Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 1613253..1613779 | Replicon | chromosome |
| Accession | NZ_CP034658 | ||
| Organism | Escherichia coli strain ATCC 98082 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | EKH78_RS07840 | Protein ID | WP_000323025.1 |
| Coordinates | 1613253..1613540 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | EKH78_RS07845 | Protein ID | WP_000534858.1 |
| Coordinates | 1613540..1613779 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EKH78_RS07795 (1608277) | 1608277..1608492 | - | 216 | WP_000839590.1 | phage lysis protein EssD | - |
| EKH78_RS24625 (1608712) | 1608712..1608882 | + | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| EKH78_RS07800 (1609246) | 1609246..1609461 | - | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| EKH78_RS07805 (1609762) | 1609762..1609974 | + | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| EKH78_RS07810 (1610029) | 1610029..1610118 | + | 90 | WP_120795389.1 | hypothetical protein | - |
| EKH78_RS07815 (1610396) | 1610396..1611148 | - | 753 | WP_001047135.1 | antitermination protein | - |
| EKH78_RS07820 (1611162) | 1611162..1612211 | - | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| EKH78_RS07825 (1612213) | 1612213..1612491 | - | 279 | WP_012304870.1 | hypothetical protein | - |
| EKH78_RS07830 (1612558) | 1612558..1612809 | - | 252 | WP_000980994.1 | protein Rem | - |
| EKH78_RS07835 (1613026) | 1613026..1613181 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| EKH78_RS07840 (1613253) | 1613253..1613540 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| EKH78_RS07845 (1613540) | 1613540..1613779 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| EKH78_RS07850 (1613804) | 1613804..1614109 | + | 306 | WP_001326990.1 | protein YdfV | - |
| EKH78_RS07855 (1614312) | 1614312..1614644 | + | 333 | WP_001301033.1 | FlxA-like family protein | - |
| EKH78_RS07860 (1615081) | 1615081..1615230 | - | 150 | WP_011443592.1 | protein YdfW | - |
| EKH78_RS07865 (1615265) | 1615265..1615543 | - | 279 | Protein_1559 | protein YdfX | - |
| EKH78_RS07870 (1615527) | 1615527..1615757 | - | 231 | WP_000920568.1 | dicB transcriptional regulator DicC | - |
| EKH78_RS07875 (1615841) | 1615841..1616248 | + | 408 | WP_000448564.1 | DNA-binding transcriptional dual regulator DicA | - |
| EKH78_RS07880 (1616415) | 1616415..1616570 | + | 156 | WP_000379575.1 | DUF1391 family protein | - |
| EKH78_RS24910 (1616572) | 1616572..1616700 | + | 129 | WP_000344964.1 | protein YdfB | - |
| EKH78_RS07885 (1616730) | 1616730..1616948 | + | 219 | WP_001171942.1 | protein YdfC | - |
| EKH78_RS07890 (1617516) | 1617516..1617704 | + | 189 | WP_000854559.1 | cell division inhibition protein DicB | - |
| EKH78_RS07895 (1617701) | 1617701..1617892 | + | 192 | WP_001083297.1 | lysis protein YdfD | - |
| EKH78_RS07900 (1617985) | 1617985..1618752 | + | 768 | Protein_1567 | exonuclease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1586560..1620615 | 34055 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T116314 WP_000323025.1 NZ_CP034658:c1613540-1613253 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T116314 NZ_CP034658:c1613540-1613253 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT116314 WP_000534858.1 NZ_CP034658:c1613779-1613540 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT116314 NZ_CP034658:c1613779-1613540 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|