Detailed information of TA system TA116201

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1570471..1570990
• Replicon: chromosome
• Accession: NZ_CP034547
• Organism: Burkholderia cenocepacia strain YG-3

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A2X1HSN6
• Locus tag: D5R55_RS30870
• Protein ID: WP_059495132.1
• Coordinates: 1570709..1570990 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: D5R55_RS30865
• Protein ID: WP_126368490.1
• Coordinates: 1570471..1570719 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D5R55_RS30855	1567910..1569100	+	1191	WP_126368488.1	2-methylaconitate cis-trans isomerase PrpF	-
D5R55_RS30860	1569296..1570348	+	1053	WP_126368489.1	CoA transferase	-
D5R55_RS30865	1570471..1570719	+	249	WP_126368490.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
D5R55_RS30870	1570709..1570990	+	282	WP_059495132.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D5R55_RS30875	1571031..1571474	-	444	WP_011353771.1	PaaI family thioesterase	-
D5R55_RS30880	1571755..1573374	+	1620	WP_126368491.1	Tar ligand binding domain-containing protein	-
D5R55_RS30885	1573347..1574456	-	1110	WP_126368492.1	AGE family epimerase/isomerase	-
D5R55_RS30890	1574572..1575270	+	699	WP_126368493.1	MgtC/SapB family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-81)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (12-78)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10928.89 Da
• Isoelectric Point: 10.6474

>T116201 WP_059495132.1 NZ_CP034547:1570709-1570990 [Burkholderia cenocepacia]
MTFELAFLEPALKEWKKLDRTVRDQFKAKLAERLEHPRIPSAKLHGHPDRYKIKLRGVGYRLVYEVRDAEVIVLVVAVGR
RERDAVYLAAMKR

Nucleotide

• Length: 282 bp

>T116201 NZ_CP034547:1570709-1570990 [Burkholderia cenocepacia]
ATGACCTTTGAACTCGCCTTTCTCGAACCTGCATTGAAGGAGTGGAAGAAGCTCGATCGCACCGTGCGCGATCAATTCAA
GGCCAAGCTCGCCGAGCGGCTCGAGCATCCTCGTATCCCGTCAGCCAAATTGCATGGCCACCCGGATCGCTACAAGATCA
AGCTGCGTGGTGTCGGGTATCGCCTCGTCTACGAAGTGCGCGACGCGGAAGTCATCGTGCTGGTGGTCGCGGTCGGCCGC
CGCGAGCGTGATGCGGTTTATCTGGCTGCGATGAAACGCTAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8977.30 Da
• Isoelectric Point: 5.0636

>AT116201 WP_126368490.1 NZ_CP034547:1570471-1570719 [Burkholderia cenocepacia]
MPHTILASVTASVSELKRNPMGTVAAGEGFPVAILNHNEPAFYCIPAKTWEAMVERLEDVEDNALADSRAREKVVKVKLN
DL

Nucleotide

• Length: 249 bp

>AT116201 NZ_CP034547:1570471-1570719 [Burkholderia cenocepacia]
ATGCCTCACACCATTCTGGCGAGCGTGACGGCGAGCGTCTCGGAGCTGAAGCGGAATCCGATGGGAACCGTTGCCGCAGG
TGAAGGTTTTCCGGTCGCGATCCTGAATCACAACGAACCCGCGTTCTACTGCATTCCCGCGAAGACGTGGGAGGCGATGG
TCGAACGTTTGGAAGACGTCGAAGACAATGCGTTGGCCGATTCGCGCGCCAGGGAGAAGGTCGTCAAGGTTAAGCTGAAT
GACCTTTGA

Structures

Toxin

• AlphaFold DB: A0A2X1HSN6