Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-vagC/VapC-VagC
Location 187466..188103 Replicon chromosome
Accession NZ_CP034553
Organism Burkholderia cepacia ATCC 25416

Toxin (Protein)


Gene name vapC Uniprot ID A0A806UUZ0
Locus tag EJ998_RS00885 Protein ID WP_027788677.1
Coordinates 187702..188103 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A1Z3YWA1
Locus tag EJ998_RS00880 Protein ID WP_027788678.1
Coordinates 187466..187702 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJ998_RS00860 183444..184586 - 1143 WP_049097352.1 ADP-heptose--LPS heptosyltransferase -
EJ998_RS00865 184583..186286 - 1704 WP_027788681.1 thiamine pyrophosphate-binding protein -
EJ998_RS00870 186587..187048 + 462 WP_027788680.1 hypothetical protein -
EJ998_RS00875 187045..187329 + 285 WP_027788679.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
EJ998_RS00880 187466..187702 + 237 WP_027788678.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
EJ998_RS00885 187702..188103 + 402 WP_027788677.1 type II toxin-antitoxin system VapC family toxin Toxin
EJ998_RS00890 188170..189558 - 1389 WP_027788676.1 L-serine ammonia-lyase -
EJ998_RS00895 189589..190725 - 1137 WP_027788675.1 alginate lyase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin

SpoVT-AbrB domain

(7-46)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14959.06 Da        Isoelectric Point: 5.1684

>T116211 WP_027788677.1 NZ_CP034553:187702-188103 [Burkholderia cepacia ATCC 25416]
MPRYMLDTNMCIYLMKNQPEQVAKQFAQCYTGDVVMSAITYAELEYGVAACANPARERRHLAALIDDIPVAPFDVAAAQA
YGPVRDATRERKRDHLDKLIAAHAVSLDVALVTNNERDFVSYPGLRLENWLND

Download         Length: 402 bp

>T116211 NZ_CP034553:187702-188103 [Burkholderia cepacia ATCC 25416]
ATGCCGCGCTACATGCTCGACACCAACATGTGCATCTATCTGATGAAGAACCAGCCCGAGCAAGTCGCGAAACAATTTGC
GCAGTGCTACACGGGGGATGTGGTGATGTCGGCGATCACGTATGCCGAGCTCGAGTACGGCGTCGCCGCATGTGCGAATC
CTGCGCGGGAGCGTCGCCATCTCGCCGCGCTGATCGACGATATCCCCGTTGCTCCGTTCGACGTCGCGGCGGCGCAAGCG
TACGGTCCGGTCCGCGACGCAACCCGCGAGCGGAAGAGGGATCATCTCGACAAGCTGATCGCCGCGCACGCGGTGTCGCT
CGACGTTGCGCTCGTGACCAACAACGAGCGGGATTTCGTCAGCTATCCGGGATTGCGGCTGGAGAACTGGCTGAACGATT
GA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9144.34 Da        Isoelectric Point: 5.1974

>AT116211 WP_027788678.1 NZ_CP034553:187466-187702 [Burkholderia cepacia ATCC 25416]
MHTTKVFRNGNSQAVRIPADLAYERNDIELEIERIGDEIRIRPMRRPLTRVLEKFAKFGPDFMAEGRGDQEQADREEL

Download         Length: 237 bp

>AT116211 NZ_CP034553:187466-187702 [Burkholderia cepacia ATCC 25416]
ATGCACACGACGAAGGTATTTCGGAACGGCAACTCGCAGGCCGTGCGAATTCCTGCCGACCTCGCCTATGAGCGTAACGA
TATCGAACTGGAAATCGAGCGTATCGGTGACGAAATCCGTATTCGACCGATGCGGCGGCCGTTGACCCGCGTACTCGAGA
AGTTCGCGAAATTCGGGCCGGATTTCATGGCCGAAGGGCGCGGCGACCAGGAGCAGGCCGATCGCGAGGAGCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806UUZ0

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z3YWA1

References