Detailed information of TA system TA116291

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PemK-MazE
• Location: 2676297..2676838
• Replicon: chromosome
• Accession: NZ_CP034653
• Organism: Xanthomonas vasicola pv. arecae strain NCPPB 2649

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: A0A220WPB1
• Locus tag: NX80_RS12330
• Protein ID: WP_005917856.1
• Coordinates: 2676515..2676838 (+)
• Length: 108 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: A0A220WPJ3
• Locus tag: NX80_RS12325
• Protein ID: WP_005917854.1
• Coordinates: 2676297..2676518 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NX80_RS12285	2671482..2671841	+	360	WP_175021602.1	hypothetical protein	-
NX80_RS12290	2671945..2672304	+	360	WP_033483239.1	hypothetical protein	-
NX80_RS12300	2672564..2673364	-	801	WP_126925216.1	IS21-like element helper ATPase IstB	-
NX80_RS12305	2673364..2674404	-	1041	WP_033011908.1	IS21 family transposase	-
NX80_RS12310	2674484..2675371	-	888	Protein_2274	ParA family protein	-
NX80_RS12315	2675526..2676098	-	573	WP_003490825.1	recombinase family protein	-
NX80_RS12325	2676297..2676518	+	222	WP_005917854.1	antitoxin MazE family protein	Antitoxin
NX80_RS12330	2676515..2676838	+	324	WP_005917856.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
NX80_RS12335	2676864..2677151	+	288	WP_029220894.1	hypothetical protein	-
NX80_RS12340	2677158..2678345	+	1188	WP_003490828.1	zeta toxin family protein	-
NX80_RS12345	2678531..2678815	-	285	WP_003490829.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2630254..2740822	110568

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-103)

Antitoxin

• Antitoxin MazE-like (9-72)

Sequences

Toxin

Protein

• Length: 108 a.a.
• Molecular weight: 11513.56 Da
• Isoelectric Point: 6.2913

>T116291 WP_005917856.1 NZ_CP034653:2676515-2676838 [Xanthomonas vasicola pv. arecae]
MTQRGDLVTVALPGAYGKPRPALVIQSDLLAELESVLVCPITSDLRDAMFRVTVEPSLTNGLQKISQVMVDKTAPIPRAK
VSEPIGTLDAERMRAVERALMLVTGLA

Nucleotide

• Length: 324 bp

>T116291 NZ_CP034653:2676515-2676838 [Xanthomonas vasicola pv. arecae]
ATGACGCAGCGTGGCGACTTGGTAACGGTGGCTTTGCCGGGAGCCTACGGCAAGCCACGGCCGGCGCTAGTCATCCAGTC
CGATTTGCTTGCCGAGCTGGAAAGCGTCCTCGTATGCCCGATCACAAGCGATCTGCGCGACGCGATGTTTCGGGTCACGG
TCGAGCCGAGTCTGACCAATGGTCTACAGAAGATTTCGCAGGTCATGGTGGACAAGACAGCACCGATACCTCGCGCGAAA
GTCAGTGAGCCGATTGGCACGCTCGACGCAGAACGCATGAGGGCCGTCGAACGCGCCCTCATGCTCGTCACCGGGCTGGC
ATAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8240.23 Da
• Isoelectric Point: 8.1023

>AT116291 WP_005917854.1 NZ_CP034653:2676297-2676518 [Xanthomonas vasicola pv. arecae]
MPRTHNPTNKVTRHRDRLRAAGYRPVQFWVHDTRSPELAAMLSRQCRSLHGDPTETDAIGFGEAAAGLIEGWE

Nucleotide

• Length: 222 bp

>AT116291 NZ_CP034653:2676297-2676518 [Xanthomonas vasicola pv. arecae]
ATGCCGAGAACTCACAATCCGACGAACAAGGTCACCCGTCATCGTGACCGACTGCGTGCAGCCGGGTACAGGCCAGTGCA
GTTTTGGGTGCACGATACCCGCTCGCCCGAGTTGGCTGCGATGCTCAGCCGCCAGTGTCGCAGCCTGCATGGTGATCCAA
CCGAAACCGATGCTATCGGCTTCGGTGAAGCCGCCGCTGGCCTTATCGAGGGGTGGGAATGA

Structures

Toxin

• AlphaFold DB: A0A220WPB1

Antitoxin

• AlphaFold DB: A0A220WPJ3