Detailed information of TA system TA116115

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 120650..121185
• Replicon: plasmid pCFSAN047154_2
• Accession: NZ_CP034476
• Organism: Pantoea agglomerans strain CFSAN047154

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: D1629_RS22605
• Protein ID: WP_129063431.1
• Coordinates: 120650..120937 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A7X2SUR0
• Locus tag: D1629_RS22610
• Protein ID: WP_033774093.1
• Coordinates: 120934..121185 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1629_RS22580	115857..117452	-	1596	WP_129063430.1	GNAT family N-acetyltransferase	-
D1629_RS22585	118010..118635	-	626	Protein_100	transposase	-
D1629_RS22590	118669..118899	-	231	Protein_101	helix-turn-helix domain-containing protein	-
D1629_RS22595	119158..119976	+	819	WP_089415112.1	DUF4225 domain-containing protein	-
D1629_RS22600	119973..120287	-	315	WP_033759977.1	hypothetical protein	-
D1629_RS22605	120650..120937	-	288	WP_129063431.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D1629_RS22610	120934..121185	-	252	WP_033774093.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
D1629_RS22615	121486..122619	-	1134	WP_033774091.1	glutathione-independent formaldehyde dehydrogenase	-
D1629_RS22620	122989..123939	-	951	WP_010671919.1	sulfonate ABC transporter substrate-binding protein	-
D1629_RS22625	124035..125924	-	1890	WP_033774090.1	sigma-54-dependent Fis family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Mobilizable plasmid	-	pilW	1..211326	211326

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11187.11 Da
• Isoelectric Point: 10.3856

>T116115 WP_129063431.1 NZ_CP034476:c120937-120650 [Pantoea agglomerans]
VSYTVKFREEAFKEWQKLDKSLQQQFAKKLKKCCDNPHIPSARLRGIKDCYKIKLRASGFRLVYQVIDDQLVIAVVALGK
RERSDVYHLASERMR

Nucleotide

• Length: 288 bp

>T116115 NZ_CP034476:c120937-120650 [Pantoea agglomerans]
GTGAGTTATACCGTCAAATTCAGGGAAGAGGCATTTAAAGAATGGCAGAAGCTGGACAAATCTCTCCAGCAGCAGTTTGC
CAAAAAACTGAAGAAATGTTGTGACAATCCCCATATTCCTTCTGCCAGACTACGTGGGATTAAAGACTGCTATAAAATCA
AACTCAGAGCGTCCGGGTTTCGCCTGGTTTATCAGGTAATAGACGACCAGCTGGTGATTGCCGTTGTTGCTCTGGGTAAA
CGCGAGCGCAGCGATGTTTATCATCTTGCCAGTGAAAGGATGCGGTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9138.46 Da
• Isoelectric Point: 3.9507

>AT116115 WP_033774093.1 NZ_CP034476:c121185-120934 [Pantoea agglomerans]
MPNMILSDISASVSELKKNPMATVNAGDGYPVAILNRNQPAFYCVPAELYEQMLDALDDQELVKLVSERSGQRLLDVDLD
ALL

Nucleotide

• Length: 252 bp

>AT116115 NZ_CP034476:c121185-120934 [Pantoea agglomerans]
ATGCCAAACATGATTTTAAGCGATATCAGTGCCAGCGTAAGCGAACTGAAAAAAAATCCAATGGCTACTGTTAATGCCGG
GGACGGTTATCCGGTCGCCATTCTCAACCGCAACCAGCCTGCATTCTATTGCGTGCCAGCTGAGCTTTATGAGCAGATGC
TTGATGCCCTTGACGATCAGGAACTGGTTAAGCTGGTCAGTGAGCGCAGCGGCCAGCGTCTGCTTGATGTCGATTTGGAT
GCGCTTTTGTGA

Structures

Antitoxin

• AlphaFold DB: A0A7X2SUR0