Detailed information of TA system TA116294

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 2487490..2488164
• Replicon: chromosome
• Accession: NZ_CP034655
• Organism: Xanthomonas campestris pv. musacearum NCPPB 4379

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A837APC7
• Locus tag: KWO_RS11600
• Protein ID: WP_010373126.1
• Coordinates: 2487490..2487909 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A837APP1
• Locus tag: KWO_RS11605
• Protein ID: WP_010373123.1
• Coordinates: 2487910..2488164 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KWO_RS11560	2482605..2482805	-	201	WP_010378957.1	helix-turn-helix domain-containing protein	-
KWO_RS11565	2483135..2483503	+	369	WP_010378959.1	XRE family transcriptional regulator	-
KWO_RS11570	2483500..2483859	+	360	WP_010378961.1	hypothetical protein	-
KWO_RS11575	2484105..2484335	-	231	WP_010378963.1	type I toxin-antitoxin system ptaRNA1 family toxin	-
KWO_RS11580	2484398..2484676	-	279	WP_017113202.1	hypothetical protein	-
KWO_RS11585	2484673..2486253	-	1581	WP_017113203.1	P-type conjugative transfer protein TrbL	-
KWO_RS11590	2486250..2486519	-	270	WP_017113204.1	entry exclusion lipoprotein TrbK	-
KWO_RS11595	2486535..2487320	-	786	Protein_2123	P-type conjugative transfer protein TrbJ	-
KWO_RS11600	2487490..2487909	-	420	WP_010373126.1	type II toxin-antitoxin system VapC family toxin	Toxin
KWO_RS11605	2487910..2488164	-	255	WP_010373123.1	plasmid stabilization protein	Antitoxin
KWO_RS11610	2488232..2490040	-	1809	WP_017113207.1	relaxase/mobilization nuclease domain-containing protein	-
KWO_RS11615	2490075..2490446	-	372	WP_010378981.1	conjugal transfer transcriptional regulator TraJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2482605..2495167	12562

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-128)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 15049.13 Da
• Isoelectric Point: 4.5762

>T116294 WP_010373126.1 NZ_CP034655:c2487909-2487490 [Xanthomonas campestris pv. musacearum NCPPB 4379]
MIVLDTNVVSEAMKPEPDAAVRAWLNDQAAETLYLSSVTLAELLFGIRALPAGKRKNMLDRALTELLELFKDRVLPFDTD
AARHYADLAVTAKNGGRGFPTPDGYIAAVAASRGFIVASRDTSPYEAAGVNVINPWEDV

Nucleotide

• Length: 420 bp

>T116294 NZ_CP034655:c2487909-2487490 [Xanthomonas campestris pv. musacearum NCPPB 4379]
ATGATCGTCCTGGATACCAACGTCGTTTCAGAGGCGATGAAGCCGGAGCCGGACGCGGCCGTGAGGGCCTGGCTGAACGA
CCAAGCGGCGGAAACCTTGTACCTGTCCAGCGTCACGCTGGCCGAGTTGCTGTTTGGCATCCGGGCGCTGCCGGCGGGCA
AGCGCAAGAACATGCTCGACCGCGCTCTGACCGAGCTGCTGGAACTGTTCAAGGATCGGGTCTTGCCGTTCGATACGGAT
GCAGCGCGCCACTATGCCGACCTGGCCGTGACGGCCAAGAACGGCGGGCGCGGCTTCCCGACGCCAGACGGCTACATCGC
GGCCGTTGCAGCCTCGCGGGGCTTCATCGTGGCATCGCGCGACACATCGCCCTATGAAGCGGCTGGCGTGAATGTCATCA
ACCCTTGGGAGGATGTATAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9274.71 Da
• Isoelectric Point: 10.5807

>AT116294 WP_010373123.1 NZ_CP034655:c2488164-2487910 [Xanthomonas campestris pv. musacearum NCPPB 4379]
MAILTVRNVPDDVHRALRVRAAQHGRSTEAEVREILAAVVKPEKRVRVGEALAAIGRKIGLTNEDFAVFESVRDKTPAKP
LSFE

Nucleotide

• Length: 255 bp

>AT116294 NZ_CP034655:c2488164-2487910 [Xanthomonas campestris pv. musacearum NCPPB 4379]
ATGGCAATTCTGACTGTAAGGAATGTGCCGGATGACGTGCATCGCGCTTTGCGCGTGCGGGCGGCCCAACATGGCCGCAG
TACGGAAGCGGAGGTGCGCGAGATTCTGGCGGCCGTGGTCAAGCCGGAGAAGCGCGTGCGTGTGGGTGAAGCCCTAGCCG
CCATCGGCCGCAAGATCGGGCTGACCAATGAGGATTTCGCCGTGTTCGAGAGCGTGCGCGACAAGACGCCGGCCAAACCG
TTGAGCTTCGAGTGA

Structures

Toxin

• AlphaFold DB: A0A837APC7

Antitoxin

• AlphaFold DB: A0A837APP1