Detailed information of TA system TA116353

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 1340467..1341131
• Replicon: chromosome
• Accession: NZ_CP034670
• Organism: Eikenella corrodens strain KCOM 3110

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: ELB75_RS06735
• Protein ID: WP_126983266.1
• Coordinates: 1340467..1340895 (-)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: ELB75_RS06740
• Protein ID: WP_126983267.1
• Coordinates: 1340892..1341131 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ELB75_RS06710	1335531..1335770	-	240	WP_049258047.1	DNA-binding transcriptional regulator Fis	-
ELB75_RS06715	1335873..1336877	-	1005	WP_126983262.1	tRNA dihydrouridine synthase DusB	-
ELB75_RS06720	1337073..1337351	-	279	WP_126983263.1	hypothetical protein	-
ELB75_RS06725	1337363..1339852	-	2490	WP_126983264.1	TraC family protein	-
ELB75_RS06730	1339911..1340342	-	432	WP_126983265.1	single-stranded DNA-binding protein	-
ELB75_RS06735	1340467..1340895	-	429	WP_126983266.1	type II toxin-antitoxin system VapC family toxin	Toxin
ELB75_RS06740	1340892..1341131	-	240	WP_126983267.1	hypothetical protein	Antitoxin
ELB75_RS06745	1341269..1341853	-	585	WP_126983268.1	hypothetical protein	-
ELB75_RS06750	1341961..1342473	-	513	WP_126983269.1	hypothetical protein	-
ELB75_RS06755	1342488..1343582	-	1095	WP_164726833.1	DUF1845 family protein	-
ELB75_RS06760	1343786..1345477	-	1692	WP_206501440.1	hypothetical protein	-
ELB75_RS06765	1345449..1345946	-	498	WP_064089673.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-127)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 15235.50 Da
• Isoelectric Point: 5.1358

>T116353 WP_126983266.1 NZ_CP034670:c1340895-1340467 [Eikenella corrodens]
MILVDTNVISETLRQQPDPAVVRWMDAQSIETLYLSAVTVAELRYGIAVLPEGRKRQVLHNGLEQSVLPLFEGRILPFDG
AAAISYAELMAAARRRGRGVSAADGYIAATAHAAGLMVATRDTSPFEAVGLAVVNPWLFDAG

Nucleotide

• Length: 429 bp

>T116353 NZ_CP034670:c1340895-1340467 [Eikenella corrodens]
ATGATTTTAGTCGATACCAACGTCATTTCCGAGACTCTTCGGCAGCAGCCCGATCCTGCCGTTGTGCGCTGGATGGATGC
CCAGTCGATCGAAACGCTTTATCTGTCGGCCGTGACGGTGGCCGAACTGCGCTACGGCATTGCCGTACTGCCGGAAGGCA
GGAAGCGGCAAGTGCTGCATAACGGGCTGGAGCAGTCGGTACTACCCCTGTTCGAGGGGCGTATCCTGCCTTTTGATGGC
GCAGCAGCGATATCGTATGCCGAATTGATGGCTGCCGCCCGCCGTCGGGGCCGGGGGGTGTCGGCAGCCGACGGCTATAT
TGCCGCCACCGCCCATGCCGCCGGTTTGATGGTGGCAACCCGGGATACCTCTCCGTTCGAGGCGGTCGGTTTGGCGGTAG
TCAATCCCTGGCTGTTTGATGCCGGGTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8540.71 Da
• Isoelectric Point: 10.1954

>AT116353 WP_126983267.1 NZ_CP034670:c1341131-1340892 [Eikenella corrodens]
MAAITIRNLSDETHRALKARAASAGRSTEAEIRLILEQAARPERRIKLGSLLTGLGRQAGGVDLETVRDPSVTQPVSYE

Nucleotide

• Length: 240 bp

>AT116353 NZ_CP034670:c1341131-1340892 [Eikenella corrodens]
ATGGCTGCCATCACCATCCGCAACCTGTCCGACGAAACCCACCGCGCCCTGAAAGCCCGGGCGGCCTCCGCCGGGCGCAG
CACCGAGGCGGAAATCCGTCTGATTCTGGAGCAGGCCGCCCGTCCCGAGCGGCGGATTAAATTGGGCTCGCTGCTGACCG
GTTTGGGCCGGCAGGCCGGCGGGGTGGATTTGGAAACCGTCCGTGATCCTTCCGTCACACAGCCGGTGTCATACGAATGA