Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1674917..1675580 Replicon chromosome
Accession NZ_CP034474
Organism Pantoea agglomerans strain CFSAN047154

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag D1629_RS07910 Protein ID WP_071998040.1
Coordinates 1674917..1675231 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag D1629_RS07915 Protein ID WP_033757561.1
Coordinates 1675224..1675580 (+) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1629_RS07890 1670339..1671736 + 1398 WP_010245332.1 class II fumarate hydratase -
D1629_RS07895 1671780..1672709 - 930 WP_033757557.1 DNA replication terminus site-binding protein -
D1629_RS07900 1672912..1674096 + 1185 WP_033787932.1 MFS transporter -
D1629_RS07905 1674304..1674798 + 495 WP_010245324.1 Rrf2 family transcriptional regulator -
D1629_RS07910 1674917..1675231 + 315 WP_071998040.1 type II toxin-antitoxin system HicA family toxin Toxin
D1629_RS07915 1675224..1675580 + 357 WP_033757561.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
D1629_RS07920 1675666..1678818 - 3153 WP_031593601.1 multidrug efflux RND transporter permease subunit OqxB -
D1629_RS07925 1678831..1679985 - 1155 WP_022625698.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(41-90)

Antitoxin

Uncharacterised protein family HicB

(59-111)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11931.69 Da        Isoelectric Point: 9.9846

>T116109 WP_071998040.1 NZ_CP034474:1674917-1675231 [Pantoea agglomerans]
MTSLDEVAEVRMNTVVRELRKKHRETLEQVFQMPPPSGLKWQAVESLIRALGGEIKEGSGSRVRFLLRGRIARFHRPHPS
PDTDRGAVINLREWLESIGVDPYE

Download         Length: 315 bp

>T116109 NZ_CP034474:1674917-1675231 [Pantoea agglomerans]
ATGACTTCACTGGATGAAGTCGCGGAGGTCAGGATGAACACCGTTGTCAGGGAGTTACGGAAAAAACATCGTGAAACGTT
GGAGCAGGTTTTTCAAATGCCGCCGCCGTCCGGACTGAAATGGCAGGCAGTTGAGTCATTAATCAGGGCTCTGGGTGGTG
AGATTAAAGAAGGCAGTGGTTCACGGGTGCGATTTCTTCTCAGAGGAAGAATAGCGCGTTTTCACCGGCCGCATCCTTCG
CCAGACACCGACAGAGGGGCTGTTATTAATCTGCGTGAATGGCTGGAAAGTATTGGAGTCGATCCCTATGAATAA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 13250.86 Da        Isoelectric Point: 4.8896

>AT116109 WP_033757561.1 NZ_CP034474:1675224-1675580 [Pantoea agglomerans]
MNNRSNSSITVAGQPAVITYVPELNMFRGRFTGLSGYCDFVSDSVQGLYKEGEISLREYLEDCAASGINPYAEQEKIKTF
TLRYPESLGERLSQAAAQNETSLNAFIIETLNERLKRR

Download         Length: 357 bp

>AT116109 NZ_CP034474:1675224-1675580 [Pantoea agglomerans]
ATGAATAATCGTTCAAATTCATCAATCACCGTCGCTGGTCAACCCGCTGTGATCACCTATGTTCCTGAACTCAACATGTT
CCGTGGGCGTTTTACTGGCCTGTCAGGCTACTGTGATTTTGTCTCTGACAGCGTACAGGGGCTGTACAAAGAGGGCGAGA
TTTCGTTGCGCGAATACCTGGAAGATTGTGCAGCCTCCGGCATTAATCCCTATGCTGAGCAGGAAAAAATTAAGACCTTT
ACGCTGCGCTATCCTGAATCGCTGGGAGAGCGCCTGTCTCAGGCTGCCGCGCAAAATGAAACCTCGCTGAATGCGTTTAT
CATTGAAACGCTGAATGAAAGATTGAAGCGGCGCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References