Detailed information of TA system TA116196

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapC-vagC/VapC-VagC
• Location: 171663..172300
• Replicon: chromosome
• Accession: NZ_CP034545
• Organism: Burkholderia cenocepacia strain YG-3

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: D5R55_RS00795
• Protein ID: WP_126359113.1
• Coordinates: 171899..172300 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: -
• Locus tag: D5R55_RS00790
• Protein ID: WP_126359111.1
• Coordinates: 171663..171899 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D5R55_RS00775	167300..168316	+	1017	WP_126359105.1	helix-turn-helix domain-containing protein	-
D5R55_RS00780	168527..169624	-	1098	WP_126359107.1	ADP-heptose--LPS heptosyltransferase	-
D5R55_RS00785	169621..171324	-	1704	WP_126359109.1	thiamine pyrophosphate-binding protein	-
D5R55_RS00790	171663..171899	+	237	WP_126359111.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
D5R55_RS00795	171899..172300	+	402	WP_126359113.1	type II toxin-antitoxin system VapC family toxin	Toxin
D5R55_RS00800	172368..173756	-	1389	WP_126359115.1	L-serine ammonia-lyase	-
D5R55_RS00805	173787..174929	-	1143	WP_126359117.1	alginate lyase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-119)

Antitoxin

• SpoVT-AbrB domain (7-46)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14892.16 Da
• Isoelectric Point: 6.4718

>T116196 WP_126359113.1 NZ_CP034545:171899-172300 [Burkholderia cenocepacia]
MPRFMLDTNMCIYLMKIQPEQVARRFAQCCTGDVVMSAITYAELEYGVTACASPARERRNLAALIEDIPVAPFGAAAAQA
YGPVRDATRERKKDHLDKLIAAHAVSLDVVLVTNHERDFVSYPGLRLENWLHD

Nucleotide

• Length: 402 bp

>T116196 NZ_CP034545:171899-172300 [Burkholderia cenocepacia]
ATGCCGCGCTTCATGCTCGACACCAACATGTGCATCTATCTGATGAAAATTCAGCCGGAGCAGGTCGCGAGACGGTTTGC
GCAGTGCTGCACGGGCGACGTCGTCATGTCGGCGATCACCTATGCCGAGCTGGAATACGGCGTGACCGCATGCGCGAGCC
CTGCCCGGGAGCGCCGCAATCTTGCTGCGTTGATCGAGGATATTCCCGTCGCGCCTTTCGGCGCCGCGGCTGCGCAAGCA
TATGGCCCGGTCCGCGACGCCACCCGCGAGCGGAAGAAGGATCACCTCGACAAATTGATCGCCGCGCATGCGGTATCGCT
CGATGTCGTCCTCGTCACCAACCACGAGCGCGATTTCGTCAGCTATCCGGGGTTGCGGCTGGAGAACTGGCTGCACGACT
AG

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9098.27 Da
• Isoelectric Point: 5.7316

>AT116196 WP_126359111.1 NZ_CP034545:171663-171899 [Burkholderia cenocepacia]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERIGDEIRIRPMRRPLTQVLEKFAKFGPDFMTEGRGDHEQAEREGL

Nucleotide

• Length: 237 bp

>AT116196 NZ_CP034545:171663-171899 [Burkholderia cenocepacia]
ATGCATACCACGAGGGTATTCAGGAACGGCAACTCGCAGGCCGTGCGTATTCCTGCGGACCTTGCCTATGAGCGCAGTGA
TATCGAACTGGAAATCGAACGCATCGGTGACGAAATCCGCATTCGGCCGATGCGGCGGCCGTTGACTCAGGTACTGGAGA
AGTTCGCGAAATTCGGGCCGGACTTCATGACGGAAGGGCGTGGCGACCACGAGCAGGCCGAACGCGAGGGTTTGTGA