Detailed information of TA system TA116105

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 74653..75188
• Replicon: plasmid pCFSAN047153_2
• Accession: NZ_CP034471
• Organism: Pantoea agglomerans strain CFSAN047153

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: D1628_RS22400
• Protein ID: WP_129063431.1
• Coordinates: 74901..75188 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A7X2SUR0
• Locus tag: D1628_RS22395
• Protein ID: WP_033774093.1
• Coordinates: 74653..74904 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1628_RS22380	69914..71803	+	1890	WP_033774090.1	sigma-54-dependent Fis family transcriptional regulator	-
D1628_RS22385	71899..72849	+	951	WP_010671919.1	sulfonate ABC transporter substrate-binding protein	-
D1628_RS22390	73219..74352	+	1134	WP_033774091.1	glutathione-independent formaldehyde dehydrogenase	-
D1628_RS22395	74653..74904	+	252	WP_033774093.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
D1628_RS22400	74901..75188	+	288	WP_129063431.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D1628_RS22405	75551..75865	+	315	WP_033759977.1	hypothetical protein	-
D1628_RS22410	75862..76680	-	819	WP_089415112.1	DUF4225 domain-containing protein	-
D1628_RS22415	76939..77169	+	231	Protein_65	helix-turn-helix domain-containing protein	-
D1628_RS22420	77203..77828	+	626	Protein_66	transposase	-
D1628_RS22425	78386..79981	+	1596	WP_129063430.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Mobilizable plasmid	-	pilW	1..211326	211326

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11187.11 Da
• Isoelectric Point: 10.3856

>T116105 WP_129063431.1 NZ_CP034471:74901-75188 [Pantoea agglomerans]
VSYTVKFREEAFKEWQKLDKSLQQQFAKKLKKCCDNPHIPSARLRGIKDCYKIKLRASGFRLVYQVIDDQLVIAVVALGK
RERSDVYHLASERMR

Nucleotide

• Length: 288 bp

>T116105 NZ_CP034471:74901-75188 [Pantoea agglomerans]
GTGAGTTATACCGTCAAATTCAGGGAAGAGGCATTTAAAGAATGGCAGAAGCTGGACAAATCTCTCCAGCAGCAGTTTGC
CAAAAAACTGAAGAAATGTTGTGACAATCCCCATATTCCTTCTGCCAGACTACGTGGGATTAAAGACTGCTATAAAATCA
AACTCAGAGCGTCCGGGTTTCGCCTGGTTTATCAGGTAATAGACGACCAGCTGGTGATTGCCGTTGTTGCTCTGGGTAAA
CGCGAGCGCAGCGATGTTTATCATCTTGCCAGTGAAAGGATGCGGTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9138.46 Da
• Isoelectric Point: 3.9507

>AT116105 WP_033774093.1 NZ_CP034471:74653-74904 [Pantoea agglomerans]
MPNMILSDISASVSELKKNPMATVNAGDGYPVAILNRNQPAFYCVPAELYEQMLDALDDQELVKLVSERSGQRLLDVDLD
ALL

Nucleotide

• Length: 252 bp

>AT116105 NZ_CP034471:74653-74904 [Pantoea agglomerans]
ATGCCAAACATGATTTTAAGCGATATCAGTGCCAGCGTAAGCGAACTGAAAAAAAATCCAATGGCTACTGTTAATGCCGG
GGACGGTTATCCGGTCGCCATTCTCAACCGCAACCAGCCTGCATTCTATTGCGTGCCAGCTGAGCTTTATGAGCAGATGC
TTGATGCCCTTGACGATCAGGAACTGGTTAAGCTGGTCAGTGAGCGCAGCGGCCAGCGTCTGCTTGATGTCGATTTGGAT
GCGCTTTTGTGA

Structures

Antitoxin

• AlphaFold DB: A0A7X2SUR0