Detailed information of TA system TA116195

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1806621..1807229
• Replicon: chromosome
• Accession: NZ_CP034543
• Organism: Streptococcus periodonticum strain KCOM 2412

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: I0S7M8
• Locus tag: EHW89_RS08880
• Protein ID: WP_003038349.1
• Coordinates: 1806621..1806812 (+)
• Length: 64 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: I0S7P0
• Locus tag: EHW89_RS08885
• Protein ID: WP_003038371.1
• Coordinates: 1806849..1807229 (+)
• Length: 127 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EHW89_RS09435	1801948..1802115	+	168	WP_003075312.1	hypothetical protein	-
EHW89_RS08840	1802458..1802736	+	279	WP_003027794.1	hypothetical protein	-
EHW89_RS09440	1802733..1802909	+	177	WP_003027795.1	hypothetical protein	-
EHW89_RS08845	1802899..1803135	+	237	WP_003027797.1	hypothetical protein	-
EHW89_RS08850	1803132..1803467	+	336	WP_039677791.1	hypothetical protein	-
EHW89_RS08855	1803469..1803738	+	270	WP_003027800.1	hypothetical protein	-
EHW89_RS08860	1803747..1804538	+	792	WP_126467908.1	phage replisome organizer N-terminal domain-containing protein	-
EHW89_RS08865	1804553..1805404	+	852	WP_126467910.1	ATP-binding protein	-
EHW89_RS08870	1805653..1806081	+	429	WP_126467912.1	ArpU family transcriptional regulator	-
EHW89_RS08880	1806621..1806812	+	192	WP_003038349.1	type II toxin-antitoxin system HicA family toxin	Toxin
EHW89_RS08885	1806849..1807229	+	381	WP_003038371.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
EHW89_RS08890	1807780..1808220	+	441	WP_003032335.1	LytTR family transcriptional regulator	-
EHW89_RS08895	1808217..1808675	+	459	WP_126467914.1	DUF3021 domain-containing protein	-
EHW89_RS08900	1808855..1811413	-	2559	WP_126467916.1	DNA mismatch repair protein MutS	-
EHW89_RS08905	1811576..1812016	-	441	WP_126467918.1	arginine repressor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1791170..1807229	16059

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-62)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (5-108)

Sequences

Toxin

Protein

• Length: 64 a.a.
• Molecular weight: 7192.29 Da
• Isoelectric Point: 8.6749

>T116195 WP_003038349.1 NZ_CP034543:1806621-1806812 [Streptococcus periodonticum]
MPLTGKEMAKLAEKNGWVEIRQNGSHHHFKHEDFDYIVTIPIHGNKDLGRGLESKILKDLGLK

Nucleotide

• Length: 192 bp

>T116195 NZ_CP034543:1806621-1806812 [Streptococcus periodonticum]
ATGCCACTTACAGGAAAAGAAATGGCAAAGCTAGCCGAGAAAAACGGTTGGGTAGAAATCCGACAGAACGGCAGCCATCA
CCATTTCAAACATGAAGATTTTGATTATATAGTGACTATCCCAATCCATGGAAACAAGGATTTAGGAAGAGGGCTAGAAA
GCAAAATCCTGAAAGATTTGGGGCTGAAATAA

Antitoxin

Protein

• Length: 127 a.a.
• Molecular weight: 14150.14 Da
• Isoelectric Point: 4.5235

>AT116195 WP_003038371.1 NZ_CP034543:1806849-1807229 [Streptococcus periodonticum]
MLKSYPAIFHKEEDGSYWVEFPEFGGGTQGANVEEALKNAREMLESVLAAYIDEGLDMPKPSDIMALTVKDGFVSMIQAD
PTPFIRNNKAVRKNVTVPEWLVRLADREKVNYSEVLTQALETKLQA

Nucleotide

• Length: 381 bp

>AT116195 NZ_CP034543:1806849-1807229 [Streptococcus periodonticum]
ATGTTAAAATCATATCCAGCAATTTTTCATAAAGAGGAAGACGGTTCTTATTGGGTAGAATTTCCAGAGTTTGGAGGAGG
CACACAAGGGGCAAATGTTGAAGAAGCCTTGAAAAATGCCCGTGAAATGCTTGAGAGTGTTTTAGCTGCTTACATAGACG
AAGGATTAGATATGCCAAAGCCTAGCGACATCATGGCTTTAACCGTTAAAGACGGCTTTGTTAGCATGATACAAGCAGAC
CCTACCCCGTTTATTCGCAACAATAAAGCCGTTAGAAAGAATGTGACTGTCCCTGAATGGCTAGTAAGATTAGCGGATCG
TGAAAAAGTAAATTATTCTGAGGTGCTAACTCAAGCCCTAGAAACAAAGTTACAAGCCTAG

Structures

Toxin

• AlphaFold DB: I0S7M8

Antitoxin

• AlphaFold DB: I0S7P0