Detailed information of TA system TA116137

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 785630..786329
• Replicon: chromosome
• Accession: NZ_CP034482
• Organism: Rahnella aquatilis strain KM12

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A0H3F674
• Locus tag: EJP81_RS03690
• Protein ID: WP_013574109.1
• Coordinates: 785877..786329 (+)
• Length: 151 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: EJP81_RS03685
• Protein ID: WP_037035260.1
• Coordinates: 785630..785896 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EJP81_RS03655	780638..780973	+	336	WP_013574102.1	DUF2002 family protein	-
EJP81_RS03660	781038..781925	-	888	WP_013574103.1	AraC family transcriptional regulator	-
EJP81_RS03665	782052..782492	-	441	WP_013574104.1	DUF1198 domain-containing protein	-
EJP81_RS03670	782652..783596	-	945	WP_112152335.1	6-phosphofructokinase II	-
EJP81_RS03675	783780..784310	+	531	WP_013574106.1	class IV adenylate cyclase	-
EJP81_RS03680	784359..785351	-	993	WP_112152336.1	tRNA-modifying protein YgfZ	-
EJP81_RS03685	785630..785896	+	267	WP_037035260.1	FAD assembly factor SdhE	Antitoxin
EJP81_RS03690	785877..786329	+	453	WP_013574109.1	protein YgfX	Toxin
EJP81_RS03695	786375..786893	-	519	WP_013574110.1	flavodoxin FldB	-
EJP81_RS03700	786993..787952	+	960	WP_013574111.1	site-specific tyrosine recombinase XerD	-
EJP81_RS03705	787978..788697	+	720	WP_013574112.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
EJP81_RS03710	788704..790437	+	1734	WP_013574113.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-140)

Antitoxin

• Flavinator of succinate dehydrogenase (8-79)

Sequences

Toxin

Protein

• Length: 151 a.a.
• Molecular weight: 17573.93 Da
• Isoelectric Point: 11.8346

>T116137 WP_013574109.1 NZ_CP034482:785877-786329 [Rahnella aquatilis]
VALWRCDLRVSWRSQLISLGCYGAVMLLILLAPWPAGYWPVWMTLLLLVLFECIRSQRRITARTGEMILLEDNRLLWRGH
EWQIKQPVWMISHGVLLSLRREKRKGGLAQAMRSSRQRLWLASDSMSLEEWRRLRQILLSGTPRSPVKPG

Nucleotide

• Length: 453 bp

>T116137 NZ_CP034482:785877-786329 [Rahnella aquatilis]
GTGGCCCTGTGGCGATGTGATCTCAGGGTGTCCTGGCGCAGTCAGCTTATTTCACTGGGATGTTACGGTGCAGTGATGTT
GCTGATTTTGCTGGCACCCTGGCCTGCGGGTTACTGGCCGGTATGGATGACGTTGCTTTTGCTGGTGTTGTTTGAATGCA
TCCGCAGCCAGCGGCGTATTACAGCACGCACAGGTGAAATGATCCTGCTCGAGGATAACCGTCTTTTATGGCGCGGCCAT
GAATGGCAGATTAAACAGCCGGTATGGATGATAAGCCACGGCGTACTGCTCTCGCTTCGTCGCGAAAAACGTAAAGGCGG
GCTGGCGCAGGCGATGCGCAGTTCAAGGCAGCGGTTATGGCTGGCGTCGGACAGCATGAGTCTGGAAGAGTGGCGGCGGT
TGCGACAGATATTGCTCAGTGGCACTCCGCGTAGCCCGGTAAAACCGGGCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10464.97 Da
• Isoelectric Point: 5.1236

>AT116137 WP_037035260.1 NZ_CP034482:785630-785896 [Rahnella aquatilis]
MDINNRSRVHWACRRGMRELDISIMPFFEYEYDSLSETDKEVFVRLLTCDDPDLFNWLMNHGEPKDTELQRMVALIQTRN
KARGPVAM

Nucleotide

• Length: 267 bp

>AT116137 NZ_CP034482:785630-785896 [Rahnella aquatilis]
CTGGATATTAATAATCGTTCCCGCGTTCACTGGGCCTGCCGTCGTGGCATGCGCGAGCTGGATATCTCCATCATGCCGTT
CTTCGAATATGAATATGATTCGCTGAGCGAGACCGATAAAGAAGTATTTGTCCGCTTGCTGACCTGTGATGATCCGGATC
TGTTCAACTGGCTGATGAATCACGGCGAACCGAAAGACACCGAATTGCAGCGTATGGTCGCCCTTATTCAGACTCGAAAC
AAAGCCCGTGGCCCTGTGGCGATGTGA

Structures

Toxin

• AlphaFold DB: A0A0H3F674