Detailed information of TA system TA116345

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 4420150..4420698
• Replicon: chromosome
• Accession: NZ_CP034660
• Organism: Colwellia sp. Arc7-635

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: EKO29_RS18960
• Protein ID: WP_126670330.1
• Coordinates: 4420150..4420443 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: EKO29_RS18965
• Protein ID: WP_126670331.1
• Coordinates: 4420447..4420698 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EKO29_RS18940	4415270..4416532	-	1263	WP_126669004.1	transposase	-
EKO29_RS18945	4417225..4418379	-	1155	WP_126667425.1	IS110 family transposase	-
EKO29_RS18950	4418629..4419255	+	627	WP_126670328.1	DUF4760 domain-containing protein	-
EKO29_RS18955	4419790..4420068	+	279	WP_126670329.1	hypothetical protein	-
EKO29_RS18960	4420150..4420443	-	294	WP_126670330.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EKO29_RS18965	4420447..4420698	-	252	WP_126670331.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
EKO29_RS18970	4421177..4421614	-	438	WP_126670851.1	GNAT family N-acetyltransferase	-
EKO29_RS18975	4421680..4422624	-	945	WP_126670332.1	DUF523 and DUF1722 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	4417225..4418379	1154

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-92)

Antitoxin

• Antitoxin ParD (1-78)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11283.05 Da
• Isoelectric Point: 8.7768

>T116345 WP_126670330.1 NZ_CP034660:c4420443-4420150 [Colwellia sp. Arc7-635]
MNKFVLSSEAKTDLIKIAKYTQITWGVSQRNDYLKVLDTTFKLLASEPELGMNCDYIREGYSKYPQASHVIYYKEHKDNQ
ILIVRILHKSMDVNPAL

Nucleotide

• Length: 294 bp

>T116345 NZ_CP034660:c4420443-4420150 [Colwellia sp. Arc7-635]
ATGAATAAGTTTGTATTATCTTCTGAAGCCAAAACAGACTTAATTAAAATAGCTAAATATACCCAAATAACTTGGGGAGT
ATCTCAGCGAAACGACTACCTAAAGGTATTAGATACTACATTTAAGTTGTTAGCCTCTGAACCCGAGTTAGGTATGAATT
GCGATTACATTAGAGAAGGTTACAGCAAATACCCACAAGCTAGTCATGTGATTTATTACAAAGAGCACAAAGACAATCAA
ATCCTTATAGTGCGTATATTACATAAAAGTATGGATGTTAACCCCGCACTCTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9290.23 Da
• Isoelectric Point: 4.5515

>AT116345 WP_126670331.1 NZ_CP034660:c4420698-4420447 [Colwellia sp. Arc7-635]
MAKNTSVTLGDHFDQFINQQLSTGRYGSASEIIRAGLRALEDQEAKLLNLRNMLIQGEQSGVAEYSYESLLTELDKDNHD
RSS

Nucleotide

• Length: 252 bp

>AT116345 NZ_CP034660:c4420698-4420447 [Colwellia sp. Arc7-635]
ATGGCTAAAAACACAAGCGTAACACTAGGCGATCATTTTGATCAGTTTATAAACCAACAACTTAGCACTGGTCGCTATGG
CTCAGCAAGTGAAATTATTAGAGCTGGATTAAGAGCCTTGGAAGATCAAGAAGCTAAGCTTTTAAATTTACGTAATATGT
TAATCCAAGGCGAACAGAGTGGCGTTGCCGAATACAGCTATGAAAGCTTATTGACTGAATTAGATAAAGATAACCATGAT
AGGTCTAGTTAA