Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1580848..1581412 Replicon chromosome
Accession NZ_CP034550
Organism Saccharothrix syringae strain NRRL B-16468

Toxin (Protein)


Gene name mazF Uniprot ID A0A5Q0GV09
Locus tag EKG83_RS07500 Protein ID WP_033427529.1
Coordinates 1581065..1581412 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A5Q0GTS5
Locus tag EKG83_RS07495 Protein ID WP_033427530.1
Coordinates 1580848..1581078 (+) Length 77 a.a.

Genomic Context

EKG83_RS07475EKG83_RS07485EKG83_RS07490EKG83_RS07495EKG83_RS07500EKG83_RS07515EKG83_RS07520EKG83_RS07525EKG83_RS07470EKG83_RS07480EKG83_RS07505EKG83_RS07510EKG83_RS07530
Location: 1576762..1577451 (690 bp)
Type: Others
Protein ID: WP_051764359.1
Location: 1578500..1578883 (384 bp)
Type: Others
Protein ID: WP_051764354.1
Location: 1579011..1580825 (1815 bp)
Type: Others
Protein ID: WP_170191746.1
Location: 1580848..1581078 (231 bp)
Type: Antitoxin
Protein ID: WP_033427530.1
Location: 1581065..1581412 (348 bp)
Type: Toxin
Protein ID: WP_033427529.1
Location: 1583111..1583980 (870 bp)
Type: Others
Protein ID: WP_084715949.1
Location: 1583977..1584828 (852 bp)
Type: Others
Protein ID: WP_033427526.1
Location: 1584845..1585084 (240 bp)
Type: Others
Protein ID: WP_033427525.1
Location: 1576124..1576639 (516 bp)
Type: Others
Protein ID: WP_033427533.1
Location: 1577428..1578405 (978 bp)
Type: Others
Protein ID: WP_051764357.1
Location: 1581535..1581729 (195 bp)
Type: Others
Protein ID: WP_033427528.1
Location: 1581726..1582925 (1200 bp)
Type: Others
Protein ID: WP_033427527.1
Location: 1585206..1585796 (591 bp)
Type: Others
Protein ID: WP_033427524.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EKG83_RS074701576124..1576639-516WP_033427533.1hypothetical protein-
EKG83_RS074751576762..1577451+690WP_051764359.1TetR/AcrR family transcriptional regulator C-terminal domain-containing protein-
EKG83_RS074801577428..1578405-978WP_051764357.1LCP family protein-
EKG83_RS074851578500..1578883+384WP_051764354.1hypothetical protein-
EKG83_RS074901579011..1580825+1815WP_170191746.1glycosyltransferase-
EKG83_RS074951580848..1581078+231WP_033427530.1ribbon-helix-helix domain-containing proteinAntitoxin
EKG83_RS075001581065..1581412+348WP_033427529.1type II toxin-antitoxin system PemK/MazF family toxinToxin
EKG83_RS075051581535..1581729-195WP_033427528.1ferredoxin-
EKG83_RS075101581726..1582925-1200WP_033427527.1cytochrome P450-
EKG83_RS075151583111..1583980+870WP_084715949.1ABC transporter ATP-binding protein-
EKG83_RS075201583977..1584828+852WP_033427526.1ABC transporter permease-
EKG83_RS075251584845..1585084+240WP_033427525.1helix-turn-helix transcriptional regulator-
EKG83_RS075301585206..1585796-591WP_033427524.1TetR family transcriptional regulator-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12478.43 Da        Isoelectric Point: 11.2857

>T116207 WP_033427529.1 NZ_CP034550:1581065-1581412 [Saccharothrix syringae]
MRRGDIYWVDLEPVRGTEANKVRPAVVVSNDAANRAAGRGGRGVVTVVPITSNTTRVYPFQVLLPARDCGLDRDSKAQAE
QVRTVAAVRLRARIGGLPPAVLKQLDEALRIHLAL

Download         Length: 348 bp

>T116207 NZ_CP034550:1581065-1581412 [Saccharothrix syringae]
ATGCGGCGAGGTGACATCTACTGGGTGGACCTGGAGCCGGTGCGCGGCACCGAGGCCAACAAGGTCCGCCCGGCCGTGGT
CGTGAGCAACGACGCGGCGAACCGGGCCGCCGGGCGGGGCGGCCGGGGCGTGGTGACCGTCGTGCCGATCACCTCGAACA
CCACGCGGGTGTACCCGTTCCAGGTGCTCCTGCCCGCCAGGGACTGCGGCCTGGACAGGGACTCCAAGGCGCAGGCCGAG
CAGGTGCGCACGGTGGCCGCGGTCCGGCTCCGCGCCCGCATCGGCGGTCTGCCGCCCGCCGTGCTCAAGCAGTTGGACGA
GGCGCTGAGGATCCACCTCGCGCTCTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8536.38 Da        Isoelectric Point: 4.1589

>AT116207 WP_033427530.1 NZ_CP034550:1580848-1581078 [Saccharothrix syringae]
MKISVSLPEEDVEFVDRYLRQHRSASRSSVIHQAIALLREAGLENAYATAWEEWEAEGEADMWDVTASDGVVDAAR

Download         Length: 231 bp

>AT116207 NZ_CP034550:1580848-1581078 [Saccharothrix syringae]
ATGAAAATCAGTGTGAGCCTGCCCGAGGAAGACGTAGAGTTCGTTGATCGCTACCTGCGGCAACATCGCAGCGCCTCCAG
GTCCTCGGTGATCCACCAGGCGATCGCGCTGCTCCGCGAGGCCGGACTGGAGAACGCCTACGCCACCGCGTGGGAGGAGT
GGGAAGCCGAGGGGGAAGCCGACATGTGGGACGTGACCGCGTCAGACGGTGTCGTCGATGCGGCGAGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A5Q0GV09

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A5Q0GTS5

References