Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 2676297..2676838 Replicon chromosome
Accession NZ_CP034653
Organism Xanthomonas vasicola pv. arecae strain NCPPB 2649

Toxin (Protein)


Gene name mazF Uniprot ID A0A220WPB1
Locus tag NX80_RS12330 Protein ID WP_005917856.1
Coordinates 2676515..2676838 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A220WPJ3
Locus tag NX80_RS12325 Protein ID WP_005917854.1
Coordinates 2676297..2676518 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NX80_RS12285 2671482..2671841 + 360 WP_175021602.1 hypothetical protein -
NX80_RS12290 2671945..2672304 + 360 WP_033483239.1 hypothetical protein -
NX80_RS12300 2672564..2673364 - 801 WP_126925216.1 IS21-like element helper ATPase IstB -
NX80_RS12305 2673364..2674404 - 1041 WP_033011908.1 IS21 family transposase -
NX80_RS12310 2674484..2675371 - 888 Protein_2274 ParA family protein -
NX80_RS12315 2675526..2676098 - 573 WP_003490825.1 recombinase family protein -
NX80_RS12325 2676297..2676518 + 222 WP_005917854.1 antitoxin MazE family protein Antitoxin
NX80_RS12330 2676515..2676838 + 324 WP_005917856.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NX80_RS12335 2676864..2677151 + 288 WP_029220894.1 hypothetical protein -
NX80_RS12340 2677158..2678345 + 1188 WP_003490828.1 zeta toxin family protein -
NX80_RS12345 2678531..2678815 - 285 WP_003490829.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2630254..2740822 110568


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-103)

Antitoxin

Antitoxin MazE-like

(9-72)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 11513.56 Da        Isoelectric Point: 6.2913

>T116291 WP_005917856.1 NZ_CP034653:2676515-2676838 [Xanthomonas vasicola pv. arecae]
MTQRGDLVTVALPGAYGKPRPALVIQSDLLAELESVLVCPITSDLRDAMFRVTVEPSLTNGLQKISQVMVDKTAPIPRAK
VSEPIGTLDAERMRAVERALMLVTGLA

Download         Length: 324 bp

>T116291 NZ_CP034653:2676515-2676838 [Xanthomonas vasicola pv. arecae]
ATGACGCAGCGTGGCGACTTGGTAACGGTGGCTTTGCCGGGAGCCTACGGCAAGCCACGGCCGGCGCTAGTCATCCAGTC
CGATTTGCTTGCCGAGCTGGAAAGCGTCCTCGTATGCCCGATCACAAGCGATCTGCGCGACGCGATGTTTCGGGTCACGG
TCGAGCCGAGTCTGACCAATGGTCTACAGAAGATTTCGCAGGTCATGGTGGACAAGACAGCACCGATACCTCGCGCGAAA
GTCAGTGAGCCGATTGGCACGCTCGACGCAGAACGCATGAGGGCCGTCGAACGCGCCCTCATGCTCGTCACCGGGCTGGC
ATAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8240.23 Da        Isoelectric Point: 8.1023

>AT116291 WP_005917854.1 NZ_CP034653:2676297-2676518 [Xanthomonas vasicola pv. arecae]
MPRTHNPTNKVTRHRDRLRAAGYRPVQFWVHDTRSPELAAMLSRQCRSLHGDPTETDAIGFGEAAAGLIEGWE

Download         Length: 222 bp

>AT116291 NZ_CP034653:2676297-2676518 [Xanthomonas vasicola pv. arecae]
ATGCCGAGAACTCACAATCCGACGAACAAGGTCACCCGTCATCGTGACCGACTGCGTGCAGCCGGGTACAGGCCAGTGCA
GTTTTGGGTGCACGATACCCGCTCGCCCGAGTTGGCTGCGATGCTCAGCCGCCAGTGTCGCAGCCTGCATGGTGATCCAA
CCGAAACCGATGCTATCGGCTTCGGTGAAGCCGCCGCTGGCCTTATCGAGGGGTGGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A220WPB1

Antitoxin

Source ID Structure
AlphaFold DB A0A220WPJ3

References