Detailed information of TA system TA116354

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2124315..2124957
• Replicon: chromosome
• Accession: NZ_CP034670
• Organism: Eikenella corrodens strain KCOM 3110

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: ELB75_RS10705
• Protein ID: WP_126983886.1
• Coordinates: 2124315..2124713 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: ELB75_RS10710
• Protein ID: WP_126983887.1
• Coordinates: 2124718..2124957 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ELB75_RS10675	2120232..2120723	+	492	Protein_2059	RHS domain-containing protein	-
ELB75_RS10680	2121071..2121754	+	684	WP_126983883.1	hypothetical protein	-
ELB75_RS10685	2121991..2123136	+	1146	WP_126983884.1	RHS domain-containing protein	-
ELB75_RS10690	2123305..2123592	+	288	WP_126983885.1	hypothetical protein	-
ELB75_RS10700	2123818..2124171	+	354	Protein_2063	RHS repeat family protein	-
ELB75_RS10705	2124315..2124713	-	399	WP_126983886.1	type II toxin-antitoxin system VapC family toxin	Toxin
ELB75_RS10710	2124718..2124957	-	240	WP_126983887.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
ELB75_RS10715	2125452..2125805	-	354	WP_126983888.1	hypothetical protein	-
ELB75_RS10720	2126233..2128197	-	1965	WP_126983889.1	DUF927 domain-containing protein	-
ELB75_RS10725	2128211..2129284	-	1074	WP_126983890.1	toprim domain-containing protein	-
ELB75_RS10730	2129447..2129842	-	396	WP_126983891.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-123)

Antitoxin

• SpoVT-AbrB domain (7-43)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14443.59 Da
• Isoelectric Point: 7.4188

>T116354 WP_126983886.1 NZ_CP034670:c2124713-2124315 [Eikenella corrodens]
MRRYMLDTNAVNHALKQHPAFMEKLTAQPMAAVCISAVTRAEIAYGLAKRPDAVKLHRAVSEFLKRIDTLPYTEQDAAYY
GQFKAAVEQQGRSLSALDMLIAAHAAGNGLILVSHDGAFGKIDNLAVEDWAT

Nucleotide

• Length: 399 bp

>T116354 NZ_CP034670:c2124713-2124315 [Eikenella corrodens]
ATGCGCCGCTATATGTTGGATACAAACGCCGTGAACCATGCTTTGAAGCAACACCCGGCCTTTATGGAGAAACTGACTGC
CCAGCCGATGGCTGCCGTGTGTATTTCCGCCGTTACCCGCGCTGAAATCGCCTACGGCTTGGCTAAGCGTCCAGATGCCG
TAAAGCTGCATAGAGCGGTGTCCGAGTTTCTGAAGCGTATAGATACCCTGCCATATACGGAGCAGGATGCGGCGTATTAC
GGGCAATTCAAGGCCGCCGTGGAGCAACAGGGGCGAAGTTTGTCTGCTTTGGATATGCTGATAGCCGCCCATGCTGCCGG
CAACGGCTTAATACTGGTTAGTCATGATGGCGCATTTGGTAAAATTGACAATTTAGCCGTTGAAGATTGGGCTACCTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8817.69 Da
• Isoelectric Point: 4.5557

>AT116354 WP_126983887.1 NZ_CP034670:c2124957-2124718 [Eikenella corrodens]
MQTAKLFTNGRSQAVRLPAAFRFEGDTVYIRRDENGDVVLSAKPADWQGFNAAARELAGEGIERAQGSQERDVFADWQE

Nucleotide

• Length: 240 bp

>AT116354 NZ_CP034670:c2124957-2124718 [Eikenella corrodens]
ATGCAGACCGCCAAATTGTTTACCAACGGTCGCAGTCAAGCCGTGCGCCTGCCTGCCGCCTTCCGTTTTGAAGGCGATAC
GGTGTATATCCGCCGAGATGAAAACGGCGATGTCGTTTTATCTGCCAAGCCTGCCGATTGGCAGGGGTTTAATGCCGCCG
CCCGAGAATTGGCGGGAGAAGGCATAGAACGCGCCCAAGGCAGCCAAGAGCGCGACGTTTTCGCAGATTGGCAGGAATAG