Detailed information of TA system TA116203

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-RelB
• Location: 2276933..2277456
• Replicon: chromosome
• Accession: NZ_CP034547
• Organism: Burkholderia cenocepacia strain YG-3

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: D5R55_RS34055
• Protein ID: WP_126369014.1
• Coordinates: 2276933..2277199 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B1K8I6
• Locus tag: D5R55_RS34060
• Protein ID: WP_011547275.1
• Coordinates: 2277196..2277456 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D5R55_RS34030	2272231..2273469	-	1239	WP_126369009.1	diaminopimelate decarboxylase	-
D5R55_RS34035	2273578..2274492	+	915	WP_126369010.1	LysR family transcriptional regulator	-
D5R55_RS34040	2274552..2275151	+	600	WP_126369011.1	GNAT family N-acetyltransferase	-
D5R55_RS34045	2275272..2275850	-	579	WP_126369012.1	DUF4142 domain-containing protein	-
D5R55_RS34050	2276260..2276883	-	624	WP_126369013.1	HAD hydrolase-like protein	-
D5R55_RS34055	2276933..2277199	-	267	WP_126369014.1	Txe/YoeB family addiction module toxin	Toxin
D5R55_RS34060	2277196..2277456	-	261	WP_011547275.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
D5R55_RS34065	2277666..2278109	+	444	WP_126369015.1	GNAT family N-acetyltransferase	-
D5R55_RS34070	2278167..2278385	+	219	WP_006480837.1	DUF1653 domain-containing protein	-
D5R55_RS34075	2278392..2278850	-	459	WP_126369016.1	ATP synthase F1 subunit epsilon	-
D5R55_RS34080	2278861..2279730	-	870	WP_126369017.1	ATP synthase F1 subunit gamma	-
D5R55_RS34085	2279878..2280849	+	972	WP_126369018.1	phosphate acetyltransferase	-
D5R55_RS34090	2280861..2282081	+	1221	WP_126369019.1	acetate/propionate family kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10682.07 Da
• Isoelectric Point: 9.8248

>T116203 WP_126369014.1 NZ_CP034547:c2277199-2276933 [Burkholderia cenocepacia]
MSVRRVLFTSDAWDDYVYWQGRDRKTLRRINQLIRETRRTPFEGIGKPEPLKANLSGFWSRRIDDTNRLAYEADDLQIRI
VSCRYHYE

Nucleotide

• Length: 267 bp

>T116203 NZ_CP034547:c2277199-2276933 [Burkholderia cenocepacia]
ATGAGCGTACGTCGCGTGCTCTTTACTTCCGATGCATGGGATGACTATGTCTACTGGCAAGGGCGGGATCGCAAGACGCT
CAGGCGCATCAACCAGCTCATTCGCGAAACCCGGCGCACCCCGTTCGAAGGCATCGGCAAGCCCGAGCCGTTGAAAGCCA
ATCTCTCCGGCTTCTGGTCCCGCCGCATCGACGATACGAATCGTCTGGCCTACGAGGCCGACGACCTTCAAATCCGCATC
GTGTCCTGTCGCTACCATTACGAGTAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9745.00 Da
• Isoelectric Point: 6.0717

>AT116203 WP_011547275.1 NZ_CP034547:c2277456-2277196 [Burkholderia cenocepacia]
MRTIHFSDARGNLKTVIDQVVDDADVTLITRRDAPNAVIMSQDYYDSLMETVHLLRSPANVAHLERSIAQLRKGKAKEHK
LAEDDE

Nucleotide

• Length: 261 bp

>AT116203 NZ_CP034547:c2277456-2277196 [Burkholderia cenocepacia]
ATGCGCACGATTCATTTTTCGGATGCCCGCGGCAATCTAAAGACCGTCATCGACCAGGTCGTCGACGATGCGGACGTGAC
GCTCATCACGCGCCGCGATGCACCGAACGCCGTCATCATGTCGCAGGACTATTACGACAGCCTGATGGAGACGGTGCACT
TGCTGCGCTCGCCGGCCAACGTCGCCCATCTCGAACGTTCGATCGCGCAACTGCGCAAGGGCAAAGCGAAAGAACACAAG
CTCGCCGAGGATGATGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A1J9NJ62