Detailed information of TA system TA116202

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 2188941..2190168
• Replicon: chromosome
• Accession: NZ_CP034547
• Organism: Burkholderia cenocepacia strain YG-3

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: D5R55_RS33630
• Protein ID: WP_126368945.1
• Coordinates: 2188941..2189522 (-)
• Length: 194 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: D5R55_RS33635
• Protein ID: WP_126368946.1
• Coordinates: 2189602..2190168 (-)
• Length: 189 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D5R55_RS33615	2185287..2187341	-	2055	WP_126368943.1	MacB family efflux pump subunit	-
D5R55_RS33620	2187344..2188537	-	1194	WP_126368944.1	efflux RND transporter periplasmic adaptor subunit	-
D5R55_RS33630	2188941..2189522	-	582	WP_126368945.1	HD domain-containing protein	Toxin
D5R55_RS33635	2189602..2190168	-	567	WP_126368946.1	helix-turn-helix domain-containing protein	Antitoxin
D5R55_RS33640	2190216..2190854	-	639	WP_126368947.1	hypothetical protein	-
D5R55_RS33645	2191206..2192609	+	1404	WP_126368948.1	DUF308 domain-containing protein	-
D5R55_RS33650	2192703..2193278	+	576	WP_126368949.1	hypothetical protein	-
D5R55_RS33655	2193406..2194137	+	732	WP_006498851.1	ribonuclease T2	-
D5R55_RS33660	2194210..2194863	-	654	WP_126368950.1	cysteine hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HD domain (16-172)

Antitoxin

• Cro/C1-type helix-turn-helix domain (12-64)

Sequences

Toxin

Protein

• Length: 194 a.a.
• Molecular weight: 21477.09 Da
• Isoelectric Point: 5.1253

>T116202 WP_126368945.1 NZ_CP034547:c2189522-2188941 [Burkholderia cenocepacia]
MNPDTIRARLAFLREAERLKDVLRSGHTSAGRPESTAEHSWRLCLMAVVFADALPDVDTLKLLKLCVVHDLGEALHGDIP
AIEQAAHPDKSAHERDDLLTLTASLDRTLRDEIVALWDEYEAAASAEARAAKALDKLETILQHNQGSNPPDFDYAFNLDY
GRRYTDAAPLFRAIREIVDADTQRRIDAGGHRA

Nucleotide

• Length: 582 bp

>T116202 NZ_CP034547:c2189522-2188941 [Burkholderia cenocepacia]
ATGAATCCCGATACGATCCGCGCGCGGCTCGCTTTCCTGCGCGAAGCCGAACGCCTGAAGGACGTGCTGCGCAGCGGCCA
CACGTCGGCCGGACGCCCGGAAAGCACGGCCGAGCACAGCTGGCGGCTGTGCCTGATGGCGGTCGTGTTCGCCGACGCGC
TGCCCGACGTCGACACGCTGAAGCTGCTGAAGCTGTGCGTCGTCCACGACCTCGGCGAGGCGCTGCACGGCGACATCCCC
GCGATCGAGCAAGCCGCGCATCCCGACAAGAGCGCGCACGAACGCGACGACCTGCTGACGCTGACCGCGTCGCTCGACCG
CACGCTGCGCGACGAGATCGTCGCGCTGTGGGACGAATACGAGGCGGCCGCGTCGGCGGAGGCCCGCGCGGCGAAGGCGC
TCGACAAGCTCGAAACGATCCTGCAGCACAACCAGGGCAGCAATCCGCCCGATTTCGACTATGCGTTCAATCTCGACTAT
GGCCGGCGCTACACCGACGCCGCGCCGCTGTTCCGCGCGATCCGCGAGATAGTCGACGCGGATACGCAGCGCAGGATCGA
CGCGGGCGGACACCGCGCGTAA

Antitoxin

Protein

• Length: 189 a.a.
• Molecular weight: 20376.24 Da
• Isoelectric Point: 10.1932

>AT116202 WP_126368946.1 NZ_CP034547:c2190168-2189602 [Burkholderia cenocepacia]
MTASPLHTPSLGPQLKRWRALHRVKQSHAAELFGVAQSTISRWEAGLQQMSPDERATAERLLAARVDSAGDHALARLIAG
SAGRMHLVCDLTHRLLSSSPARAAEFAQPLSTLLGTSLWRYATLEIVSMEAALAPLGWHDRAGPPSVEFDTGANASRVVP
IRGSRCRWTRMTLSDGSAVRLVETLDAH

Nucleotide

• Length: 567 bp

>AT116202 NZ_CP034547:c2190168-2189602 [Burkholderia cenocepacia]
ATGACAGCCTCACCGCTTCATACGCCGTCGCTCGGCCCCCAACTCAAGCGCTGGCGCGCGCTGCACCGCGTGAAGCAAAG
CCACGCGGCCGAACTGTTCGGCGTCGCGCAATCGACGATCTCGCGCTGGGAGGCCGGCCTTCAGCAGATGTCGCCCGACG
AGCGGGCGACGGCCGAACGGCTGCTCGCCGCGCGCGTCGATTCGGCGGGCGACCATGCACTCGCGCGGCTGATCGCCGGC
AGCGCGGGCCGCATGCATCTCGTGTGCGACCTCACGCACCGTCTGCTCTCCAGTTCGCCAGCGCGCGCGGCCGAGTTCGC
GCAGCCGCTTTCGACGCTGCTCGGCACGTCGCTGTGGCGCTACGCGACACTGGAGATCGTAAGCATGGAAGCCGCGCTCG
CCCCGCTCGGCTGGCACGACCGCGCGGGGCCGCCGAGCGTCGAGTTCGACACCGGCGCGAATGCGTCGCGGGTCGTGCCG
ATTCGCGGCAGCCGATGCCGGTGGACGCGGATGACGCTGTCGGACGGCTCGGCCGTGCGGCTCGTGGAAACGCTCGACGC
CCACTGA