Detailed information of TA system TA116109

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 1674917..1675580
• Replicon: chromosome
• Accession: NZ_CP034474
• Organism: Pantoea agglomerans strain CFSAN047154

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: D1629_RS07910
• Protein ID: WP_071998040.1
• Coordinates: 1674917..1675231 (+)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: D1629_RS07915
• Protein ID: WP_033757561.1
• Coordinates: 1675224..1675580 (+)
• Length: 119 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1629_RS07890	1670339..1671736	+	1398	WP_010245332.1	class II fumarate hydratase	-
D1629_RS07895	1671780..1672709	-	930	WP_033757557.1	DNA replication terminus site-binding protein	-
D1629_RS07900	1672912..1674096	+	1185	WP_033787932.1	MFS transporter	-
D1629_RS07905	1674304..1674798	+	495	WP_010245324.1	Rrf2 family transcriptional regulator	-
D1629_RS07910	1674917..1675231	+	315	WP_071998040.1	type II toxin-antitoxin system HicA family toxin	Toxin
D1629_RS07915	1675224..1675580	+	357	WP_033757561.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
D1629_RS07920	1675666..1678818	-	3153	WP_031593601.1	multidrug efflux RND transporter permease subunit OqxB	-
D1629_RS07925	1678831..1679985	-	1155	WP_022625698.1	efflux RND transporter periplasmic adaptor subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (41-90)

Antitoxin

• Uncharacterised protein family HicB (59-111)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 11931.69 Da
• Isoelectric Point: 9.9846

>T116109 WP_071998040.1 NZ_CP034474:1674917-1675231 [Pantoea agglomerans]
MTSLDEVAEVRMNTVVRELRKKHRETLEQVFQMPPPSGLKWQAVESLIRALGGEIKEGSGSRVRFLLRGRIARFHRPHPS
PDTDRGAVINLREWLESIGVDPYE

Nucleotide

• Length: 315 bp

>T116109 NZ_CP034474:1674917-1675231 [Pantoea agglomerans]
ATGACTTCACTGGATGAAGTCGCGGAGGTCAGGATGAACACCGTTGTCAGGGAGTTACGGAAAAAACATCGTGAAACGTT
GGAGCAGGTTTTTCAAATGCCGCCGCCGTCCGGACTGAAATGGCAGGCAGTTGAGTCATTAATCAGGGCTCTGGGTGGTG
AGATTAAAGAAGGCAGTGGTTCACGGGTGCGATTTCTTCTCAGAGGAAGAATAGCGCGTTTTCACCGGCCGCATCCTTCG
CCAGACACCGACAGAGGGGCTGTTATTAATCTGCGTGAATGGCTGGAAAGTATTGGAGTCGATCCCTATGAATAA

Antitoxin

Protein

• Length: 119 a.a.
• Molecular weight: 13250.86 Da
• Isoelectric Point: 4.8896

>AT116109 WP_033757561.1 NZ_CP034474:1675224-1675580 [Pantoea agglomerans]
MNNRSNSSITVAGQPAVITYVPELNMFRGRFTGLSGYCDFVSDSVQGLYKEGEISLREYLEDCAASGINPYAEQEKIKTF
TLRYPESLGERLSQAAAQNETSLNAFIIETLNERLKRR

Nucleotide

• Length: 357 bp

>AT116109 NZ_CP034474:1675224-1675580 [Pantoea agglomerans]
ATGAATAATCGTTCAAATTCATCAATCACCGTCGCTGGTCAACCCGCTGTGATCACCTATGTTCCTGAACTCAACATGTT
CCGTGGGCGTTTTACTGGCCTGTCAGGCTACTGTGATTTTGTCTCTGACAGCGTACAGGGGCTGTACAAAGAGGGCGAGA
TTTCGTTGCGCGAATACCTGGAAGATTGTGCAGCCTCCGGCATTAATCCCTATGCTGAGCAGGAAAAAATTAAGACCTTT
ACGCTGCGCTATCCTGAATCGCTGGGAGAGCGCCTGTCTCAGGCTGCCGCGCAAAATGAAACCTCGCTGAATGCGTTTAT
CATTGAAACGCTGAATGAAAGATTGAAGCGGCGCTAG