATTTCGGTGAACTGCTTCTAAACGCTCAACGTGAGCCAGTTAAAAT
TAGTAAAAACAATAAAGATGCCGTTGTTGTGATGTCGATTAGAGACTATGAAGAACTTGAAGTCATGAAAGCCGATTACA
TAAAACATTGTTTTGAGTCCGCAAAAGCAGACTTAGCCCAAGGCAATATAGTTGACGGTGAAAACTTCCTAAACGCGTTG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A191WAE5

Antitoxin

Source ID Structure
AlphaFold DB A0A233HQC6

References