Detailed information of TA system TA116257

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 2591969..2592501
• Replicon: chromosome
• Accession: NZ_CP034593
• Organism: Flaviflexus sp. H23T48

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: EJ997_RS11615
• Protein ID: WP_126704688.1
• Coordinates: 2592199..2592501 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: EJ997_RS11610
• Protein ID: WP_126704687.1
• Coordinates: 2591969..2592202 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EJ997_RS11580	2587734..2588135	+	402	WP_126704683.1	hypothetical protein	-
EJ997_RS11585	2588404..2588823	+	420	WP_126704684.1	hypothetical protein	-
EJ997_RS11590	2589056..2589460	+	405	WP_126704685.1	hypothetical protein	-
EJ997_RS11595	2589539..2589829	-	291	Protein_2303	transposase	-
EJ997_RS11600	2590031..2591362	-	1332	WP_206501663.1	DUF2254 domain-containing protein	-
EJ997_RS13005	2591378..2591779	-	402	WP_164719993.1	alcohol dehydrogenase catalytic domain-containing protein	-
EJ997_RS11610	2591969..2592202	+	234	WP_126704687.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
EJ997_RS11615	2592199..2592501	+	303	WP_126704688.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EJ997_RS11620	2592849..2594048	+	1200	WP_206501664.1	DUF4143 domain-containing protein	-
EJ997_RS11625	2594231..2595028	+	798	WP_126704689.1	HAMP domain-containing histidine kinase	-
EJ997_RS11630	2595067..2595711	+	645	WP_206501924.1	response regulator	-
EJ997_RS11635	2595864..2597279	+	1416	WP_126704691.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2589539..2589772	233

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-91)

Antitoxin

• Antitoxin ParD (4-72)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11779.52 Da
• Isoelectric Point: 9.3864

>T116257 WP_126704688.1 NZ_CP034593:2592199-2592501 [Flaviflexus sp. H23T48]
VKPYLLVPAAQRDLSAIWDYTLEVWGAAQAELYIDDLRDGIKKIAADPSRGRRCDDIREGYRRYPVRSHIVFYRERSDAV
IVVRVLHKRMDVWQHVRAVE

Nucleotide

• Length: 303 bp

>T116257 NZ_CP034593:2592199-2592501 [Flaviflexus sp. H23T48]
GTGAAACCTTATCTCCTTGTTCCCGCTGCACAACGGGATCTCTCTGCGATCTGGGACTACACGCTTGAGGTGTGGGGCGC
GGCTCAAGCCGAGCTATATATAGATGACTTGCGGGATGGGATTAAGAAAATTGCGGCAGACCCGTCCCGAGGGCGCCGAT
GCGACGACATTCGAGAAGGATACCGTCGTTATCCGGTGCGGAGTCATATTGTTTTCTACCGGGAGCGAAGCGACGCCGTT
ATCGTGGTTAGAGTGCTGCACAAACGAATGGATGTATGGCAACACGTAAGGGCTGTGGAATGA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8480.39 Da
• Isoelectric Point: 4.2690

>AT116257 WP_126704687.1 NZ_CP034593:2591969-2592202 [Flaviflexus sp. H23T48]
MARNTSISLDDHFADFLAKEVASGRYGSVSEVVRAGLRLLEDQELHLAALRSALVEGEESGAPEEFDFDEFLAARRP

Nucleotide

• Length: 234 bp

>AT116257 NZ_CP034593:2591969-2592202 [Flaviflexus sp. H23T48]
ATGGCTCGTAATACATCGATCAGTCTTGATGATCATTTTGCTGACTTTCTTGCGAAGGAAGTCGCCTCCGGTCGTTACGG
ATCCGTGAGTGAGGTTGTCCGAGCAGGCCTTCGTCTGCTCGAGGATCAAGAGCTTCATTTGGCGGCCCTGCGATCAGCTC
TTGTTGAAGGAGAGGAAAGTGGCGCGCCGGAGGAGTTTGATTTCGATGAATTTCTTGCAGCAAGGCGGCCGTGA