Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 617959..618469 Replicon chromosome
Accession NZ_CP034673
Organism Vibrio anguillarum strain J360

Toxin (Protein)


Gene name relB Uniprot ID A0A289GH26
Locus tag DYL72_RS18810 Protein ID WP_009836584.1
Coordinates 618206..618469 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A7T0WJM7
Locus tag DYL72_RS18805 Protein ID WP_019283323.1
Coordinates 617959..618213 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DYL72_RS18765 612985..613401 + 417 WP_017045395.1 VOC family protein -
DYL72_RS18770 613414..614385 - 972 WP_019282910.1 IS110 family transposase -
DYL72_RS18780 614718..614951 + 234 WP_116285044.1 hypothetical protein -
DYL72_RS18785 614958..615311 - 354 Protein_544 transposase -
DYL72_RS18790 615395..615715 + 321 WP_081245520.1 IS66 family insertion sequence hypothetical protein -
DYL72_RS18795 615712..616065 + 354 WP_069212062.1 IS66 family insertion sequence element accessory protein TnpB -
DYL72_RS18800 616125..617657 + 1533 WP_069212063.1 IS66-like element ISVa9 family transposase -
DYL72_RS18805 617959..618213 + 255 WP_019283323.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
DYL72_RS18810 618206..618469 + 264 WP_009836584.1 Txe/YoeB family addiction module toxin Toxin
DYL72_RS18820 618760..619728 - 969 WP_095661356.1 IS30 family transposase -
DYL72_RS18830 619827..620000 + 174 Protein_551 GNAT family N-acetyltransferase -
DYL72_RS18835 620008..620979 - 972 WP_019282910.1 IS110 family transposase -
DYL72_RS18840 621200..621292 + 93 WP_140286978.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 610176..632066 21890
- inside Integron - - 592798..625119 32321


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10302.63 Da        Isoelectric Point: 8.8578

>T116359 WP_009836584.1 NZ_CP034673:618206-618469 [Vibrio anguillarum]
MSSRLLSWTDESWNDYVYWQTQDKKTLKRINKLITDAKRSPFEGIGKPEPLKENLSGFWSRRIDDANRLVYAVDDSAITI
ISCRYHY

Download         Length: 264 bp

>T116359 NZ_CP034673:618206-618469 [Vibrio anguillarum]
ATGAGTAGTCGTTTATTATCTTGGACTGATGAATCTTGGAATGATTATGTTTATTGGCAGACGCAAGACAAGAAAACACT
TAAACGTATAAATAAACTCATCACGGATGCTAAGCGTTCTCCTTTCGAGGGCATAGGTAAACCTGAGCCACTAAAAGAAA
ACTTATCTGGTTTTTGGTCGCGACGAATAGACGATGCGAATAGGTTAGTTTATGCGGTTGATGATAGTGCTATCACGATT
ATTTCTTGCCGTTATCACTATTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9434.60 Da        Isoelectric Point: 5.5802

>AT116359 WP_019283323.1 NZ_CP034673:617959-618213 [Vibrio anguillarum]
MRIVSFTEARNSLKSVLDAVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPANAEHLHRSIAQFKAGKASQRD
LIDE

Download         Length: 255 bp

>AT116359 NZ_CP034673:617959-618213 [Vibrio anguillarum]
ATGAGAATTGTATCTTTTACAGAAGCTAGAAATAGCTTGAAGAGCGTTTTGGATGCTGTTGTTAATGACGCAGATACAAC
CGTGATCACACGTCGTGATTCTGAAGATGCCGTTGTTATGTCACTGGATTATTACAATAGCTTAATGGAAACGGTTCATT
TACTTCGTTCTCCGGCAAATGCTGAGCACTTACATCGTTCAATTGCTCAATTTAAAGCGGGTAAGGCGAGCCAAAGAGAT
TTAATCGATGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A289GH26

Antitoxin

Source ID Structure
AlphaFold DB A0A7T0WJM7

References