Detailed information of TA system TA116149

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 4199080..4199907
• Replicon: chromosome
• Accession: NZ_CP034482
• Organism: Rahnella aquatilis strain KM12

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: EJP81_RS19315
• Protein ID: WP_126125193.1
• Coordinates: 4199080..4199463 (-)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: EJP81_RS19320
• Protein ID: WP_126125194.1
• Coordinates: 4199539..4199907 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EJP81_RS19300	4195143..4196006	-	864	Protein_3768	DUF4942 domain-containing protein	-
EJP81_RS19305	4196145..4197371	-	1227	WP_126125191.1	O-antigen ligase family protein	-
EJP81_RS19310	4197368..4198543	-	1176	WP_126125192.1	putative lipopolysaccharide heptosyltransferase III	-
EJP81_RS19315	4199080..4199463	-	384	WP_126125193.1	TA system toxin CbtA family protein	Toxin
EJP81_RS19320	4199539..4199907	-	369	WP_126125194.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
EJP81_RS19325	4199963..4200169	-	207	WP_126125195.1	hypothetical protein	-
EJP81_RS19330	4200179..4200628	-	450	WP_126125196.1	DNA repair protein RadC	-
EJP81_RS19335	4200721..4201542	-	822	WP_126125197.1	DUF945 domain-containing protein	-
EJP81_RS19340	4201659..4202777	-	1119	WP_126125198.1	hypothetical protein	-
EJP81_RS19345	4203215..4204099	-	885	WP_126125199.1	50S ribosome-binding GTPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4182832..4249400	66568

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (13-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14198.12 Da
• Isoelectric Point: 8.0195

>T116149 WP_126125193.1 NZ_CP034482:c4199463-4199080 [Rahnella aquatilis]
MKTSISAAPSAVPVSSCPSHVAVWQQLLTYLFDRHYGLTLNDTPFHYESVIEEYIDAGISLKDAVNFVAERYGLLRIDRS
SSAYAEQPPFISYVNILQARRATGLMPQGGYKEIRVLTQGKRTTEGR

Nucleotide

• Length: 384 bp

>T116149 NZ_CP034482:c4199463-4199080 [Rahnella aquatilis]
ATGAAAACCTCAATCTCTGCGGCACCGTCAGCGGTGCCAGTATCGTCATGCCCGTCGCACGTGGCCGTTTGGCAGCAGCT
GCTGACGTATCTGTTCGACCGCCATTACGGCCTGACGCTCAACGACACGCCGTTCCACTATGAATCCGTGATAGAGGAAT
ATATCGATGCCGGTATTTCTTTGAAAGACGCGGTGAACTTTGTGGCCGAACGATATGGCCTTCTGCGCATTGACCGCAGC
AGCAGTGCTTACGCTGAACAGCCGCCGTTCATTTCCTACGTCAACATTCTTCAGGCGCGTCGGGCCACTGGCCTGATGCC
ACAAGGAGGATATAAAGAGATAAGGGTTCTCACCCAGGGGAAAAGGACCACCGAAGGCAGGTGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13351.20 Da
• Isoelectric Point: 6.0553

>AT116149 WP_126125194.1 NZ_CP034482:c4199907-4199539 [Rahnella aquatilis]
MTLPLPPATQPTVVPAGPQWGLIRDISPCFGARLVQEGNRLHYLADRAGFCGEFTADDALRLDQAFPLILKQLEQTLLSG
GLDPRRQQRVTLHHNGLTCDADTLGSHGYVYLSIYPTPPEAT

Nucleotide

• Length: 369 bp

>AT116149 NZ_CP034482:c4199907-4199539 [Rahnella aquatilis]
ATGACTCTCCCACTCCCCCCGGCCACCCAGCCGACAGTCGTCCCTGCGGGTCCGCAATGGGGGCTGATCCGCGATATATC
TCCGTGCTTCGGTGCCCGCCTGGTGCAGGAAGGCAACCGTCTGCATTATCTGGCCGACCGGGCAGGCTTCTGTGGTGAAT
TTACTGCCGACGACGCCCTGCGGCTCGATCAGGCATTTCCACTAATACTGAAACAATTGGAGCAGACGCTGTTGTCCGGT
GGGCTTGATCCGCGCCGCCAGCAACGCGTTACACTCCATCACAACGGCCTGACCTGCGACGCTGACACCCTCGGGTCGCA
CGGCTATGTGTACCTGTCCATTTATCCAACACCACCTGAGGCAACATGA