Detailed information of TA system TA116138

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 1468973..1469889
• Replicon: chromosome
• Accession: NZ_CP034482
• Organism: Rahnella aquatilis strain KM12

Toxin (Protein)

• Gene name: -
• Uniprot ID: H8NRM1
• Locus tag: EJP81_RS06815
• Protein ID: WP_013574722.1
• Coordinates: 1468973..1469431 (-)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: H2IQN3
• Locus tag: EJP81_RS06820
• Protein ID: WP_013574723.1
• Coordinates: 1469428..1469889 (-)
• Length: 154 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EJP81_RS06790	1464598..1466283	+	1686	WP_013574717.1	choline dehydrogenase	-
EJP81_RS06795	1466374..1466832	+	459	WP_013574718.1	GNAT family N-acetyltransferase	-
EJP81_RS06800	1467020..1467952	-	933	WP_041673052.1	LysR family transcriptional regulator	-
EJP81_RS06805	1468055..1468489	+	435	WP_126125296.1	DMT family transporter	-
EJP81_RS06810	1468493..1468945	+	453	WP_013574721.1	DMT family transporter	-
EJP81_RS06815	1468973..1469431	-	459	WP_013574722.1	RES family NAD+ phosphorylase	Toxin
EJP81_RS06820	1469428..1469889	-	462	WP_013574723.1	DUF2384 domain-containing protein	Antitoxin
EJP81_RS06825	1470240..1471127	+	888	WP_013574724.1	nucleoside-specific channel-forming protein Tsx	-
EJP81_RS06830	1471314..1472909	+	1596	WP_013574725.1	ABC-F family ATPase	-
EJP81_RS06835	1473103..1473864	-	762	WP_013574726.1	molybdopterin-synthase adenylyltransferase MoeB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (2-136)

Antitoxin

• Antitoxin Xre-like, helix-turn-helix domain (34-95)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 16974.55 Da
• Isoelectric Point: 4.7091

>T116138 WP_013574722.1 NZ_CP034482:c1469431-1468973 [Rahnella aquatilis]
MKLFRIVQTRHLATAWSGAGAQLYGGRWNPPGRPVVYVTTSISLAILEILVHLQNSMLMRSYTLLSIEVPEELLDTLEVS
ELAADWRSASVPDSTQRQGDVWLAEGEYVGLKVPSVIVPSEYNVLLNPLHPAFADLLSSVEREPMMFDPRLQ

Nucleotide

• Length: 459 bp

>T116138 NZ_CP034482:c1469431-1468973 [Rahnella aquatilis]
TTGAAGCTGTTTCGTATCGTGCAGACCCGCCATCTGGCGACAGCCTGGTCGGGAGCCGGCGCGCAACTTTATGGCGGTCG
CTGGAATCCGCCAGGCAGGCCGGTCGTCTATGTCACCACCAGCATCTCACTGGCTATCCTGGAAATTCTGGTGCATTTGC
AAAACAGCATGTTGATGCGTTCCTATACCTTGCTGAGTATTGAGGTGCCAGAGGAACTGCTGGATACGCTGGAAGTTTCA
GAGCTTGCCGCCGACTGGCGAAGCGCATCAGTGCCTGACAGCACTCAACGTCAGGGTGACGTCTGGCTTGCAGAAGGTGA
ATATGTCGGGCTGAAAGTGCCGTCAGTGATTGTGCCGTCGGAATACAACGTATTACTTAATCCGCTACACCCGGCTTTTG
CCGATTTACTGAGTTCAGTAGAACGCGAGCCCATGATGTTTGACCCGCGCCTGCAATAA

Antitoxin

Protein

• Length: 154 a.a.
• Molecular weight: 16505.80 Da
• Isoelectric Point: 7.0196

>AT116138 WP_013574723.1 NZ_CP034482:c1469889-1469428 [Rahnella aquatilis]
MNSKITGLSSSSVQDSATPLWQSAGLPASSGISLINAIQKGFPVDSISRLNTELGWPKMVLLEIMGINERNYARRKAGNG
LLKSEESERVARLVRIVDAATDLFEGDRVSALEWFTRPAPALDGSRPLELLSSEAGAVEVSRLIGRLQHGVFS

Nucleotide

• Length: 462 bp

>AT116138 NZ_CP034482:c1469889-1469428 [Rahnella aquatilis]
ATGAATTCAAAAATTACCGGGCTGTCTTCCAGCTCTGTGCAAGATTCTGCAACGCCGCTTTGGCAATCTGCGGGCCTTCC
CGCAAGCAGCGGAATCAGTTTGATAAATGCCATACAAAAGGGATTTCCGGTTGATAGTATCAGCCGTCTTAATACTGAGC
TGGGATGGCCAAAAATGGTGTTACTGGAAATCATGGGCATTAACGAACGCAACTATGCCCGGCGTAAAGCCGGGAACGGA
TTGCTAAAAAGTGAAGAGAGTGAACGTGTGGCGCGACTGGTTCGCATCGTGGATGCCGCAACTGATTTGTTCGAAGGGGA
TCGTGTCTCGGCGCTCGAATGGTTCACCCGCCCTGCTCCGGCACTGGATGGTTCACGTCCGCTGGAACTGCTGTCTTCTG
AAGCGGGTGCTGTGGAAGTCAGCCGCCTGATTGGTCGTCTCCAGCACGGTGTTTTCAGTTGA

Structures

Toxin

• AlphaFold DB: H8NRM1

Antitoxin

• AlphaFold DB: A0A0H3F7Y1