Detailed information of TA system TA116101

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 195001..195911
• Replicon: plasmid pCFSAN047153_1
• Accession: NZ_CP034470
• Organism: Pantoea agglomerans strain CFSAN047153

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: D1628_RS20075
• Protein ID: WP_129063403.1
• Coordinates: 195001..195471 (-)
• Length: 157 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: D1628_RS20080
• Protein ID: WP_129063402.1
• Coordinates: 195468..195911 (-)
• Length: 148 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1628_RS20065	191080..193809	+	2730	WP_129063404.1	cation-transporting P-type ATPase	-
D1628_RS20070	193798..194829	-	1032	WP_010670602.1	AI-2E family transporter	-
D1628_RS20075	195001..195471	-	471	WP_129063403.1	RES family NAD+ phosphorylase	Toxin
D1628_RS20080	195468..195911	-	444	WP_129063402.1	DUF2384 domain-containing protein	Antitoxin
D1628_RS20085	196295..196444	+	150	Protein_204	aldo/keto reductase	-
D1628_RS20090	196470..197459	+	990	WP_033773648.1	aldo/keto reductase	-
D1628_RS20095	197494..197902	-	409	Protein_206	transcriptional regulator	-
D1628_RS20100	198125..198739	+	615	WP_033773649.1	TetR/AcrR family transcriptional regulator	-
D1628_RS20105	198790..199689	+	900	WP_033773651.1	alpha/beta hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	iroN	1..613013	613013

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-148)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (94-144)

Sequences

Toxin

Protein

• Length: 157 a.a.
• Molecular weight: 17513.95 Da
• Isoelectric Point: 4.6346

>T116101 WP_129063403.1 NZ_CP034470:c195471-195001 [Pantoea agglomerans]
MILYRLTKTKYLSTAWTGFGAKEAGGRWNSIGISMVYVSETASLTLLETLVHLHSAHILDAFTLLRIDVPDALIQTADIT
ELPANWADEDAPAELADYGDAWCFACDAVALRVPSALSPVEYNYLLNPEHPEFFRIVQQAEAIPFRFDRRLKPDRT

Nucleotide

• Length: 471 bp

>T116101 NZ_CP034470:c195471-195001 [Pantoea agglomerans]
TTGATTCTCTACAGGCTGACTAAGACAAAGTATCTTTCGACAGCCTGGACGGGATTTGGCGCAAAAGAGGCGGGCGGCCG
CTGGAACAGCATCGGCATCTCCATGGTTTATGTTTCTGAAACAGCATCACTGACTTTGCTGGAAACACTGGTCCATCTGC
ACTCAGCACACATCCTGGACGCATTCACACTTCTGCGCATCGATGTTCCCGATGCGTTGATTCAGACCGCTGATATCACT
GAGTTGCCTGCAAACTGGGCCGATGAAGACGCACCGGCAGAACTGGCTGACTATGGAGACGCCTGGTGCTTTGCCTGCGA
TGCGGTTGCGTTGCGTGTTCCCAGTGCCCTCTCCCCTGTAGAATATAACTATCTGTTAAATCCTGAACATCCCGAGTTCT
TCCGGATAGTTCAACAGGCTGAGGCCATTCCGTTCCGGTTTGATCGTCGGCTGAAACCGGATCGTACATAA

Antitoxin

Protein

• Length: 148 a.a.
• Molecular weight: 16447.89 Da
• Isoelectric Point: 9.9250

>AT116101 WP_129063402.1 NZ_CP034470:c195911-195468 [Pantoea agglomerans]
MKTFSFSANKTRPPRLWQAAGLNNADGVALLGQINEGLDGNVAHLIVSWAKITQNDLRKMSGIPSTTFSRSVKAKFSAEQ
SERLVRIIRVIDRAVELFEGDKDEALKWLNEPNRALSWKMPAELMASETGAYEVMKLITRLEHGVYS

Nucleotide

• Length: 444 bp

>AT116101 NZ_CP034470:c195911-195468 [Pantoea agglomerans]
ATGAAAACATTCAGCTTTTCTGCGAACAAAACCAGGCCGCCACGCTTATGGCAGGCCGCAGGCCTGAACAACGCTGATGG
TGTCGCCCTGCTCGGCCAGATTAATGAAGGCCTTGATGGCAACGTAGCTCACCTGATCGTCAGCTGGGCGAAGATTACGC
AAAACGACCTGCGCAAAATGTCCGGTATTCCCTCCACGACGTTCAGCCGAAGCGTGAAAGCGAAATTCAGCGCTGAACAA
AGTGAACGACTGGTACGTATTATCCGTGTCATTGATCGCGCAGTTGAACTGTTCGAAGGTGATAAGGATGAAGCGCTAAA
ATGGTTGAATGAGCCTAACAGGGCGCTGAGCTGGAAAATGCCCGCAGAACTGATGGCGTCTGAAACCGGGGCTTACGAGG
TCATGAAATTAATCACGCGCCTGGAGCACGGAGTTTATTCTTGA