Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/Phd(antitoxin) |
| Location | 1837089..1837636 | Replicon | chromosome |
| Accession | NZ_CP034565 | ||
| Organism | Vibrio parahaemolyticus strain D3112 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A2K7SRN5 |
| Locus tag | EKH72_RS09315 | Protein ID | WP_010448451.1 |
| Coordinates | 1837089..1837391 (-) | Length | 101 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | U3A269 |
| Locus tag | EKH72_RS09320 | Protein ID | WP_005448240.1 |
| Coordinates | 1837379..1837636 (-) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EKH72_RS09255 | 1832409..1833305 | - | 897 | WP_129830190.1 | DUF4365 domain-containing protein | - |
| EKH72_RS09260 | 1833347..1833439 | - | 93 | WP_005526494.1 | DUF3265 domain-containing protein | - |
| EKH72_RS09265 | 1833454..1833963 | - | 510 | Protein_1623 | N-acetyltransferase | - |
| EKH72_RS09275 | 1834108..1834311 | - | 204 | WP_072606311.1 | hypothetical protein | - |
| EKH72_RS09285 | 1834577..1835041 | - | 465 | WP_129830193.1 | GIY-YIG nuclease family protein | - |
| EKH72_RS09290 | 1835068..1835160 | - | 93 | WP_080258646.1 | DUF3265 domain-containing protein | - |
| EKH72_RS09295 | 1835175..1835936 | - | 762 | WP_129830194.1 | hypothetical protein | - |
| EKH72_RS09305 | 1836576..1836923 | - | 348 | WP_129830196.1 | hypothetical protein | - |
| EKH72_RS09310 | 1836961..1837053 | - | 93 | WP_079758040.1 | DUF3265 domain-containing protein | - |
| EKH72_RS09315 | 1837089..1837391 | - | 303 | WP_010448451.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| EKH72_RS09320 | 1837379..1837636 | - | 258 | WP_005448240.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| EKH72_RS09325 | 1837888..1838313 | - | 426 | WP_129830197.1 | hypothetical protein | - |
| EKH72_RS09330 | 1838446..1838940 | - | 495 | WP_129830198.1 | GNAT family N-acetyltransferase | - |
| EKH72_RS09335 | 1839157..1840656 | + | 1500 | WP_129830199.1 | hypothetical protein | - |
| EKH72_RS09340 | 1840710..1840799 | - | 90 | WP_072615037.1 | DUF3265 domain-containing protein | - |
| EKH72_RS09345 | 1840831..1841199 | - | 369 | WP_024701877.1 | VOC family protein | - |
| EKH72_RS09350 | 1841229..1841396 | - | 168 | WP_089190283.1 | DUF3265 domain-containing protein | - |
| EKH72_RS09355 | 1841336..1841638 | - | 303 | WP_024699549.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1775216..1907379 | 132163 | |
| - | inside | Integron | - | - | 1789606..1894569 | 104963 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11625.52 Da Isoelectric Point: 5.1765
>T116224 WP_010448451.1 NZ_CP034565:c1837391-1837089 [Vibrio parahaemolyticus]
MAEVIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLRKFLLGKQ
MAEVIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLRKFLLGKQ
Download Length: 303 bp
>T116224 NZ_CP034565:c1837391-1837089 [Vibrio parahaemolyticus]
ATGGCTGAAGTAATCTGGACTGAACCAGCGTTATCTGACCTCAATGATATCGCTGAATACATAGCACTTGAAAATATAGT
AGCTGCAAAGCAGTTAGTACAAACGATCTTCTCCAAAGTCGAACGCCTACAAACTTTCCCAGAGTCAGGTCGTATTCCAC
CCGAGCTAGAACATTTAAGTTATCGTGAAGTTGTCGTTAATCCATGTCGTGTGTTCTATAAACAAGACGGTGACAAAGTG
TTTATTCTGTTTGTTATGCGTGCAGAGAGAGATTTGCGTAAGTTCTTGTTGGGTAAGCAATAG
ATGGCTGAAGTAATCTGGACTGAACCAGCGTTATCTGACCTCAATGATATCGCTGAATACATAGCACTTGAAAATATAGT
AGCTGCAAAGCAGTTAGTACAAACGATCTTCTCCAAAGTCGAACGCCTACAAACTTTCCCAGAGTCAGGTCGTATTCCAC
CCGAGCTAGAACATTTAAGTTATCGTGAAGTTGTCGTTAATCCATGTCGTGTGTTCTATAAACAAGACGGTGACAAAGTG
TTTATTCTGTTTGTTATGCGTGCAGAGAGAGATTTGCGTAAGTTCTTGTTGGGTAAGCAATAG
Antitoxin
Download Length: 86 a.a. Molecular weight: 9606.10 Da Isoelectric Point: 6.7269
>AT116224 WP_005448240.1 NZ_CP034565:c1837636-1837379 [Vibrio parahaemolyticus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK
Download Length: 258 bp
>AT116224 NZ_CP034565:c1837636-1837379 [Vibrio parahaemolyticus]
ATGAAAGTAGAACTAGTTACATCACTCAAACGTCAAGCAACTAAGATCCTCGCCGATCTCCACGACACCAAAGAACCAGT
GTTAATTACTGAGCATGGTAAGCCATCTGCGTATCTAGTTGATGTTGATGACTACGAATTTATGCAAAATCGTTTAGCTA
TTCTTGAGGGTATTGCACGAGGTGAGCGTGCACTAGCTGATGGTAAAGTGGTAAGTCATGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAGTAA
ATGAAAGTAGAACTAGTTACATCACTCAAACGTCAAGCAACTAAGATCCTCGCCGATCTCCACGACACCAAAGAACCAGT
GTTAATTACTGAGCATGGTAAGCCATCTGCGTATCTAGTTGATGTTGATGACTACGAATTTATGCAAAATCGTTTAGCTA
TTCTTGAGGGTATTGCACGAGGTGAGCGTGCACTAGCTGATGGTAAAGTGGTAAGTCATGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2K7SRN5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A432DGX8 |