Detailed information of TA system TA116107

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 534034..534665
• Replicon: chromosome
• Accession: NZ_CP034474
• Organism: Pantoea agglomerans strain CFSAN047154

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: D1629_RS02395
• Protein ID: WP_072008743.1
• Coordinates: 534034..534213 (+)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A8X8DTB6
• Locus tag: D1629_RS02400
• Protein ID: WP_010253955.1
• Coordinates: 534240..534665 (+)
• Length: 142 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1629_RS02385	530365..532266	+	1902	WP_039386527.1	pyruvate dehydrogenase complex dihydrolipoyllysine-residue acetyltransferase	-
D1629_RS02390	532427..533851	+	1425	WP_010253950.1	dihydrolipoyl dehydrogenase	-
D1629_RS02395	534034..534213	+	180	WP_072008743.1	type II toxin-antitoxin system HicA family toxin	Toxin
D1629_RS02400	534240..534665	+	426	WP_010253955.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
D1629_RS02405	534747..534887	+	141	WP_033770968.1	CRISPR-associated protein Cas1	-
D1629_RS02410	535072..536001	+	930	WP_033770970.1	Rpn family recombination-promoting nuclease/putative transposase	-
D1629_RS02415	536430..537329	-	900	WP_033770972.1	LysR family transcriptional regulator	-
D1629_RS02420	537435..537944	+	510	WP_010253965.1	phenolic acid decarboxylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-58)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6635.76 Da
• Isoelectric Point: 11.3688

>T116107 WP_072008743.1 NZ_CP034474:534034-534213 [Pantoea agglomerans]
MDRSTLISEMKADGWVLTRINGSHHHFTHPTKPGLVTVPHPKKDLPIGTVKSIRKQARI

Nucleotide

• Length: 180 bp

>T116107 NZ_CP034474:534034-534213 [Pantoea agglomerans]
ATGGATCGCAGCACGTTAATTTCCGAAATGAAGGCTGATGGCTGGGTTCTGACAAGGATAAACGGTAGCCATCACCATTT
CACACATCCGACAAAACCGGGGCTGGTTACAGTACCCCATCCTAAAAAAGACTTACCGATCGGTACGGTAAAGAGCATCA
GGAAACAAGCGAGAATTTAA

Antitoxin

Protein

• Length: 142 a.a.
• Molecular weight: 15422.60 Da
• Isoelectric Point: 4.7662

>AT116107 WP_010253955.1 NZ_CP034474:534240-534665 [Pantoea agglomerans]
MFYPIAIEAGDHEHAYGVIVPDLPGCFSAGDTLDEAIKNAKEAITGHIELCVELGHEIPAVSTIETLATNPDYQGYIWAL
VDVDVIRLLGGSEKINVTLPRSLIDRIDRCVASHPEYKSRSGFLAQVALERITAPINRPQK

Nucleotide

• Length: 426 bp

>AT116107 NZ_CP034474:534240-534665 [Pantoea agglomerans]
ATGTTTTATCCAATCGCGATTGAAGCGGGTGATCACGAACACGCATACGGCGTAATCGTTCCCGATTTACCAGGGTGTTT
CTCTGCCGGGGATACTCTTGATGAAGCCATTAAAAACGCCAAAGAGGCTATCACAGGGCATATCGAATTATGTGTAGAGC
TCGGTCATGAGATCCCTGCCGTGTCCACCATTGAGACTCTGGCCACGAATCCTGACTATCAGGGTTATATCTGGGCATTG
GTTGATGTAGATGTCATTCGTTTGCTGGGCGGCTCTGAAAAAATCAATGTCACTTTACCCAGGTCGTTAATTGATCGGAT
TGATCGTTGTGTGGCTTCACACCCGGAATACAAAAGTCGCTCGGGCTTTCTGGCTCAGGTAGCGCTTGAGCGTATTACTG
CTCCGATTAACAGGCCTCAAAAGTAA