Detailed information of TA system TA116097

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 1902125..1902788
• Replicon: chromosome
• Accession: NZ_CP034469
• Organism: Pantoea agglomerans strain CFSAN047153

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: D1628_RS08920
• Protein ID: WP_071998040.1
• Coordinates: 1902125..1902439 (+)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: D1628_RS08925
• Protein ID: WP_033757561.1
• Coordinates: 1902432..1902788 (+)
• Length: 119 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1628_RS08900	1897547..1898944	+	1398	WP_010245332.1	class II fumarate hydratase	-
D1628_RS08905	1898988..1899917	-	930	WP_033757557.1	DNA replication terminus site-binding protein	-
D1628_RS08910	1900120..1901304	+	1185	WP_033787932.1	MFS transporter	-
D1628_RS08915	1901512..1902006	+	495	WP_010245324.1	Rrf2 family transcriptional regulator	-
D1628_RS08920	1902125..1902439	+	315	WP_071998040.1	type II toxin-antitoxin system HicA family toxin	Toxin
D1628_RS08925	1902432..1902788	+	357	WP_033757561.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
D1628_RS08930	1902874..1906026	-	3153	WP_031593601.1	multidrug efflux RND transporter permease subunit OqxB	-
D1628_RS08935	1906039..1907193	-	1155	WP_022625698.1	efflux RND transporter periplasmic adaptor subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (41-90)

Antitoxin

• Uncharacterised protein family HicB (59-111)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 11931.69 Da
• Isoelectric Point: 9.9846

>T116097 WP_071998040.1 NZ_CP034469:1902125-1902439 [Pantoea agglomerans]
MTSLDEVAEVRMNTVVRELRKKHRETLEQVFQMPPPSGLKWQAVESLIRALGGEIKEGSGSRVRFLLRGRIARFHRPHPS
PDTDRGAVINLREWLESIGVDPYE

Nucleotide

• Length: 315 bp

>T116097 NZ_CP034469:1902125-1902439 [Pantoea agglomerans]
ATGACTTCACTGGATGAAGTCGCGGAGGTCAGGATGAACACCGTTGTCAGGGAGTTACGGAAAAAACATCGTGAAACGTT
GGAGCAGGTTTTTCAAATGCCGCCGCCGTCCGGACTGAAATGGCAGGCAGTTGAGTCATTAATCAGGGCTCTGGGTGGTG
AGATTAAAGAAGGCAGTGGTTCACGGGTGCGATTTCTTCTCAGAGGAAGAATAGCGCGTTTTCACCGGCCGCATCCTTCG
CCAGACACCGACAGAGGGGCTGTTATTAATCTGCGTGAATGGCTGGAAAGTATTGGAGTCGATCCCTATGAATAA

Antitoxin

Protein

• Length: 119 a.a.
• Molecular weight: 13250.86 Da
• Isoelectric Point: 4.8896

>AT116097 WP_033757561.1 NZ_CP034469:1902432-1902788 [Pantoea agglomerans]
MNNRSNSSITVAGQPAVITYVPELNMFRGRFTGLSGYCDFVSDSVQGLYKEGEISLREYLEDCAASGINPYAEQEKIKTF
TLRYPESLGERLSQAAAQNETSLNAFIIETLNERLKRR

Nucleotide

• Length: 357 bp

>AT116097 NZ_CP034469:1902432-1902788 [Pantoea agglomerans]
ATGAATAATCGTTCAAATTCATCAATCACCGTCGCTGGTCAACCCGCTGTGATCACCTATGTTCCTGAACTCAACATGTT
CCGTGGGCGTTTTACTGGCCTGTCAGGCTACTGTGATTTTGTCTCTGACAGCGTACAGGGGCTGTACAAAGAGGGCGAGA
TTTCGTTGCGCGAATACCTGGAAGATTGTGCAGCCTCCGGCATTAATCCCTATGCTGAGCAGGAAAAAATTAAGACCTTT
ACGCTGCGCTATCCTGAATCGCTGGGAGAGCGCCTGTCTCAGGCTGCCGCGCAAAATGAAACCTCGCTGAATGCGTTTAT
CATTGAAACGCTGAATGAAAGATTGAAGCGGCGCTAG