Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 245266..245743 Replicon chromosome
Accession NZ_CP034486
Organism Staphylococcus aureus strain PMB 64-1

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag EJN87_RS01300 Protein ID WP_000052076.1
Coordinates 245266..245454 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag EJN87_RS01305 Protein ID WP_001059690.1
Coordinates 245483..245743 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJN87_RS01275 241029..242468 - 1440 WP_001028144.1 aminoglycoside O-phosphotransferase APH(2'')-Ia -
EJN87_RS01280 242469..242861 - 393 WP_000393259.1 GNAT family N-acetyltransferase -
EJN87_RS01285 242918..244090 - 1173 WP_000195429.1 IS256-like element IS256 family transposase -
EJN87_RS01290 244191..244421 - 231 WP_126133633.1 hypothetical protein -
EJN87_RS01295 244509..245078 - 570 WP_001106654.1 hypothetical protein -
EJN87_RS01300 245266..245454 - 189 WP_000052076.1 hypothetical protein Toxin
EJN87_RS01305 245483..245743 - 261 WP_001059690.1 hypothetical protein Antitoxin
EJN87_RS01310 246083..246286 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
EJN87_RS01315 246283..246519 - 237 WP_000368687.1 hypothetical protein -
EJN87_RS01320 246743..247324 + 582 WP_206435237.1 histidine phosphatase family protein -
EJN87_RS01325 247397..248014 - 618 WP_000255544.1 LysE/ArgO family amino acid transporter -
EJN87_RS01330 248169..248663 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
EJN87_RS01335 249062..249483 - 422 Protein_251 organic hydroperoxide resistance protein -
EJN87_RS01340 249631..250347 + 717 WP_000150012.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-122)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T116181 WP_000052076.1 NZ_CP034486:c245454-245266 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T116181 NZ_CP034486:c245454-245266 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT116181 WP_001059690.1 NZ_CP034486:c245743-245483 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT116181 NZ_CP034486:c245743-245483 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References