Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 1880192..1880739 Replicon chromosome
Accession NZ_CP034565
Organism Vibrio parahaemolyticus strain D3112

Toxin (Protein)


Gene name relE Uniprot ID A0A347UR19
Locus tag EKH72_RS09770 Protein ID WP_025548916.1
Coordinates 1880192..1880494 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U3A269
Locus tag EKH72_RS09775 Protein ID WP_005448240.1
Coordinates 1880482..1880739 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EKH72_RS09720 1875717..1876130 - 414 WP_129830232.1 hypothetical protein -
EKH72_RS09725 1876164..1876256 - 93 WP_129830233.1 DUF3265 domain-containing protein -
EKH72_RS09730 1876342..1877592 + 1251 WP_129830234.1 ATP-binding protein -
EKH72_RS09735 1877592..1878287 + 696 WP_129830235.1 hypothetical protein -
EKH72_RS09740 1878329..1878421 - 93 WP_080251748.1 DUF3265 domain-containing protein -
EKH72_RS09745 1878460..1878660 - 201 WP_129830217.1 hypothetical protein -
EKH72_RS09755 1879041..1879397 - 357 WP_129830236.1 hypothetical protein -
EKH72_RS09760 1879444..1879575 - 132 WP_080338381.1 DUF3265 domain-containing protein -
EKH72_RS09765 1879662..1879964 + 303 WP_045588456.1 hypothetical protein -
EKH72_RS09770 1880192..1880494 - 303 WP_025548916.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EKH72_RS09775 1880482..1880739 - 258 WP_005448240.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EKH72_RS09780 1880821..1880913 - 93 WP_129830237.1 DUF3265 domain-containing protein -
EKH72_RS09785 1880928..1881839 - 912 WP_129830238.1 restriction endonuclease -
EKH72_RS09790 1881941..1882033 - 93 WP_074050578.1 DUF3265 domain-containing protein -
EKH72_RS26585 1882057..1882779 - 723 WP_206379533.1 hypothetical protein -
EKH72_RS09800 1882891..1883721 - 831 WP_069501215.1 abortive infection family protein -
EKH72_RS09805 1883816..1883926 - 111 WP_129830526.1 DUF3265 domain-containing protein -
EKH72_RS09810 1883923..1884432 - 510 WP_129830239.1 hypothetical protein -
EKH72_RS09815 1884589..1884873 - 285 WP_129830240.1 hypothetical protein -
EKH72_RS09820 1885009..1885713 - 705 WP_102591159.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1775216..1907379 132163
- inside Integron - - 1789606..1894569 104963


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11669.57 Da        Isoelectric Point: 5.1765

>T116226 WP_025548916.1 NZ_CP034565:c1880494-1880192 [Vibrio parahaemolyticus]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLRKFLLSKQ

Download         Length: 303 bp

>T116226 NZ_CP034565:c1880494-1880192 [Vibrio parahaemolyticus]
ATGGCTGAAATAATCTGGACTGAGCCAGCGTTATCTGACCTCAATGATATCGCTGAATACATCGCACTTGAAAATATTGT
TGCGGCAAAGCAGTTAGTACAAACGATCTTCTCCAAAGTCGAACGCCTACAAACTTTCCCAGAGTCAGGTCGTATTCCAC
CCGAACTAGAACATTTAAGTTATCGTGAAGTTGTCGTTAATCCATGTCGTGTTTTCTATAAGCAAGACGGCGACAAGGTG
TTTATTCTGTTTGTTATGCGTGCTGAGAGAGATTTACGCAAGTTCTTGTTGAGTAAGCAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9606.10 Da        Isoelectric Point: 6.7269

>AT116226 WP_005448240.1 NZ_CP034565:c1880739-1880482 [Vibrio parahaemolyticus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK

Download         Length: 258 bp

>AT116226 NZ_CP034565:c1880739-1880482 [Vibrio parahaemolyticus]
ATGAAAGTAGAACTAGTTACATCACTTAAGCGTCAAGCAACTAAGATCCTCGCCGATCTCCACGACACTAAAGAGCCAGT
GTTAATTACCGAGCATGGTAAGCCATCCGCGTATCTAGTTGATGTTGATGATTACGAGTTTATGCAAAATCGTTTGGCTA
TTCTTGAGGGTATCGCACGAGGTGAACGCGCGCTAGCTGACGGTAAAGTGGTAAGTCATGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR19

Antitoxin

Source ID Structure
AlphaFold DB A0A432DGX8

References