Detailed information of TA system TA116152

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 816755..817454
• Replicon: chromosome
• Accession: NZ_CP034483
• Organism: Rahnella aquatilis strain KM05

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A0H3F674
• Locus tag: EJP80_RS03855
• Protein ID: WP_013574109.1
• Coordinates: 817002..817454 (+)
• Length: 151 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: EJP80_RS03850
• Protein ID: WP_037035260.1
• Coordinates: 816755..817021 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EJP80_RS03820	811762..812097	+	336	WP_013574102.1	DUF2002 family protein	-
EJP80_RS03825	812162..813049	-	888	WP_013574103.1	AraC family transcriptional regulator	-
EJP80_RS03830	813176..813616	-	441	WP_013574104.1	DUF1198 domain-containing protein	-
EJP80_RS03835	813776..814720	-	945	WP_013574105.1	6-phosphofructokinase II	-
EJP80_RS03840	814905..815435	+	531	WP_013574106.1	class IV adenylate cyclase	-
EJP80_RS03845	815484..816476	-	993	WP_013574107.1	tRNA-modifying protein YgfZ	-
EJP80_RS03850	816755..817021	+	267	WP_037035260.1	FAD assembly factor SdhE	Antitoxin
EJP80_RS03855	817002..817454	+	453	WP_013574109.1	protein YgfX	Toxin
EJP80_RS03860	817500..818018	-	519	WP_013574110.1	flavodoxin FldB	-
EJP80_RS03865	818118..819077	+	960	WP_013574111.1	site-specific tyrosine recombinase XerD	-
EJP80_RS03870	819103..819822	+	720	WP_013574112.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
EJP80_RS03875	819829..821562	+	1734	WP_013574113.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-140)

Antitoxin

• Flavinator of succinate dehydrogenase (8-79)

Sequences

Toxin

Protein

• Length: 151 a.a.
• Molecular weight: 17573.93 Da
• Isoelectric Point: 11.8346

>T116152 WP_013574109.1 NZ_CP034483:817002-817454 [Rahnella aquatilis]
VALWRCDLRVSWRSQLISLGCYGAVMLLILLAPWPAGYWPVWMTLLLLVLFECIRSQRRITARTGEMILLEDNRLLWRGH
EWQIKQPVWMISHGVLLSLRREKRKGGLAQAMRSSRQRLWLASDSMSLEEWRRLRQILLSGTPRSPVKPG

Nucleotide

• Length: 453 bp

>T116152 NZ_CP034483:817002-817454 [Rahnella aquatilis]
GTGGCCCTGTGGCGATGTGATCTCAGGGTGTCCTGGCGCAGTCAGCTTATTTCACTGGGATGTTACGGTGCAGTGATGTT
GCTGATTTTGCTGGCACCCTGGCCTGCGGGTTACTGGCCGGTATGGATGACGTTGCTTTTGCTGGTGTTGTTTGAATGCA
TCCGCAGCCAGCGGCGTATTACAGCACGCACAGGTGAAATGATCCTGCTCGAGGATAACCGTCTTTTATGGCGCGGCCAT
GAATGGCAGATTAAACAGCCGGTATGGATGATAAGCCACGGCGTACTGCTCTCGCTTCGTCGCGAAAAACGTAAAGGCGG
GCTGGCGCAGGCGATGCGCAGTTCAAGGCAGCGGTTATGGCTGGCGTCGGACAGCATGAGTCTGGAAGAGTGGCGGCGGT
TGCGACAGATATTGCTCAGTGGCACTCCGCGTAGCCCGGTAAAACCGGGCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10464.97 Da
• Isoelectric Point: 5.1236

>AT116152 WP_037035260.1 NZ_CP034483:816755-817021 [Rahnella aquatilis]
MDINNRSRVHWACRRGMRELDISIMPFFEYEYDSLSETDKEVFVRLLTCDDPDLFNWLMNHGEPKDTELQRMVALIQTRN
KARGPVAM

Nucleotide

• Length: 267 bp

>AT116152 NZ_CP034483:816755-817021 [Rahnella aquatilis]
CTGGATATTAATAATCGTTCCCGCGTTCACTGGGCCTGCCGTCGTGGCATGCGCGAGCTGGATATCTCCATCATGCCGTT
CTTCGAATATGAATATGATTCGCTGAGCGAGACCGATAAAGAAGTATTTGTCCGCTTGCTGACCTGTGATGATCCGGATC
TGTTCAACTGGCTGATGAATCACGGCGAACCGAAAGACACCGAATTGCAGCGTATGGTCGCCCTTATTCAGACTCGAAAC
AAAGCCCGTGGCCCTGTGGCGATGTGA

Structures

Toxin

• AlphaFold DB: A0A0H3F674