Detailed information of TA system TA116197

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vagCD/VapC-VagC
• Location: 1885081..1885754
• Replicon: chromosome
• Accession: NZ_CP034545
• Organism: Burkholderia cenocepacia strain YG-3

Toxin (Protein)

• Gene name: vagD
• Uniprot ID: -
• Locus tag: D5R55_RS08955
• Protein ID: WP_126361422.1
• Coordinates: 1885338..1885754 (+)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: A0A4S5D574
• Locus tag: D5R55_RS08950
• Protein ID: WP_049096496.1
• Coordinates: 1885081..1885341 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D5R55_RS08935	1880625..1882886	+	2262	WP_126361412.1	TonB-dependent siderophore receptor	-
D5R55_RS08940	1882975..1883814	+	840	WP_126361416.1	N(5)-hydroxyornithine transformylase PvdF	-
D5R55_RS08945	1883814..1884830	+	1017	WP_126361419.1	acetyltransferase	-
D5R55_RS08950	1885081..1885341	+	261	WP_049096496.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
D5R55_RS08955	1885338..1885754	+	417	WP_126361422.1	PIN domain-containing protein	Toxin
D5R55_RS08960	1885803..1886708	-	906	WP_126361425.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
D5R55_RS08965	1886677..1887747	-	1071	WP_126364160.1	hypothetical protein	-
D5R55_RS08970	1888100..1889263	+	1164	WP_126361428.1	amidohydrolase	-
D5R55_RS08975	1889294..1890598	-	1305	WP_126361431.1	cobyrinate a,c-diamide synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-130)

Antitoxin

• SpoVT-AbrB domain (7-54)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 14594.80 Da
• Isoelectric Point: 7.8895

>T116197 WP_126361422.1 NZ_CP034545:1885338-1885754 [Burkholderia cenocepacia]
VTTLYMLDTNICSFIMRERPPVVLSRLQSCVNAQHRIVVSAITYAEMRFGAVGRKASPKHAELVTAFVSRLDGVLSWDTA
AVDATAAIRVDLAARGMPIGANDASIAGHAIAAGAVLVTNNGREFGRVAGLSLEDWAA

Nucleotide

• Length: 417 bp

>T116197 NZ_CP034545:1885338-1885754 [Burkholderia cenocepacia]
GTGACCACGCTCTACATGCTCGATACGAACATCTGTTCGTTCATCATGCGCGAGCGGCCGCCGGTAGTGCTTTCGCGGCT
GCAATCGTGCGTCAATGCGCAGCACCGGATCGTCGTGTCGGCCATCACTTATGCCGAAATGCGGTTCGGCGCAGTCGGCA
GGAAGGCGTCGCCGAAGCATGCGGAACTCGTGACGGCCTTTGTCTCGCGGCTCGATGGCGTGCTGTCGTGGGATACGGCG
GCCGTCGATGCAACGGCCGCGATTCGCGTCGATCTCGCCGCGCGCGGCATGCCGATCGGCGCGAACGATGCGTCGATCGC
CGGGCATGCGATCGCGGCCGGTGCGGTGCTCGTCACGAACAACGGCCGGGAGTTCGGCCGGGTGGCCGGGTTGTCGCTCG
AAGATTGGGCAGCCTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9564.84 Da
• Isoelectric Point: 4.6151

>AT116197 WP_049096496.1 NZ_CP034545:1885081-1885341 [Burkholderia cenocepacia]
MRTVSIFKNARNQAIRIPKDMEFEGVTELEIRREGDTLMLRPVRPTWLSFASEPLADADFLAERPAVIESGRFDLSGGAA
PTESGQ

Nucleotide

• Length: 261 bp

>AT116197 NZ_CP034545:1885081-1885341 [Burkholderia cenocepacia]
ATGCGCACCGTTTCCATTTTCAAGAACGCACGTAACCAGGCAATCCGCATCCCGAAGGACATGGAGTTCGAGGGGGTGAC
GGAACTCGAGATCCGCCGGGAGGGCGACACGCTGATGCTGCGGCCGGTGCGGCCCACGTGGCTCTCGTTCGCGAGCGAAC
CGCTGGCCGACGCCGATTTCCTCGCCGAACGCCCGGCCGTGATCGAGTCCGGCCGCTTCGACCTTTCCGGCGGCGCCGCG
CCGACGGAGTCCGGCCAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A4S5D574