Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 761242..761873 Replicon chromosome
Accession NZ_CP034469
Organism Pantoea agglomerans strain CFSAN047153

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag D1628_RS03405 Protein ID WP_072008743.1
Coordinates 761242..761421 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A8X8DTB6
Locus tag D1628_RS03410 Protein ID WP_010253955.1
Coordinates 761448..761873 (+) Length 142 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1628_RS03395 757573..759474 + 1902 WP_039386527.1 pyruvate dehydrogenase complex dihydrolipoyllysine-residue acetyltransferase -
D1628_RS03400 759635..761059 + 1425 WP_010253950.1 dihydrolipoyl dehydrogenase -
D1628_RS03405 761242..761421 + 180 WP_072008743.1 type II toxin-antitoxin system HicA family toxin Toxin
D1628_RS03410 761448..761873 + 426 WP_010253955.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
D1628_RS03415 761955..762095 + 141 WP_033770968.1 CRISPR-associated protein Cas1 -
D1628_RS03420 762280..763209 + 930 WP_033770970.1 Rpn family recombination-promoting nuclease/putative transposase -
D1628_RS03425 763638..764537 - 900 WP_033770972.1 LysR family transcriptional regulator -
D1628_RS03430 764643..765152 + 510 WP_010253965.1 phenolic acid decarboxylase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 60 a.a.        Molecular weight: 6635.76 Da        Isoelectric Point: 11.3688

>T116095 WP_072008743.1 NZ_CP034469:761242-761421 [Pantoea agglomerans]
MDRSTLISEMKADGWVLTRINGSHHHFTHPTKPGLVTVPHPKKDLPIGTVKSIRKQARI

Download         Length: 180 bp

>T116095 NZ_CP034469:761242-761421 [Pantoea agglomerans]
ATGGATCGCAGCACGTTAATTTCCGAAATGAAGGCTGATGGCTGGGTTCTGACAAGGATAAACGGTAGCCATCACCATTT
CACACATCCGACAAAACCGGGGCTGGTTACAGTACCCCATCCTAAAAAAGACTTACCGATCGGTACGGTAAAGAGCATCA
GGAAACAAGCGAGAATTTAA

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15422.60 Da        Isoelectric Point: 4.7662

>AT116095 WP_010253955.1 NZ_CP034469:761448-761873 [Pantoea agglomerans]
MFYPIAIEAGDHEHAYGVIVPDLPGCFSAGDTLDEAIKNAKEAITGHIELCVELGHEIPAVSTIETLATNPDYQGYIWAL
VDVDVIRLLGGSEKINVTLPRSLIDRIDRCVASHPEYKSRSGFLAQVALERITAPINRPQK

Download         Length: 426 bp

>AT116095 NZ_CP034469:761448-761873 [Pantoea agglomerans]
ATGTTTTATCCAATCGCGATTGAAGCGGGTGATCACGAACACGCATACGGCGTAATCGTTCCCGATTTACCAGGGTGTTT
CTCTGCCGGGGATACTCTTGATGAAGCCATTAAAAACGCCAAAGAGGCTATCACAGGGCATATCGAATTATGTGTAGAGC
TCGGTCATGAGATCCCTGCCGTGTCCACCATTGAGACTCTGGCCACGAATCCTGACTATCAGGGTTATATCTGGGCATTG
GTTGATGTAGATGTCATTCGTTTGCTGGGCGGCTCTGAAAAAATCAATGTCACTTTACCCAGGTCGTTAATTGATCGGAT
TGATCGTTGTGTGGCTTCACACCCGGAATACAAAAGTCGCTCGGGCTTTCTGGCTCAGGTAGCGCTTGAGCGTATTACTG
CTCCGATTAACAGGCCTCAAAAGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References