Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1936122..1936795 Replicon chromosome
Accession NZ_CP034553
Organism Burkholderia cepacia ATCC 25416

Toxin (Protein)


Gene name vagD Uniprot ID A0A0J5X1U9
Locus tag EJ998_RS09485 Protein ID WP_027787436.1
Coordinates 1936379..1936795 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A4S5D574
Locus tag EJ998_RS09480 Protein ID WP_049096496.1
Coordinates 1936122..1936382 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJ998_RS09465 1931677..1933929 + 2253 WP_027787439.1 TonB-dependent siderophore receptor -
EJ998_RS09470 1934016..1934855 + 840 WP_027787438.1 N(5)-hydroxyornithine transformylase PvdF -
EJ998_RS09475 1934855..1935871 + 1017 WP_027787437.1 acetyltransferase -
EJ998_RS09480 1936122..1936382 + 261 WP_049096496.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
EJ998_RS09485 1936379..1936795 + 417 WP_027787436.1 PIN domain-containing protein Toxin
EJ998_RS09490 1936850..1937755 - 906 WP_027787435.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
EJ998_RS09495 1937724..1938797 - 1074 WP_027787434.1 hypothetical protein -
EJ998_RS09500 1939139..1940302 + 1164 WP_027787433.1 amidohydrolase -
EJ998_RS09505 1940456..1940995 + 540 WP_027787432.1 outer membrane protein assembly factor BamE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-130)

Antitoxin

SpoVT-AbrB domain

(7-54)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14536.66 Da        Isoelectric Point: 7.8895

>T116212 WP_027787436.1 NZ_CP034553:1936379-1936795 [Burkholderia cepacia ATCC 25416]
VTTLYMLDTNICSFIMRERPPVVLSRLQSCVNAQHRIVVSAITYAEMRFGAVGRKASPKHAELVTAFVSRLDGVLSWDTA
AVDATAAIRADLAARGTPIGANDASIAGHAIAAGAVLVTNNGREFGRVAGLSLEDWAA

Download         Length: 417 bp

>T116212 NZ_CP034553:1936379-1936795 [Burkholderia cepacia ATCC 25416]
GTGACCACGCTCTACATGCTCGATACGAACATCTGTTCGTTCATCATGCGCGAGCGGCCGCCGGTAGTGCTGTCGCGGCT
GCAATCGTGCGTCAATGCGCAGCACCGGATCGTCGTGTCGGCCATCACTTATGCCGAAATGCGGTTCGGCGCAGTCGGCA
GGAAGGCGTCGCCGAAGCATGCGGAACTCGTGACGGCCTTTGTCTCGCGGCTCGATGGCGTGCTGTCGTGGGATACGGCG
GCCGTCGATGCGACGGCCGCGATTCGTGCCGATCTCGCCGCGCGCGGCACGCCGATCGGTGCGAACGATGCGTCGATCGC
CGGGCATGCGATCGCCGCCGGTGCGGTGCTCGTCACGAACAACGGCCGGGAATTCGGCCGGGTGGCCGGGTTGTCGCTCG
AAGACTGGGCGGCCTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9564.84 Da        Isoelectric Point: 4.6151

>AT116212 WP_049096496.1 NZ_CP034553:1936122-1936382 [Burkholderia cepacia ATCC 25416]
MRTVSIFKNARNQAIRIPKDMEFEGVTELEIRREGDTLMLRPVRPTWLSFASEPLADADFLAERPAVIESGRFDLSGGAA
PTESGQ

Download         Length: 261 bp

>AT116212 NZ_CP034553:1936122-1936382 [Burkholderia cepacia ATCC 25416]
ATGCGTACCGTTTCCATTTTCAAGAACGCCCGTAACCAGGCAATCCGCATCCCGAAGGACATGGAGTTCGAGGGGGTGAC
GGAACTCGAGATCCGCCGCGAGGGCGACACACTGATGCTGCGGCCGGTGCGGCCCACGTGGCTCTCGTTCGCGAGCGAAC
CGCTGGCCGACGCCGATTTCCTCGCCGAACGCCCGGCCGTGATCGAGTCCGGCCGCTTCGACCTTTCCGGCGGCGCCGCG
CCGACGGAGTCCGGCCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J5X1U9

Antitoxin

Source ID Structure
AlphaFold DB A0A4S5D574

References