Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2124315..2124957 Replicon chromosome
Accession NZ_CP034670
Organism Eikenella corrodens strain KCOM 3110

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag ELB75_RS10705 Protein ID WP_126983886.1
Coordinates 2124315..2124713 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag ELB75_RS10710 Protein ID WP_126983887.1
Coordinates 2124718..2124957 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELB75_RS10675 2120232..2120723 + 492 Protein_2059 RHS domain-containing protein -
ELB75_RS10680 2121071..2121754 + 684 WP_126983883.1 hypothetical protein -
ELB75_RS10685 2121991..2123136 + 1146 WP_126983884.1 RHS domain-containing protein -
ELB75_RS10690 2123305..2123592 + 288 WP_126983885.1 hypothetical protein -
ELB75_RS10700 2123818..2124171 + 354 Protein_2063 RHS repeat family protein -
ELB75_RS10705 2124315..2124713 - 399 WP_126983886.1 type II toxin-antitoxin system VapC family toxin Toxin
ELB75_RS10710 2124718..2124957 - 240 WP_126983887.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
ELB75_RS10715 2125452..2125805 - 354 WP_126983888.1 hypothetical protein -
ELB75_RS10720 2126233..2128197 - 1965 WP_126983889.1 DUF927 domain-containing protein -
ELB75_RS10725 2128211..2129284 - 1074 WP_126983890.1 toprim domain-containing protein -
ELB75_RS10730 2129447..2129842 - 396 WP_126983891.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(7-43)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14443.59 Da        Isoelectric Point: 7.4188

>T116354 WP_126983886.1 NZ_CP034670:c2124713-2124315 [Eikenella corrodens]
MRRYMLDTNAVNHALKQHPAFMEKLTAQPMAAVCISAVTRAEIAYGLAKRPDAVKLHRAVSEFLKRIDTLPYTEQDAAYY
GQFKAAVEQQGRSLSALDMLIAAHAAGNGLILVSHDGAFGKIDNLAVEDWAT

Download         Length: 399 bp

>T116354 NZ_CP034670:c2124713-2124315 [Eikenella corrodens]
ATGCGCCGCTATATGTTGGATACAAACGCCGTGAACCATGCTTTGAAGCAACACCCGGCCTTTATGGAGAAACTGACTGC
CCAGCCGATGGCTGCCGTGTGTATTTCCGCCGTTACCCGCGCTGAAATCGCCTACGGCTTGGCTAAGCGTCCAGATGCCG
TAAAGCTGCATAGAGCGGTGTCCGAGTTTCTGAAGCGTATAGATACCCTGCCATATACGGAGCAGGATGCGGCGTATTAC
GGGCAATTCAAGGCCGCCGTGGAGCAACAGGGGCGAAGTTTGTCTGCTTTGGATATGCTGATAGCCGCCCATGCTGCCGG
CAACGGCTTAATACTGGTTAGTCATGATGGCGCATTTGGTAAAATTGACAATTTAGCCGTTGAAGATTGGGCTACCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8817.69 Da        Isoelectric Point: 4.5557

>AT116354 WP_126983887.1 NZ_CP034670:c2124957-2124718 [Eikenella corrodens]
MQTAKLFTNGRSQAVRLPAAFRFEGDTVYIRRDENGDVVLSAKPADWQGFNAAARELAGEGIERAQGSQERDVFADWQE

Download         Length: 240 bp

>AT116354 NZ_CP034670:c2124957-2124718 [Eikenella corrodens]
ATGCAGACCGCCAAATTGTTTACCAACGGTCGCAGTCAAGCCGTGCGCCTGCCTGCCGCCTTCCGTTTTGAAGGCGATAC
GGTGTATATCCGCCGAGATGAAAACGGCGATGTCGTTTTATCTGCCAAGCCTGCCGATTGGCAGGGGTTTAATGCCGCCG
CCCGAGAATTGGCGGGAGAAGGCATAGAACGCGCCCAAGGCAGCCAAGAGCGCGACGTTTTCGCAGATTGGCAGGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References