Detailed information of TA system TA116293

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 2226..2779
• Replicon: plasmid pXCARECAE29
• Accession: NZ_CP034654
• Organism: Xanthomonas vasicola pv. arecae strain NCPPB 2649

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: NX80_RS22850
• Protein ID: WP_047698012.1
• Coordinates: 2486..2779 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A6M2VW75
• Locus tag: NX80_RS22845
• Protein ID: WP_005933973.1
• Coordinates: 2226..2498 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NX80_RS22835	167..475	+	309	WP_005933969.1	hypothetical protein	-
NX80_RS22840	472..2148	+	1677	WP_082337838.1	relaxase/mobilization nuclease domain-containing protein	-
NX80_RS22845	2226..2498	+	273	WP_005933973.1	CopG family ribbon-helix-helix protein	Antitoxin
NX80_RS22850	2486..2779	+	294	WP_047698012.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
NX80_RS22855	2779..3057	+	279	WP_047698011.1	hypothetical protein	-
NX80_RS22860	3191..3382	+	192	WP_126925421.1	hypothetical protein	-
NX80_RS22865	3372..3686	+	315	WP_047698009.1	hypothetical protein	-
NX80_RS22870	3736..4257	-	522	WP_047698008.1	hypothetical protein	-
NX80_RS22875	4267..6438	-	2172	WP_047698007.1	DotA/TraY family protein	-
NX80_RS22880	6435..6779	-	345	WP_047698006.1	hypothetical protein	-
NX80_RS22885	7006..7284	-	279	WP_126925417.1	hypothetical protein	-
NX80_RS22890	7345..7527	+	183	WP_126925418.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..29215	29215

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-95)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-40)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11022.46 Da
• Isoelectric Point: 6.2258

>T116293 WP_047698012.1 NZ_CP034654:2486-2779 [Xanthomonas vasicola pv. arecae]
VPHVIITEGAGQGLERCRRFLANKSPEAARRAAQAIERQFLLLETTPTIGRPFPEQPEWRELVIEFGDSGYVALYRHEPA
DDAVYVLAFRHQKEAGY

Nucleotide

• Length: 294 bp

>T116293 NZ_CP034654:2486-2779 [Xanthomonas vasicola pv. arecae]
GTGCCACACGTAATCATCACCGAAGGCGCGGGCCAAGGGTTGGAGCGCTGTCGGCGCTTTCTGGCCAACAAGAGCCCAGA
GGCAGCCCGACGGGCCGCCCAAGCCATCGAGCGACAGTTCTTGCTGCTAGAAACGACCCCGACCATAGGTCGCCCTTTTC
CTGAGCAACCGGAGTGGCGCGAGCTGGTCATTGAATTCGGTGATTCCGGCTATGTGGCCTTGTACCGCCACGAGCCTGCA
GATGATGCCGTCTACGTGCTGGCCTTCCGGCACCAGAAGGAAGCGGGGTACTGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10484.62 Da
• Isoelectric Point: 6.0804

>AT116293 WP_005933973.1 NZ_CP034654:2226-2498 [Xanthomonas vasicola pv. arecae]
MATSLKIDDELKGRVQHLASLRDRSPHWIMREAIKQYVEREEARESFKQEAQASWTAYQETGRHLTGQEVRAWLSTWGTD
NETGLPECHT

Nucleotide

• Length: 273 bp

>AT116293 NZ_CP034654:2226-2498 [Xanthomonas vasicola pv. arecae]
ATGGCAACGTCACTCAAAATCGACGACGAGCTGAAAGGGCGCGTGCAGCACCTGGCCAGCCTGCGCGATCGGTCGCCACA
CTGGATCATGCGTGAGGCGATCAAGCAGTACGTCGAGCGTGAGGAAGCGCGCGAAAGCTTCAAGCAGGAGGCGCAGGCGT
CCTGGACGGCCTATCAGGAAACCGGCCGGCATTTGACCGGGCAAGAAGTGCGCGCGTGGTTGAGCACTTGGGGCACAGAT
AACGAAACGGGACTGCCTGAGTGCCACACGTAA

Structures

Antitoxin

• AlphaFold DB: A0A6M2VW75