116165

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) spoIISABC/-
Location 1348045..1348961 Replicon chromosome
Accession NZ_CP034484
Organism Bacillus subtilis subsp. subtilis NCIB 3610 = ATCC 6051 = DSM 10 strain NCIB 3610

Toxin (Protein)


Gene name spoIISA Uniprot ID O34853
Locus tag EJJ34_RS07150 Protein ID WP_003244695.1
Coordinates 1348215..1348961 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID G4EXD8
Locus tag EJJ34_RS07145 Protein ID WP_003232646.1
Coordinates 1348045..1348215 (-) Length 57 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJJ34_RS07110 (EJJ34_07115) 1344908..1345237 + 330 WP_003232660.1 XkdW family protein -
EJJ34_RS07115 (EJJ34_07120) 1345234..1345398 + 165 WP_003232658.1 XkdX family protein -
EJJ34_RS07120 (EJJ34_07125) 1345442..1346281 + 840 WP_003245597.1 phage-like element PBSX protein XepA -
EJJ34_RS07125 (EJJ34_07130) 1346334..1346603 + 270 WP_003232655.1 hemolysin XhlA family protein -
EJJ34_RS07130 (EJJ34_07135) 1346616..1346879 + 264 WP_003232653.1 phage holin -
EJJ34_RS07135 (EJJ34_07140) 1346892..1347785 + 894 WP_003245230.1 N-acetylmuramoyl-L-alanine amidase -
EJJ34_RS07140 (EJJ34_07145) 1347822..1347959 - 138 WP_003232648.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
EJJ34_RS07145 (EJJ34_07150) 1348045..1348215 - 171 WP_003232646.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
EJJ34_RS07150 (EJJ34_07155) 1348215..1348961 - 747 WP_003244695.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
EJJ34_RS07155 (EJJ34_07160) 1349071..1350072 - 1002 WP_065826289.1 inorganic phosphate transporter -
EJJ34_RS07160 (EJJ34_07165) 1350085..1350702 - 618 WP_003218470.1 DUF47 domain-containing protein -
EJJ34_RS07165 (EJJ34_07170) 1350978..1352294 - 1317 WP_003244819.1 serine/threonine exchanger -
EJJ34_RS07170 (EJJ34_07175) 1352683..1353633 + 951 WP_003245086.1 ring-cleaving dioxygenase -
EJJ34_RS07175 (EJJ34_07180) 1353734..1353880 + 147 WP_003244977.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(42-102)

Antitoxin

(39-78)


Sequences


Toxin        


Download         Length: 249 a.a.        Molecular weight: 36664.99 Da        Isoelectric Point: 5.5500

>T116165 WP_003244695.1 NZ_CP034484:c1348961-1348215 [Bacillus subtilis subsp. subtilis NCIB 3610 = ATCC 6051 = DSM 10]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFF

Download         Length: 747 bp

>T116165 NZ_CP034484:c1348961-1348215 [Bacillus subtilis subsp. subtilis NCIB 3610 = ATCC 6051 = DSM 10]
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Antitoxin


Download         Length: 57 a.a.        Molecular weight: 8407.08 Da        Isoelectric Point: 5.5500

>AT116165 WP_003232646.1 NZ_CP034484:c1348215-1348045 [Bacillus subtilis subsp. subtilis NCIB 3610 = ATCC 6051 = DSM 10]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 171 bp

>AT116165 NZ_CP034484:c1348215-1348045 [Bacillus subtilis subsp. subtilis NCIB 3610 = ATCC 6051 = DSM 10]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
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Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 3O6Q


Antitoxin

Source ID Structure
AlphaFold DB G4EXD8

References