Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 1822089..1822605 Replicon chromosome
Accession NZ_CP034565
Organism Vibrio parahaemolyticus strain D3112

Toxin (Protein)


Gene name relB Uniprot ID U2ZZV8
Locus tag EKH72_RS09125 Protein ID WP_005464459.1
Coordinates 1822089..1822358 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A7W4CB60
Locus tag EKH72_RS09130 Protein ID WP_005483180.1
Coordinates 1822351..1822605 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EKH72_RS09070 1817161..1817613 - 453 Protein_1588 NUDIX domain-containing protein -
EKH72_RS09075 1817725..1818513 - 789 WP_129830180.1 hypothetical protein -
EKH72_RS09080 1818584..1818673 - 90 WP_076665338.1 DUF3265 domain-containing protein -
EKH72_RS09085 1818705..1819073 - 369 WP_024701877.1 VOC family protein -
EKH72_RS09090 1819225..1819728 - 504 WP_025502540.1 peptide deformylase -
EKH72_RS09095 1819766..1819855 - 90 WP_079856741.1 DUF3265 domain-containing protein -
EKH72_RS09100 1819873..1820181 - 309 WP_025502574.1 hypothetical protein -
EKH72_RS09105 1820226..1820318 - 93 WP_072609951.1 DUF3265 domain-containing protein -
EKH72_RS09110 1820333..1821100 - 768 WP_129830181.1 FRG domain-containing protein -
EKH72_RS26570 1821131..1821223 - 93 WP_080252024.1 DUF3265 domain-containing protein -
EKH72_RS09120 1821238..1821927 - 690 WP_025502548.1 hypothetical protein -
EKH72_RS09125 1822089..1822358 - 270 WP_005464459.1 Txe/YoeB family addiction module toxin Toxin
EKH72_RS09130 1822351..1822605 - 255 WP_005483180.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
EKH72_RS09140 1822826..1823110 - 285 WP_129830182.1 nucleotide pyrophosphohydrolase -
EKH72_RS09150 1823556..1823687 - 132 WP_074050600.1 DUF3265 domain-containing protein -
EKH72_RS26430 1824175..1824342 - 168 WP_165384459.1 DUF3265 domain-containing protein -
EKH72_RS09165 1824282..1824584 - 303 WP_063517535.1 hypothetical protein -
EKH72_RS26435 1824645..1824893 - 249 WP_165384458.1 hypothetical protein -
EKH72_RS09170 1825028..1825138 - 111 WP_077672552.1 DUF3265 domain-containing protein -
EKH72_RS09175 1825147..1825623 - 477 WP_077672543.1 GNAT family N-acetyltransferase -
EKH72_RS09180 1825651..1825743 - 93 WP_129830183.1 DUF3265 domain-containing protein -
EKH72_RS09185 1825769..1826422 - 654 WP_129830184.1 hypothetical protein -
EKH72_RS09190 1826566..1827270 - 705 WP_102591159.1 class I SAM-dependent methyltransferase -
EKH72_RS09195 1827321..1827413 - 93 WP_129830185.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1775216..1907379 132163
- inside Integron - - 1789606..1894569 104963


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(10-89)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10614.96 Da        Isoelectric Point: 7.9816

>T116223 WP_005464459.1 NZ_CP034565:c1822358-1822089 [Vibrio parahaemolyticus]
MSSSQRLLSWTDDAWDDYLYWQTQDKKTLKRINKLINDVKRSPFEGIGKPEPLKENLSGFWSRRIDDTNRLVYAVDDQAI
TIISCRYHY

Download         Length: 270 bp

>T116223 NZ_CP034565:c1822358-1822089 [Vibrio parahaemolyticus]
ATGAGTAGTAGTCAACGTTTATTATCGTGGACTGATGATGCTTGGGATGACTACCTGTATTGGCAAACTCAAGACAAGAA
AACACTCAAGCGCATCAATAAACTCATCAATGATGTTAAGCGCTCTCCATTTGAGGGCATTGGTAAACCAGAGCCGTTAA
AAGAGAACTTATCTGGTTTTTGGTCTCGTCGTATTGATGATACTAATAGGCTTGTTTACGCAGTCGATGATCAAGCGATA
ACGATAATTTCATGTCGTTACCACTACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9481.66 Da        Isoelectric Point: 5.0623

>AT116223 WP_005483180.1 NZ_CP034565:c1822605-1822351 [Vibrio parahaemolyticus]
MRIVSFTEARNGLKAVLDGVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPQNVEHLNRSIAQYRAGKTTARE
LIDE

Download         Length: 255 bp

>AT116223 NZ_CP034565:c1822605-1822351 [Vibrio parahaemolyticus]
ATGAGAATCGTATCTTTTACTGAAGCTAGAAATGGTCTCAAAGCTGTTTTAGACGGTGTAGTTAATGATGCTGATACAAC
AGTTATTACACGCCGTGATTCTGAGGATGCAGTGGTTATGTCTTTAGACTACTACAATAGCCTTATGGAGACTGTTCATT
TACTACGCTCTCCTCAAAACGTTGAACACCTAAACCGTTCGATAGCACAGTACCGCGCTGGTAAAACAACAGCACGAGAG
TTAATTGATGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U2ZZV8

Antitoxin

Source ID Structure
AlphaFold DB A0A7W4CB60

References