Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 2530526..2532294 Replicon chromosome
Accession NZ_CP034547
Organism Burkholderia cenocepacia strain YG-3

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag D5R55_RS35220 Protein ID WP_126369233.1
Coordinates 2530526..2531437 (+) Length 304 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag D5R55_RS35225 Protein ID WP_126369235.1
Coordinates 2531434..2532294 (+) Length 287 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D5R55_RS35190 2525897..2526976 - 1080 WP_126369226.1 porin -
D5R55_RS35195 2527421..2527738 + 318 WP_050011927.1 non-heme iron oxygenase ferredoxin subunit -
D5R55_RS35200 2527740..2528051 + 312 WP_126369228.1 hypothetical protein -
D5R55_RS35205 2528112..2529182 + 1071 WP_126369230.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
D5R55_RS35210 2529175..2529945 + 771 WP_126369231.1 SDR family oxidoreductase -
D5R55_RS35215 2529980..2530507 + 528 WP_011547424.1 cupin domain-containing protein -
D5R55_RS35220 2530526..2531437 + 912 WP_126369233.1 alpha/beta hydrolase Toxin
D5R55_RS35225 2531434..2532294 + 861 WP_126369235.1 IclR family transcriptional regulator Antitoxin
D5R55_RS35230 2532291..2533088 + 798 WP_126369237.1 SDR family oxidoreductase -
D5R55_RS35235 2533081..2534748 + 1668 WP_126369239.1 thiamine pyrophosphate-binding protein -
D5R55_RS35240 2534741..2535562 + 822 WP_126369241.1 aspartate dehydrogenase -
D5R55_RS35245 2535635..2537125 + 1491 WP_126369243.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(56-284)

Antitoxin

Transcription regulator IclR, N-terminal

(25-73)


Sequences

Toxin        


Download         Length: 304 a.a.        Molecular weight: 31180.39 Da        Isoelectric Point: 7.7328

>T116204 WP_126369233.1 NZ_CP034547:2530526-2531437 [Burkholderia cenocepacia]
MSVIDKRERDRTAAFAALLGQFPEQRCEAGAAGTIGYREAGAGEAGAQHAGRALPVVLLHGIGSGAASWVSQLDTLRASR
RVLAWDAPGYGVSTPVHGASPAAADYAAALNAWLEALGIERCVLVGHSLGAIIAGGLARVMPGRIAGLLLISPAGGYGSA
PADTRESRRDARLAMLAELGPAGLAEQRSGNMLSGNAPEEARAWVRWNMARIVPQGYAQATHLLANADLAADLAGFRGRT
AVAVGANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEQPAVYSSLIDGFCRQCDRQRGLA

Download         Length: 912 bp

>T116204 NZ_CP034547:2530526-2531437 [Burkholderia cenocepacia]
ATGAGTGTCATCGACAAACGCGAACGCGACCGCACCGCGGCGTTCGCCGCGCTGCTCGGACAGTTTCCCGAGCAGCGTTG
CGAAGCCGGCGCGGCAGGCACGATCGGCTACCGTGAGGCTGGCGCAGGCGAGGCCGGCGCGCAGCATGCGGGCCGCGCGC
TGCCCGTCGTGCTGCTGCACGGGATCGGCTCGGGCGCCGCATCGTGGGTGAGCCAGCTCGACACGCTGCGCGCATCGCGC
CGCGTGCTCGCGTGGGATGCGCCCGGTTACGGCGTGTCGACGCCCGTGCACGGCGCATCGCCGGCCGCCGCCGATTACGC
GGCGGCGCTGAACGCGTGGCTCGAGGCACTCGGCATCGAACGCTGCGTGCTGGTCGGTCATTCGCTCGGCGCGATCATCG
CGGGCGGTCTCGCCCGCGTGATGCCTGGGCGGATCGCCGGCCTGCTGCTGATTTCGCCCGCGGGCGGCTACGGCAGCGCA
CCGGCCGACACGCGCGAATCGCGCCGCGACGCGCGGCTCGCGATGCTCGCGGAACTCGGCCCGGCCGGGCTCGCCGAGCA
GCGCAGCGGCAACATGCTGTCCGGCAACGCGCCCGAGGAGGCGCGGGCGTGGGTGCGCTGGAACATGGCGCGCATCGTGC
CGCAAGGGTATGCGCAGGCCACGCATCTGCTGGCGAACGCGGATCTCGCGGCCGATCTCGCCGGCTTTCGCGGCCGCACG
GCCGTGGCCGTCGGCGCGAACGACGCGATCACGCCGCCCGCCGCGTGCGAGCGCATCGCCGCGGCGGCGCACGTCGGGCT
GCAAGTGATTCCGCAGGCGGGTCATGCGGGTTACGTCGAACAGCCGGCCGTTTATTCATCGCTGATCGACGGCTTCTGCC
GCCAATGCGATCGTCAACGGGGGCTGGCATGA

Antitoxin


Download         Length: 287 a.a.        Molecular weight: 31485.05 Da        Isoelectric Point: 7.4722

>AT116204 WP_126369235.1 NZ_CP034547:2531434-2532294 [Burkholderia cenocepacia]
MSEPLQRRQDADNAKAEAGYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNY
KLGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQSPVFSSIRVNVGTRLPAHATTHG
HVLMGDLSLKELHALYPEGALNRMTSATPQTVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNETQKIVACITVTV
PRPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFMKALGLR

Download         Length: 861 bp

>AT116204 NZ_CP034547:2531434-2532294 [Burkholderia cenocepacia]
ATGAGCGAACCGTTGCAACGACGGCAGGACGCGGACAACGCGAAGGCCGAAGCCGGCTACGTGGTGCCGGGCCTCGAACG
CGGGCTGCGCATCCTCGCCGAATTCTCGCCGCGCGAGCCCGTGCTCGGCGCGCCCGAACTGTCGAAGCGGCTCGGCATTC
CGCGCACGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCGCTCGGCTTTCTCGAACGCGCGGACAAGGATCGCAACTAC
AAGCTCGGCATCGCCGTGCTGCGGCTCGGTTTCGAATACCTGAGCTCGCTGGAATTGACCGACCTCGGGCTGCCGGTGAT
CGAGAGCCTGCGCGATGCGACCGGCTTCACGACGCATATCGTGATCCGCGACGGCCGCGACGTGGTGTTCGTCGCGAAGG
CGCAGAGCCAGTCGCCGGTGTTCAGCTCGATCCGCGTGAACGTCGGCACGCGGCTGCCCGCGCATGCGACGACGCACGGC
CACGTACTGATGGGCGATCTTTCGCTGAAGGAACTGCACGCGCTGTATCCGGAAGGCGCGCTGAACCGGATGACGAGCGC
GACGCCGCAAACGGTCGACGCGCTGTACGAAGTGATCCGCGAGGATGCGCTGCGCGGCTACGGCGTCAGCAATTCGTCGT
TCGAGCGCGGGATCTCGGTCGTCACGGCGCCGGTGCGCAACGAGACGCAGAAGATCGTCGCGTGCATCACGGTGACGGTG
CCGAGGCCGGAGATCGACGCGGCGCTGATCGCGGACGGGCTGATCGACAAGGTGCAGCGCGCGGCGGCGGAATTGTCGCG
GCGGCTCAATTACCGCTCGGATGACGAGCACACGTTCATGAAGGCTTTGGGACTCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References