Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1016726..1017348 Replicon chromosome
Accession NZ_CP034665
Organism Moraxella catarrhalis strain 142P87B1

Toxin (Protein)


Gene name hicA Uniprot ID A0A1E9VU27
Locus tag EJK50_RS04640 Protein ID WP_003660025.1
Coordinates 1017166..1017348 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1E9VTZ2
Locus tag EJK50_RS04635 Protein ID WP_003660026.1
Coordinates 1016726..1017133 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJK50_RS04610 1013794..1014126 + 333 WP_117906198.1 phage tail protein -
EJK50_RS04615 1014230..1014619 + 390 WP_117906084.1 hypothetical protein -
EJK50_RS04620 1014703..1015371 + 669 WP_003665945.1 phage minor tail protein L -
EJK50_RS04625 1015368..1015571 - 204 WP_003665947.1 hypothetical protein -
EJK50_RS04630 1015955..1016734 + 780 WP_070473019.1 C40 family peptidase -
EJK50_RS04635 1016726..1017133 - 408 WP_003660026.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EJK50_RS04640 1017166..1017348 - 183 WP_003660025.1 type II toxin-antitoxin system HicA family toxin Toxin
EJK50_RS04645 1017448..1017771 + 324 Protein_898 tail assembly protein -
EJK50_RS04650 1017774..1018001 + 228 WP_003659817.1 hypothetical protein -
EJK50_RS08960 1018232..1018390 - 159 WP_003658126.1 hypothetical protein -
EJK50_RS04655 1018415..1019515 - 1101 WP_003673860.1 ABC transporter permease -
EJK50_RS04660 1019515..1020693 - 1179 WP_117906082.1 ABC transporter permease -
EJK50_RS04665 1020721..1021884 - 1164 WP_117906081.1 biotin/lipoyl-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 997289..1017774 20485


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-130)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6813.95 Da        Isoelectric Point: 10.6682

>T116346 WP_003660025.1 NZ_CP034665:c1017348-1017166 [Moraxella catarrhalis]
MNSRQMIKLITDDGWYEVAVRGSHHHYKHPTKQGKVTIPHPKSDLPIGTVKQILKQAGLK

Download         Length: 183 bp

>T116346 NZ_CP034665:c1017348-1017166 [Moraxella catarrhalis]
ATGAATAGCCGTCAAATGATTAAGCTAATCACTGATGACGGTTGGTATGAAGTTGCGGTGCGTGGCAGTCATCATCACTA
CAAACACCCAACCAAACAGGGCAAGGTAACCATACCTCACCCCAAGTCAGACTTACCAATCGGCACAGTTAAGCAAATCT
TAAAACAAGCTGGGTTAAAATAA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14907.99 Da        Isoelectric Point: 4.4954

>AT116346 WP_003660026.1 NZ_CP034665:c1017133-1016726 [Moraxella catarrhalis]
MLYPIAIEKPVSTNECYGVIVPDIVGCFSAGDTVDEAVKNAYEAIVLHLDMLADDGEDIPQATDIAHHQENPDYQGMIWA
VVDIDLSAYMGKSEKINVTLPSRLIVKIDEKVKAHKSLYKSRSNYLAQLASRDLA

Download         Length: 408 bp

>AT116346 NZ_CP034665:c1017133-1016726 [Moraxella catarrhalis]
ATGTTATATCCTATCGCCATTGAAAAGCCCGTCAGCACCAATGAGTGTTATGGCGTGATTGTACCTGATATTGTAGGCTG
TTTTAGTGCAGGCGATACAGTAGATGAGGCGGTTAAAAATGCCTATGAAGCCATTGTTTTGCATTTGGATATGTTGGCTG
ATGATGGTGAGGATATCCCTCAAGCGACCGATATTGCTCATCATCAAGAAAATCCTGATTATCAAGGTATGATTTGGGCG
GTGGTTGATATTGATTTATCCGCCTATATGGGCAAATCTGAAAAGATTAATGTTACCTTGCCAAGTCGCTTGATTGTCAA
AATTGACGAAAAGGTTAAAGCACACAAATCGCTATATAAGAGTCGTAGTAATTACCTAGCACAGCTTGCCAGTCGTGATT
TAGCCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E9VU27

Antitoxin

Source ID Structure
AlphaFold DB A0A1E9VTZ2

References