Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 2441942..2443692 Replicon chromosome
Accession NZ_CP034554
Organism Burkholderia cepacia ATCC 25416

Toxin (Protein)


Gene name doc Uniprot ID A0A806V0L2
Locus tag EJ998_RS29665 Protein ID WP_027789380.1
Coordinates 2442796..2443692 (-) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A4S5DGT0
Locus tag EJ998_RS29660 Protein ID WP_027789379.1
Coordinates 2441942..2442799 (-) Length 286 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJ998_RS29640 2437105..2438595 - 1491 WP_027789375.1 aldehyde dehydrogenase -
EJ998_RS29645 2438668..2439495 - 828 WP_027789376.1 aspartate dehydrogenase -
EJ998_RS29650 2439488..2441155 - 1668 WP_027789377.1 thiamine pyrophosphate-binding protein -
EJ998_RS29655 2441148..2441945 - 798 WP_027789378.1 SDR family oxidoreductase -
EJ998_RS29660 2441942..2442799 - 858 WP_027789379.1 IclR family transcriptional regulator Antitoxin
EJ998_RS29665 2442796..2443692 - 897 WP_027789380.1 alpha/beta fold hydrolase Toxin
EJ998_RS29670 2443711..2444238 - 528 WP_021161513.1 cupin domain-containing protein -
EJ998_RS29675 2444272..2445042 - 771 WP_027789381.1 SDR family oxidoreductase -
EJ998_RS29680 2445035..2446105 - 1071 WP_027789382.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
EJ998_RS29685 2446160..2446471 - 312 WP_027789383.1 hypothetical protein -
EJ998_RS29690 2446475..2446792 - 318 WP_027789384.1 non-heme iron oxygenase ferredoxin subunit -
EJ998_RS29695 2447238..2448317 + 1080 WP_027789386.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-279)

Antitoxin

Transcription regulator IclR, C-terminal

(143-266)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30635.82 Da        Isoelectric Point: 7.7327

>T116217 WP_027789380.1 NZ_CP034554:c2443692-2442796 [Burkholderia cepacia ATCC 25416]
MSVIDKRERDRTATFAALLGQFPEQRCAAGAAGTIGYREAGAQHAGRALPVVLLHGIGSGAASWVSQLDTLGASRRVLAW
DAPGYGVSTPVHGASPAAADYAASLNAWLEALGIERCVLVGHSLGAIVAGGLARVMPARIAGLLLVSPAGGYGSAPAETR
ESRRDARLAMLAELGPAGLAEQRSGNMLSGFANEEARAWVRWNMARIVPAGYAQATHLLANADLATDLAGFRGRTAVAVG
ANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPAVYSALIDSFCRQCDQQRGLA

Download         Length: 897 bp

>T116217 NZ_CP034554:c2443692-2442796 [Burkholderia cepacia ATCC 25416]
ATGAGTGTCATCGACAAACGTGAGCGCGACCGCACCGCGACGTTCGCCGCGCTGCTCGGGCAGTTTCCCGAGCAGCGTTG
CGCGGCCGGCGCGGCGGGCACGATCGGTTACCGTGAGGCCGGCGCGCAGCATGCGGGCCGTGCGCTGCCCGTCGTGCTGC
TGCACGGCATCGGCTCGGGCGCCGCATCGTGGGTCAGCCAGCTCGACACGCTCGGCGCATCGCGGCGCGTGCTCGCGTGG
GACGCGCCCGGTTACGGCGTGTCGACGCCCGTGCACGGCGCGTCGCCGGCCGCCGCCGATTACGCGGCCTCGCTGAACGC
GTGGCTCGAGGCACTCGGCATCGAACGCTGCGTGCTGGTCGGCCATTCGCTCGGCGCGATCGTCGCGGGCGGTCTCGCCC
GCGTGATGCCCGCGCGGATCGCCGGCCTGCTGCTGGTGTCGCCCGCGGGCGGCTACGGCAGCGCACCGGCCGAAACGCGC
GAATCGCGCCGCGACGCACGGCTCGCGATGCTCGCCGAACTCGGCCCGGCCGGGCTCGCCGAGCAGCGCAGCGGCAACAT
GCTGTCCGGTTTCGCGAACGAGGAGGCACGTGCGTGGGTGCGCTGGAACATGGCGCGCATCGTGCCGGCCGGTTACGCGC
AGGCCACGCATCTGCTCGCGAACGCCGATCTCGCGACCGATCTCGCCGGCTTTCGCGGTCGCACGGCCGTGGCCGTCGGC
GCGAACGACGCGATCACGCCGCCCGCCGCGTGCGAGCGGATCGCCGCGGCCGCGCACGTCGGGCTGCAGGTGATTCCGCA
AGCCGGGCATGCCGGTTATGTCGAGGCTCCGGCCGTCTATTCCGCACTGATCGACTCGTTCTGCCGTCAGTGCGACCAAC
AGCGGGGGCTGGCATGA

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31511.04 Da        Isoelectric Point: 6.5068

>AT116217 WP_027789379.1 NZ_CP034554:c2442799-2441942 [Burkholderia cepacia ATCC 25416]
MNEPLQRPEPENDKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQSPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELHALYPEGTLNRMTNATPETVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNETQKIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFMKALGLR

Download         Length: 858 bp

>AT116217 NZ_CP034554:c2442799-2441942 [Burkholderia cepacia ATCC 25416]
ATGAACGAACCGCTGCAACGACCCGAACCCGAAAACGACAAGGCCGAAGCCAGCTACGTGGTGCCCGGCCTCGAACGCGG
GCTGCGGATCCTCGCCGAATTCTCGCCGCGCGAGCCCGTGCTCGGCGCGCCCGAGCTGTCGAAGCGGCTCGGCATTCCGC
GCACGACGGTGTTCCGCCTGCTGCAGACGCTCGAGTCGCTCGGCTTCCTCGAGCGCGCGGACAAGGATCGCAACTACAAG
CTCGGCATCGCCGTGCTGCGGCTCGGCTTCGAATACCTGAGCTCGCTGGAGCTGACCGATCTTGGCCTGCCCGTGATCGA
GAGCCTGCGCGACGCCACCGGCTTCACGACGCACATCGTGATCCGCGACGGCCGCGACGTGGTGTTCGTCGCGAAGGCGC
AGAGCCAGTCGCCGGTGTTCAGCTCGATCCGCGTGAACGTCGGCACGCGCTTGCCCGCGCATGCGACGACACACGGCCAC
GTGCTGATGGGCGACCTGTCGCTGAAGGAACTGCATGCGCTCTATCCGGAAGGCACGCTGAACCGGATGACGAACGCGAC
ACCGGAAACGGTCGACGCACTGTACGAAGTGATCCGCGAGGATGCGCTGCGCGGCTACGGCGTCAGCAATTCGTCGTTCG
AGCGCGGCATCTCGGTGGTCACGGCGCCGGTGCGCAACGAGACGCAGAAGATCGTCGCGTGCATCACGGTGACGGTGCCG
CGGCCGGAGATCGACGCGGCGCTGATCGCCGACGGGCTGATCGACAAGGTGCAGCGCGCGGCGGCGGAACTGTCGCGGCG
GCTCAATTACCGCTCGGATGACGAGCACACGTTTATGAAAGCATTAGGACTCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806V0L2

Antitoxin

Source ID Structure
AlphaFold DB A0A4S5DGT0

References