Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/HicA-HicB |
Location | 761242..761873 | Replicon | chromosome |
Accession | NZ_CP034469 | ||
Organism | Pantoea agglomerans strain CFSAN047153 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | - |
Locus tag | D1628_RS03405 | Protein ID | WP_072008743.1 |
Coordinates | 761242..761421 (+) | Length | 60 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | A0A8X8DTB6 |
Locus tag | D1628_RS03410 | Protein ID | WP_010253955.1 |
Coordinates | 761448..761873 (+) | Length | 142 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
D1628_RS03395 | 757573..759474 | + | 1902 | WP_039386527.1 | pyruvate dehydrogenase complex dihydrolipoyllysine-residue acetyltransferase | - |
D1628_RS03400 | 759635..761059 | + | 1425 | WP_010253950.1 | dihydrolipoyl dehydrogenase | - |
D1628_RS03405 | 761242..761421 | + | 180 | WP_072008743.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
D1628_RS03410 | 761448..761873 | + | 426 | WP_010253955.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
D1628_RS03415 | 761955..762095 | + | 141 | WP_033770968.1 | CRISPR-associated protein Cas1 | - |
D1628_RS03420 | 762280..763209 | + | 930 | WP_033770970.1 | Rpn family recombination-promoting nuclease/putative transposase | - |
D1628_RS03425 | 763638..764537 | - | 900 | WP_033770972.1 | LysR family transcriptional regulator | - |
D1628_RS03430 | 764643..765152 | + | 510 | WP_010253965.1 | phenolic acid decarboxylase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 60 a.a. Molecular weight: 6635.76 Da Isoelectric Point: 11.3688
>T116095 WP_072008743.1 NZ_CP034469:761242-761421 [Pantoea agglomerans]
MDRSTLISEMKADGWVLTRINGSHHHFTHPTKPGLVTVPHPKKDLPIGTVKSIRKQARI
MDRSTLISEMKADGWVLTRINGSHHHFTHPTKPGLVTVPHPKKDLPIGTVKSIRKQARI
Download Length: 180 bp
>T116095 NZ_CP034469:761242-761421 [Pantoea agglomerans]
ATGGATCGCAGCACGTTAATTTCCGAAATGAAGGCTGATGGCTGGGTTCTGACAAGGATAAACGGTAGCCATCACCATTT
CACACATCCGACAAAACCGGGGCTGGTTACAGTACCCCATCCTAAAAAAGACTTACCGATCGGTACGGTAAAGAGCATCA
GGAAACAAGCGAGAATTTAA
ATGGATCGCAGCACGTTAATTTCCGAAATGAAGGCTGATGGCTGGGTTCTGACAAGGATAAACGGTAGCCATCACCATTT
CACACATCCGACAAAACCGGGGCTGGTTACAGTACCCCATCCTAAAAAAGACTTACCGATCGGTACGGTAAAGAGCATCA
GGAAACAAGCGAGAATTTAA
Antitoxin
Download Length: 142 a.a. Molecular weight: 15422.60 Da Isoelectric Point: 4.7662
>AT116095 WP_010253955.1 NZ_CP034469:761448-761873 [Pantoea agglomerans]
MFYPIAIEAGDHEHAYGVIVPDLPGCFSAGDTLDEAIKNAKEAITGHIELCVELGHEIPAVSTIETLATNPDYQGYIWAL
VDVDVIRLLGGSEKINVTLPRSLIDRIDRCVASHPEYKSRSGFLAQVALERITAPINRPQK
MFYPIAIEAGDHEHAYGVIVPDLPGCFSAGDTLDEAIKNAKEAITGHIELCVELGHEIPAVSTIETLATNPDYQGYIWAL
VDVDVIRLLGGSEKINVTLPRSLIDRIDRCVASHPEYKSRSGFLAQVALERITAPINRPQK
Download Length: 426 bp
>AT116095 NZ_CP034469:761448-761873 [Pantoea agglomerans]
ATGTTTTATCCAATCGCGATTGAAGCGGGTGATCACGAACACGCATACGGCGTAATCGTTCCCGATTTACCAGGGTGTTT
CTCTGCCGGGGATACTCTTGATGAAGCCATTAAAAACGCCAAAGAGGCTATCACAGGGCATATCGAATTATGTGTAGAGC
TCGGTCATGAGATCCCTGCCGTGTCCACCATTGAGACTCTGGCCACGAATCCTGACTATCAGGGTTATATCTGGGCATTG
GTTGATGTAGATGTCATTCGTTTGCTGGGCGGCTCTGAAAAAATCAATGTCACTTTACCCAGGTCGTTAATTGATCGGAT
TGATCGTTGTGTGGCTTCACACCCGGAATACAAAAGTCGCTCGGGCTTTCTGGCTCAGGTAGCGCTTGAGCGTATTACTG
CTCCGATTAACAGGCCTCAAAAGTAA
ATGTTTTATCCAATCGCGATTGAAGCGGGTGATCACGAACACGCATACGGCGTAATCGTTCCCGATTTACCAGGGTGTTT
CTCTGCCGGGGATACTCTTGATGAAGCCATTAAAAACGCCAAAGAGGCTATCACAGGGCATATCGAATTATGTGTAGAGC
TCGGTCATGAGATCCCTGCCGTGTCCACCATTGAGACTCTGGCCACGAATCCTGACTATCAGGGTTATATCTGGGCATTG
GTTGATGTAGATGTCATTCGTTTGCTGGGCGGCTCTGAAAAAATCAATGTCACTTTACCCAGGTCGTTAATTGATCGGAT
TGATCGTTGTGTGGCTTCACACCCGGAATACAAAAGTCGCTCGGGCTTTCTGGCTCAGGTAGCGCTTGAGCGTATTACTG
CTCCGATTAACAGGCCTCAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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