Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 811547..812211 Replicon chromosome
Accession NZ_CP034546
Organism Burkholderia cenocepacia strain YG-3

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag D5R55_RS21040 Protein ID WP_164725469.1
Coordinates 811547..811843 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag D5R55_RS21045 Protein ID WP_126365429.1
Coordinates 811846..812211 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D5R55_RS21025 808034..809158 - 1125 WP_126365423.1 efflux RND transporter periplasmic adaptor subunit -
D5R55_RS21030 809241..809858 - 618 WP_126365425.1 TetR/AcrR family transcriptional regulator -
D5R55_RS21035 809936..811396 + 1461 WP_126365427.1 TolC family protein -
D5R55_RS21040 811547..811843 + 297 WP_164725469.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D5R55_RS21045 811846..812211 + 366 WP_126365429.1 putative addiction module antidote protein Antitoxin
D5R55_RS21050 812303..813862 - 1560 WP_126365431.1 cytochrome c -
D5R55_RS21055 813853..814254 - 402 WP_126365433.1 cytochrome C oxidase subunit I -
D5R55_RS21060 814251..816890 - 2640 WP_126365435.1 cytochrome c oxidase subunit I -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-97)

Antitoxin

Uncharacterized protein HI1420

(16-96)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10774.55 Da        Isoelectric Point: 9.9376

>T116198 WP_164725469.1 NZ_CP034546:811547-811843 [Burkholderia cenocepacia]
MFKVLTTPQFDKWLDGLRDPVGSAAISLPIERAKLGNLGQWRAIGDGVNEMKIDVGPGYRAYFVRRGKIIVVVLCGGDKS
TQKKDIKTAKQIAAELED

Download         Length: 297 bp

>T116198 NZ_CP034546:811547-811843 [Burkholderia cenocepacia]
ATGTTCAAAGTCCTGACCACTCCCCAATTTGACAAATGGCTCGATGGTCTTCGCGACCCGGTCGGCAGCGCCGCGATCAG
CCTGCCCATCGAGCGGGCGAAGCTCGGCAACCTTGGCCAGTGGCGTGCAATCGGCGACGGCGTCAACGAAATGAAGATCG
ATGTAGGGCCGGGGTACCGGGCCTACTTCGTGCGGCGCGGAAAGATAATCGTCGTGGTGTTGTGCGGTGGGGACAAGTCG
ACGCAGAAGAAGGACATCAAGACGGCGAAGCAAATCGCCGCCGAACTGGAGGATTGA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 12858.53 Da        Isoelectric Point: 7.4018

>AT116198 WP_126365429.1 NZ_CP034546:811846-812211 [Burkholderia cenocepacia]
MKISELAEFDGSKYLKDEDAIRHYLAQAFEDGDPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVAALGLHLTVAPTTQNAEAAPAPEPTSRTRSHARAAAHG

Download         Length: 366 bp

>AT116198 NZ_CP034546:811846-812211 [Burkholderia cenocepacia]
ATGAAAATCAGCGAACTGGCCGAATTCGATGGCTCGAAGTACCTGAAGGACGAGGACGCGATTCGTCACTACCTGGCGCA
GGCGTTTGAAGATGGAGATCCTCGACTGATCCAGGCCGCGCTCGGCAACGTCGCGAAGGCGCGCGGCATGACGGCGCTGG
CGCGCGAGTCCGGCGTGAAGCGTGAAGCGCTCTACCGTGCGCTGTCGGAAGGCGGGAACGCGGAGTTTGCAACGATCATG
AAGGTCGTCGCCGCGTTGGGATTGCATCTGACCGTTGCGCCGACCACGCAGAACGCCGAAGCAGCACCCGCGCCTGAACC
GACCTCGCGCACGCGCTCGCACGCACGTGCGGCGGCCCACGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References