Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-MqsA
Location 3818636..3819335 Replicon chromosome
Accession NZ_CP034668
Organism Proteus vulgaris strain PvSC3

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag EKQ45_RS19860 Protein ID WP_075671320.1
Coordinates 3818636..3819022 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag EKQ45_RS19865 Protein ID WP_075671318.1
Coordinates 3819015..3819335 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EKQ45_RS19845 3814674..3815258 - 585 WP_109419307.1 DNA-3-methyladenine glycosylase I -
EKQ45_RS19850 3815497..3816402 + 906 WP_004246832.1 glycine--tRNA ligase subunit alpha -
EKQ45_RS19855 3816412..3818484 + 2073 WP_191901644.1 glycine--tRNA ligase subunit beta -
EKQ45_RS19860 3818636..3819022 + 387 WP_075671320.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EKQ45_RS19865 3819015..3819335 + 321 WP_075671318.1 helix-turn-helix domain-containing protein Antitoxin
EKQ45_RS19870 3819403..3819723 - 321 WP_191901645.1 hypothetical protein -
EKQ45_RS19875 3819829..3821115 - 1287 WP_159242125.1 DUF3748 domain-containing protein -
EKQ45_RS19880 3821252..3821869 + 618 WP_006534609.1 trimeric intracellular cation channel family protein -
EKQ45_RS19885 3822175..3822798 + 624 WP_006534608.1 guanylate kinase -
EKQ45_RS19890 3822853..3823128 + 276 WP_004246820.1 DNA-directed RNA polymerase subunit omega -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-125)

Antitoxin

Cro/C1-type helix-turn-helix domain

(50-96)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14358.75 Da        Isoelectric Point: 10.0463

>T116351 WP_075671320.1 NZ_CP034668:3818636-3819022 [Proteus vulgaris]
MVIYKTKMFKNSFKKMPINDAALIDIANEVYAGHFEADLGGGIIKKRICIHGKGKSSGIRTIIFYKQGSNLFFADGWKKS
HLSAKKSKEITDDELESYKDLAKDLFSATKNKIDKMVALGLLTEVKHD

Download         Length: 387 bp

>T116351 NZ_CP034668:3818636-3819022 [Proteus vulgaris]
ATGGTTATCTATAAAACAAAGATGTTCAAAAACAGTTTCAAGAAAATGCCTATCAATGATGCTGCTTTAATAGATATTGC
CAACGAAGTATATGCAGGACACTTTGAAGCTGACTTAGGTGGGGGGATTATCAAAAAACGGATCTGTATCCATGGAAAAG
GAAAGAGTAGTGGAATTAGAACAATTATATTTTATAAACAGGGAAGTAATTTATTCTTTGCTGATGGATGGAAAAAATCT
CACTTGAGCGCTAAAAAATCTAAAGAAATTACAGATGATGAACTAGAATCCTATAAAGATCTGGCAAAAGATCTCTTCAG
TGCAACTAAAAATAAAATAGATAAGATGGTTGCACTAGGCCTTTTAACGGAGGTTAAACATGACTGA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12068.99 Da        Isoelectric Point: 10.0482

>AT116351 WP_075671318.1 NZ_CP034668:3819015-3819335 [Proteus vulgaris]
MTDKMQEMLKFAQEMEVAGITDGESARRIAARIKAKELKERYAHLTPMNGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLNLIDNKAISI

Download         Length: 321 bp

>AT116351 NZ_CP034668:3819015-3819335 [Proteus vulgaris]
ATGACTGATAAAATGCAAGAAATGCTGAAATTTGCACAAGAAATGGAAGTTGCGGGAATAACCGATGGAGAATCGGCTAG
ACGAATTGCAGCGAGAATAAAAGCCAAAGAATTAAAAGAAAGATATGCTCACCTGACTCCAATGAATGGTGAAGATATAA
AAAGAATTCGCGAGCAAAATAATATTTCGCAATCGTCTCTTGCTTTAATACTAAATATGACAAAAGAGAGCGTATCAAAA
TGGGAGCGGAACGAAATTAAACCCAATGGAGCTGCATTGAGACTTTTGAATTTAATAGATAATAAAGCAATTTCAATCTA
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References