Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE(toxin) |
| Location | 1851984..1852543 | Replicon | chromosome |
| Accession | NZ_CP034565 | ||
| Organism | Vibrio parahaemolyticus strain D3112 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | EKH72_RS09475 | Protein ID | WP_029796919.1 |
| Coordinates | 1852265..1852543 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | U2ZGZ5 |
| Locus tag | EKH72_RS09470 | Protein ID | WP_005497249.1 |
| Coordinates | 1851984..1852268 (+) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EKH72_RS09420 | 1847282..1847404 | - | 123 | WP_080279199.1 | DUF3265 domain-containing protein | - |
| EKH72_RS09425 | 1847401..1847925 | - | 525 | WP_129830205.1 | GNAT family N-acetyltransferase | - |
| EKH72_RS09430 | 1847952..1848041 | - | 90 | WP_080265155.1 | DUF3265 domain-containing protein | - |
| EKH72_RS09435 | 1848761..1848910 | + | 150 | WP_129830206.1 | hypothetical protein | - |
| EKH72_RS26575 | 1848969..1849253 | - | 285 | WP_206379539.1 | hypothetical protein | - |
| EKH72_RS26580 | 1849272..1849418 | - | 147 | Protein_1654 | DUF3265 domain-containing protein | - |
| EKH72_RS09445 | 1849943..1850518 | - | 576 | WP_129830207.1 | hypothetical protein | - |
| EKH72_RS09455 | 1851041..1851130 | - | 90 | WP_129830522.1 | DUF3265 domain-containing protein | - |
| EKH72_RS09460 | 1851155..1851781 | - | 627 | WP_129830208.1 | hypothetical protein | - |
| EKH72_RS09470 | 1851984..1852268 | + | 285 | WP_005497249.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| EKH72_RS09475 | 1852265..1852543 | + | 279 | WP_029796919.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
| EKH72_RS09480 | 1852572..1852685 | - | 114 | WP_165384496.1 | DUF3265 domain-containing protein | - |
| EKH72_RS09490 | 1853120..1853212 | - | 93 | WP_005445734.1 | DUF3265 domain-containing protein | - |
| EKH72_RS09495 | 1853232..1854890 | - | 1659 | WP_129830210.1 | AAA family ATPase | - |
| EKH72_RS09500 | 1855037..1855894 | - | 858 | WP_129830211.1 | hypothetical protein | - |
| EKH72_RS09505 | 1856061..1856543 | - | 483 | WP_129830212.1 | MazG-related protein | - |
| EKH72_RS09510 | 1856693..1857160 | - | 468 | WP_129830213.1 | GNAT family N-acetyltransferase | - |
| EKH72_RS09515 | 1857199..1857291 | - | 93 | WP_129830214.1 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1775216..1907379 | 132163 | |
| - | inside | Integron | - | - | 1789606..1894569 | 104963 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10914.57 Da Isoelectric Point: 4.3697
>T116225 WP_029796919.1 NZ_CP034565:1852265-1852543 [Vibrio parahaemolyticus]
MILWEEESLNDREKIFEFLYDFNPEAADKTDDIIEAKVENLLEQPHMGVQRDGIRGRLLIIPEISMIVSYWIEGDIIRIM
RVLHQKQKFPAD
MILWEEESLNDREKIFEFLYDFNPEAADKTDDIIEAKVENLLEQPHMGVQRDGIRGRLLIIPEISMIVSYWIEGDIIRIM
RVLHQKQKFPAD
Download Length: 279 bp
>T116225 NZ_CP034565:1852265-1852543 [Vibrio parahaemolyticus]
ATGATTTTGTGGGAAGAAGAGTCTCTCAACGATCGCGAAAAGATATTTGAGTTTCTCTACGACTTCAACCCCGAAGCTGC
TGACAAAACCGACGATATTATTGAAGCAAAAGTTGAGAACCTTTTAGAGCAACCTCATATGGGAGTCCAACGTGACGGAA
TTAGAGGGCGATTGCTCATTATTCCTGAGATTTCGATGATTGTTTCATATTGGATTGAAGGTGATATCATTCGCATCATG
CGTGTACTGCACCAAAAACAAAAATTCCCAGCGGACTGA
ATGATTTTGTGGGAAGAAGAGTCTCTCAACGATCGCGAAAAGATATTTGAGTTTCTCTACGACTTCAACCCCGAAGCTGC
TGACAAAACCGACGATATTATTGAAGCAAAAGTTGAGAACCTTTTAGAGCAACCTCATATGGGAGTCCAACGTGACGGAA
TTAGAGGGCGATTGCTCATTATTCCTGAGATTTCGATGATTGTTTCATATTGGATTGAAGGTGATATCATTCGCATCATG
CGTGTACTGCACCAAAAACAAAAATTCCCAGCGGACTGA
Antitoxin
Download Length: 95 a.a. Molecular weight: 10913.25 Da Isoelectric Point: 9.1865
>AT116225 WP_005497249.1 NZ_CP034565:1851984-1852268 [Vibrio parahaemolyticus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLADQQRKTLSHDAWLTEQVNLAFEKFDSGKATFVDHESAKSR
MAERKAKIRNRGKL
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLADQQRKTLSHDAWLTEQVNLAFEKFDSGKATFVDHESAKSR
MAERKAKIRNRGKL
Download Length: 285 bp
>AT116225 NZ_CP034565:1851984-1852268 [Vibrio parahaemolyticus]
ATGGATACTAGAATTCAGTTTCGTGTTGATGAAGAAACGAAACGACTAGCCCAACAAATGGCTGAAAGCCAAGGCAGAAC
ACTAAGTGATGCTTGTCGTGAACTGACTGAGCAATTGGCTGACCAACAAAGAAAGACTTTATCTCACGACGCGTGGTTAA
CTGAACAAGTTAACTTAGCTTTTGAGAAGTTTGACTCAGGAAAAGCCACTTTTGTTGACCATGAGTCAGCTAAATCTCGT
ATGGCCGAGCGTAAAGCTAAAATCCGTAACCGAGGCAAATTATGA
ATGGATACTAGAATTCAGTTTCGTGTTGATGAAGAAACGAAACGACTAGCCCAACAAATGGCTGAAAGCCAAGGCAGAAC
ACTAAGTGATGCTTGTCGTGAACTGACTGAGCAATTGGCTGACCAACAAAGAAAGACTTTATCTCACGACGCGTGGTTAA
CTGAACAAGTTAACTTAGCTTTTGAGAAGTTTGACTCAGGAAAAGCCACTTTTGTTGACCATGAGTCAGCTAAATCTCGT
ATGGCCGAGCGTAAAGCTAAAATCCGTAACCGAGGCAAATTATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|