Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 537026..537658 Replicon chromosome
Accession NZ_CP034541
Organism Brevibacillus sp. SCSIO 07484

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag EJ378_RS02670 Protein ID WP_126425055.1
Coordinates 537308..537658 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag EJ378_RS02665 Protein ID WP_206514593.1
Coordinates 537026..537304 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJ378_RS02645 534013..535041 + 1029 WP_126425052.1 outer membrane lipoprotein-sorting protein -
EJ378_RS02650 534999..535121 + 123 Protein_510 hypothetical protein -
EJ378_RS02655 535183..535623 + 441 WP_126425053.1 hypothetical protein -
EJ378_RS02660 535627..536808 + 1182 WP_126425054.1 alanine racemase -
EJ378_RS02665 537026..537304 + 279 WP_206514593.1 ribbon-helix-helix protein, CopG family Antitoxin
EJ378_RS02670 537308..537658 + 351 WP_126425055.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EJ378_RS02675 537895..538296 + 402 WP_126425056.1 anti-sigma regulatory factor -
EJ378_RS02680 538314..539318 + 1005 WP_126425057.1 PP2C family protein-serine/threonine phosphatase -
EJ378_RS02685 539370..539711 + 342 WP_126425058.1 anti-sigma factor antagonist -
EJ378_RS02690 539702..540193 + 492 WP_126425059.1 anti-sigma B factor RsbW -
EJ378_RS02695 540159..540965 + 807 WP_126425060.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(8-45)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12957.97 Da        Isoelectric Point: 4.8668

>T116193 WP_126425055.1 NZ_CP034541:537308-537658 [Brevibacillus sp. SCSIO 07484]
VIVKRGDVFFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKLYGFDRDSVILLEQI
RTIDKQRLTDKITHLDEEMMERVNESLQISLGLIDF

Download         Length: 351 bp

>T116193 NZ_CP034541:537308-537658 [Brevibacillus sp. SCSIO 07484]
GTGATAGTAAAACGTGGCGATGTTTTTTTTGCGGACCTCTCACCTGTGGTCGGATCCGAACAGGGGGGTGTGCGCCCGGT
TTTGGTGATCCAAAACGATATTGGAAATCGTTTTAGTCCGACTGTCATCGTCGCGGCTATCACGGCACAGATCCAAAAGG
CGAAGTTACCGACGCATGTGGAGATTGATGCCAAATTATACGGGTTTGATCGTGACTCCGTCATCCTCTTGGAGCAGATT
CGCACCATCGACAAACAGCGTCTCACCGATAAAATCACGCATTTGGACGAAGAGATGATGGAGCGCGTCAACGAATCCCT
GCAGATCAGTCTAGGGTTGATAGATTTCTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10690.53 Da        Isoelectric Point: 9.9271

>AT116193 WP_206514593.1 NZ_CP034541:537026-537304 [Brevibacillus sp. SCSIO 07484]
MSKTNTKRIMISLPQHLLQEVDGVVEKEKSNRSELIRQAMSLYLKERKKRFIRETMQKGYMEMAKINLKMASEAFVAEEE
ADLTLDRLVSGV

Download         Length: 279 bp

>AT116193 NZ_CP034541:537026-537304 [Brevibacillus sp. SCSIO 07484]
TTGTCGAAAACCAATACGAAGCGGATCATGATTAGCCTGCCGCAACACTTGTTGCAGGAAGTGGATGGCGTGGTAGAGAA
AGAGAAGTCCAATAGAAGCGAGCTCATTCGTCAGGCTATGAGTCTTTATCTGAAAGAGCGCAAAAAGCGCTTTATCCGGG
AAACAATGCAAAAAGGATATATGGAGATGGCAAAAATCAATTTAAAAATGGCATCCGAGGCGTTTGTCGCCGAGGAGGAG
GCCGACTTGACTTTGGACCGCTTAGTTAGCGGGGTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References