Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 590956..591494 Replicon chromosome
Accession NZ_CP034673
Organism Vibrio anguillarum strain J360

Toxin (Protein)


Gene name parE Uniprot ID A0A7X8U0Q7
Locus tag DYL72_RS18560 Protein ID WP_019282621.1
Coordinates 590956..591255 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A289GHF4
Locus tag DYL72_RS18565 Protein ID WP_019282620.1
Coordinates 591252..591494 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DYL72_RS18535 586276..587478 + 1203 WP_029388116.1 DUF3800 domain-containing protein -
DYL72_RS18540 587672..589204 - 1533 WP_069212063.1 IS66-like element ISVa9 family transposase -
DYL72_RS18545 589264..589617 - 354 WP_069212062.1 IS66 family insertion sequence element accessory protein TnpB -
DYL72_RS18550 589614..589934 - 321 WP_081245520.1 IS66 family insertion sequence hypothetical protein -
DYL72_RS18555 590016..590905 + 890 Protein_508 IS256 family transposase -
DYL72_RS18560 590956..591255 - 300 WP_019282621.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DYL72_RS18565 591252..591494 - 243 WP_019282620.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
DYL72_RS18570 591589..592557 - 969 WP_081245536.1 IS30 family transposase -
DYL72_RS18580 592798..593313 + 516 WP_019283453.1 peptide deformylase -
DYL72_RS18595 595104..595817 + 714 WP_019283452.1 Fic family protein -
DYL72_RS18600 595814..595924 + 111 Protein_514 DUF3265 domain-containing protein -
DYL72_RS18605 595974..596351 + 378 WP_019283451.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 551258..597435 46177
- inside Integron - - 592798..625119 32321


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-78)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11662.38 Da        Isoelectric Point: 9.8917

>T116355 WP_019282621.1 NZ_CP034673:c591255-590956 [Vibrio anguillarum]
MKPFQLTNKAKSDLKDIALFTSRRWGREQRNIYLKQFDESFWLLAENPDIGKTCDEIRDGYRKFPQGSHVIFYQQIGSQN
IQIIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T116355 NZ_CP034673:c591255-590956 [Vibrio anguillarum]
ATGAAACCATTCCAACTAACCAACAAGGCAAAATCCGATTTAAAAGATATTGCCTTATTTACCTCTCGCAGGTGGGGCCG
CGAGCAACGAAATATTTATCTCAAACAATTCGATGAATCATTTTGGCTACTCGCTGAAAATCCTGATATCGGTAAAACTT
GTGATGAAATCAGAGATGGCTACCGAAAATTTCCACAAGGAAGCCATGTTATTTTTTATCAACAAATTGGTAGCCAAAAC
ATCCAGATCATAAGAATCTTGCATAAGAGTATGGATGTAAATCCAATCTTTGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8946.90 Da        Isoelectric Point: 4.3085

>AT116355 WP_019282620.1 NZ_CP034673:c591494-591252 [Vibrio anguillarum]
MAKNTSITLGDHFDGFISSQIQSGRYGSASEVIRSALRLLETQETKMNTLRQLLVEGEESGMADYDLNSFISELDSEERK

Download         Length: 243 bp

>AT116355 NZ_CP034673:c591494-591252 [Vibrio anguillarum]
ATGGCTAAAAATACTAGCATCACTCTCGGCGACCACTTTGATGGTTTCATTAGTAGCCAAATCCAAAGTGGACGCTATGG
CTCAGCAAGTGAAGTAATTCGTTCCGCTCTACGTTTACTCGAAACACAAGAAACGAAAATGAACACTTTACGACAACTGC
TCGTTGAAGGTGAAGAAAGTGGTATGGCTGATTATGACCTCAATTCGTTTATCAGTGAACTAGATAGTGAAGAAAGAAAA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7X8U0Q7

Antitoxin

Source ID Structure
AlphaFold DB A0A289GHF4

References