Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1998018..1999579 Replicon chromosome
Accession NZ_CP034469
Organism Pantoea agglomerans strain CFSAN047153

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag D1628_RS09385 Protein ID WP_129062929.1
Coordinates 1998018..1999331 (-) Length 438 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag D1628_RS09390 Protein ID WP_061703948.1
Coordinates 1999331..1999579 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1628_RS09365 1993425..1993760 + 336 WP_129062927.1 gamma-glutamylcyclotransferase -
D1628_RS09370 1993993..1996038 - 2046 WP_010244891.1 FUSC family protein -
D1628_RS09375 1996114..1997535 - 1422 WP_129062928.1 M24 family metallopeptidase -
D1628_RS09380 1997707..1997913 - 207 WP_010244885.1 type II toxin-antitoxin system MqsA family antitoxin -
D1628_RS09385 1998018..1999331 - 1314 WP_129062929.1 type II toxin-antitoxin system HipA family toxin Toxin
D1628_RS09390 1999331..1999579 - 249 WP_061703948.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
D1628_RS09395 1999760..2000197 + 438 WP_061703947.1 GNAT family N-acetyltransferase -
D1628_RS09400 2000231..2001025 - 795 WP_061703946.1 inositol monophosphatase family protein -
D1628_RS09405 2001049..2002110 - 1062 WP_061703945.1 ABC transporter ATP-binding protein -
D1628_RS09410 2002107..2004332 - 2226 WP_061703944.1 iron ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(9-54)


Sequences

Toxin        


Download         Length: 438 a.a.        Molecular weight: 49113.72 Da        Isoelectric Point: 7.8460

>T116098 WP_129062929.1 NZ_CP034469:c1999331-1998018 [Pantoea agglomerans]
MQRLIAWMNGERVGVLTRQRNGAHEFQYDTGWLSNPLSRPLSLSMPLQVKALTSHAVINFFDNLLPDSPLIRDRIVARYQ
IKSCQPFDLLQEVGRDSVGATMLLPPDMPLPALQARYEVLDETRLESVLSAYQSDIPLGMLREETDFRISVAGAQEKTAL
LLTDEGWSIPAGATPTSHIIKLPIGEIKQPAATLDMRESVENEYLCLALARALGIDVPQATIIRAGQMRALAVERFDRRW
SRDKTRLIRLPQEDFCQALGLPSSTKYESDGGPGIVEIMQILMGSSNAIEDRYRFMMFQVFQWLIGATDGHAKNFSLFIE
RGGSYRLTPFYDVISAYPVLGGTGLNKRALKLAMGLRATKGKKTEIDKIFPRHFIATAKSVSFDRDSLQQIFDFFIKAFP
QAVVSVRDALPPDFPQHIADAIFSHSLIMLERLRQKE

Download         Length: 1314 bp

>T116098 NZ_CP034469:c1999331-1998018 [Pantoea agglomerans]
ATGCAAAGGCTGATTGCGTGGATGAACGGCGAGCGGGTAGGCGTACTCACCCGGCAGCGAAACGGCGCTCATGAGTTTCA
GTATGATACCGGCTGGCTGAGTAATCCGCTCTCCAGGCCGCTGTCACTTTCGATGCCGTTGCAGGTTAAGGCTCTCACCT
CACACGCCGTGATTAACTTCTTCGATAATCTGCTGCCGGATAGCCCATTGATTCGCGACAGAATCGTGGCGCGTTACCAG
ATTAAATCCTGTCAGCCGTTTGATCTGTTGCAGGAAGTGGGACGTGACAGCGTCGGGGCGACTATGCTGCTGCCGCCCGA
TATGCCACTGCCCGCACTGCAGGCCCGCTATGAAGTGCTGGATGAAACCCGGCTCGAAAGCGTGCTGTCGGCCTATCAGT
CAGATATCCCGCTGGGGATGCTGCGTGAAGAGACCGATTTCCGTATCTCGGTCGCGGGGGCGCAGGAGAAAACCGCACTG
CTGCTGACCGATGAAGGCTGGAGCATTCCTGCCGGTGCCACGCCCACCTCGCACATCATTAAGCTGCCGATCGGAGAGAT
TAAACAGCCGGCCGCGACGCTGGATATGCGTGAAAGTGTGGAGAATGAGTATCTCTGTCTGGCGCTGGCCCGTGCACTCG
GTATCGACGTGCCGCAGGCAACGATTATTCGTGCCGGACAGATGCGCGCCCTGGCGGTAGAACGTTTCGACCGCCGCTGG
TCACGCGATAAAACCCGGTTGATTCGCCTGCCGCAGGAGGATTTCTGTCAGGCGCTGGGACTGCCATCTTCAACCAAATA
TGAGTCGGATGGCGGGCCGGGCATTGTGGAGATCATGCAGATACTGATGGGATCGAGCAACGCCATCGAAGATCGCTATC
GCTTTATGATGTTCCAGGTGTTTCAGTGGCTGATTGGCGCAACTGACGGTCACGCCAAGAACTTCTCACTGTTTATTGAG
CGCGGTGGCAGTTATCGACTGACTCCCTTTTATGATGTGATCTCCGCTTACCCGGTACTGGGCGGCACCGGTCTGAACAA
GCGAGCGCTGAAACTGGCGATGGGTCTGCGTGCCACTAAGGGGAAGAAGACAGAAATCGATAAAATCTTCCCGCGCCATT
TTATCGCCACGGCAAAAAGCGTCAGTTTTGATCGTGACAGTTTGCAGCAGATCTTCGACTTCTTTATTAAGGCCTTTCCC
CAGGCAGTGGTCTCGGTGCGCGATGCTTTGCCGCCCGATTTCCCGCAGCACATCGCCGACGCCATCTTCAGTCATTCACT
CATTATGCTGGAGCGGCTACGGCAAAAAGAGTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9342.59 Da        Isoelectric Point: 5.5976

>AT116098 WP_061703948.1 NZ_CP034469:c1999579-1999331 [Pantoea agglomerans]
MIYSPLQLANRLKLIRQRNGWTQSELAKKVGLKQATISHFENAPDSTSLATLFKLLQSLELSLEVHEKEEAGAPQLHDED
EW

Download         Length: 249 bp

>AT116098 NZ_CP034469:c1999579-1999331 [Pantoea agglomerans]
ATGATATACAGCCCGCTACAGCTGGCAAACCGGCTAAAGCTCATTCGTCAGCGCAATGGCTGGACCCAGAGTGAGCTGGC
GAAAAAGGTCGGCCTGAAACAGGCCACCATCTCTCACTTTGAAAATGCCCCTGACAGTACCTCGCTGGCAACGCTGTTTA
AGCTGTTACAGTCGCTTGAGCTGAGTCTGGAAGTTCACGAGAAAGAGGAGGCCGGTGCGCCTCAGCTGCATGATGAGGAT
GAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References