Detailed information of TA system TA116093

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 6756591..6757116
• Replicon: chromosome
• Accession: NZ_CP034463
• Organism: Streptomyces aquilus strain GGCR-6

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: EJC51_RS31280
• Protein ID: WP_126274135.1
• Coordinates: 6756591..6756854 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: EJC51_RS31285
• Protein ID: WP_126274136.1
• Coordinates: 6756847..6757116 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EJC51_RS31260	6752837..6753838	+	1002	WP_126274132.1	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-
EJC51_RS31265	6753868..6754611	+	744	WP_126274133.1	ROK family protein	-
EJC51_RS31270	6754637..6755176	-	540	WP_126274134.1	hypothetical protein	-
EJC51_RS31275	6755368..6756456	+	1089	WP_097268539.1	redox-regulated ATPase YchF	-
EJC51_RS31280	6756591..6756854	-	264	WP_126274135.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EJC51_RS31285	6756847..6757116	-	270	WP_126274136.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
EJC51_RS31290	6757161..6757742	-	582	WP_126274137.1	Uma2 family endonuclease	-
EJC51_RS31295	6758065..6758781	+	717	WP_126274138.1	response regulator transcription factor	-
EJC51_RS31300	6758713..6759372	-	660	WP_126274139.1	TetR/AcrR family transcriptional regulator	-
EJC51_RS31305	6759729..6761243	+	1515	WP_126274140.1	MFS transporter	-
EJC51_RS31310	6761306..6761953	+	648	WP_166682921.1	TcmI family type II polyketide cyclase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-58)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10059.49 Da
• Isoelectric Point: 7.3183

>T116093 WP_126274135.1 NZ_CP034463:c6756854-6756591 [Streptomyces aquilus]
VSEYRTVFRPEAQAELRKIPRDMALRILAKLTELESDPLGFDTTALVSQPERRRLRVGDHRVVYTIDNGELVVWVVHVEH
RSTVYGT

Nucleotide

• Length: 264 bp

>T116093 NZ_CP034463:c6756854-6756591 [Streptomyces aquilus]
GTGAGTGAGTATCGGACCGTCTTCCGACCGGAGGCGCAGGCCGAGCTTCGGAAGATCCCTCGCGACATGGCGCTGCGCAT
CCTGGCCAAGCTGACCGAACTGGAGAGCGATCCCCTCGGGTTCGACACCACCGCGCTCGTGTCGCAGCCGGAACGCCGCC
GGCTGCGAGTCGGCGACCACCGGGTCGTCTACACGATCGACAACGGAGAGCTCGTGGTGTGGGTCGTCCATGTGGAACAC
AGGTCTACCGTTTACGGGACCTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10275.71 Da
• Isoelectric Point: 4.7777

>AT116093 WP_126274136.1 NZ_CP034463:c6757116-6756847 [Streptomyces aquilus]
MTRPLPTESIRDVRAHLAEVVERADRDDVPTVITRRGKEVAAVVSIEVLRKYQEWEEREINRIIDERMANPAPGIPIEDI
MRETLARGE

Nucleotide

• Length: 270 bp

>AT116093 NZ_CP034463:c6757116-6756847 [Streptomyces aquilus]
ATGACGCGGCCGCTGCCCACAGAGTCCATCCGCGACGTGCGCGCCCACCTGGCGGAAGTCGTGGAGCGTGCGGACCGCGA
CGACGTACCCACGGTCATCACGCGCCGGGGCAAGGAAGTCGCCGCCGTCGTCTCCATCGAGGTGCTGCGCAAGTACCAGG
AGTGGGAAGAGCGCGAGATCAACCGGATCATCGACGAGCGCATGGCCAACCCGGCACCCGGCATCCCGATCGAGGACATC
ATGAGGGAGACGCTGGCGCGCGGTGAGTGA