Detailed information of TA system TA116283

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 3890799..3891613
• Replicon: chromosome
• Accession: NZ_CP034595
• Organism: Escherichia coli strain WCHEC035053S1G0

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: DK245_RS19155
• Protein ID: WP_001054376.1
• Coordinates: 3890799..3891056 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: U9Z4B8
• Locus tag: DK245_RS19160
• Protein ID: WP_001309181.1
• Coordinates: 3891068..3891613 (+)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DK245_RS19135	3886087..3887193	+	1107	WP_001309184.1	N-acetylneuraminate epimerase	-
DK245_RS19140	3887258..3888238	+	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
DK245_RS19145	3888821..3890061	-	1241	Protein_3720	helicase YjhR	-
DK245_RS19150	3890177..3890422	+	246	Protein_3721	GNAT family N-acetyltransferase	-
DK245_RS19155	3890799..3891056	+	258	WP_001054376.1	hypothetical protein	Toxin
DK245_RS19160	3891068..3891613	+	546	WP_001309181.1	N-acetyltransferase	Antitoxin
DK245_RS19165	3891669..3892415	+	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
DK245_RS19170	3892584..3892802	+	219	Protein_3725	hypothetical protein	-
DK245_RS22990	3892840..3892956	+	117	Protein_3726	VOC family protein	-
DK245_RS19175	3893201..3894322	+	1122	WP_000010829.1	M42 family metallopeptidase	-
DK245_RS19180	3894319..3894597	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
DK245_RS19185	3894609..3895922	+	1314	WP_000460843.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimB	3883293..3899837	16544

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T116283 WP_001054376.1 NZ_CP034595:3890799-3891056 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T116283 NZ_CP034595:3890799-3891056 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19956.90 Da
• Isoelectric Point: 6.3277

>AT116283 WP_001309181.1 NZ_CP034595:3891068-3891613 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT116283 NZ_CP034595:3891068-3891613 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: U9Z4B8