Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 6737372..6737984 Replicon chromosome
Accession NZ_CP034449
Organism Mesorhizobium sp. M2A.F.Ca.ET.046.03.2.1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag EJ072_RS32235 Protein ID WP_126083820.1
Coordinates 6737372..6737557 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag EJ072_RS32240 Protein ID WP_126082863.1
Coordinates 6737586..6737984 (+) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJ072_RS32205 6732766..6733110 - 345 WP_126082857.1 cupin domain-containing protein -
EJ072_RS32210 6733112..6734392 - 1281 WP_126082858.1 O-acetylhomoserine aminocarboxypropyltransferase -
EJ072_RS32215 6734553..6735074 - 522 WP_126082859.1 CoA-binding protein -
EJ072_RS32220 6735071..6735853 - 783 WP_126082860.1 AAA family ATPase -
EJ072_RS32225 6735898..6736719 - 822 WP_126082861.1 enoyl-CoA hydratase -
EJ072_RS32230 6736872..6737327 + 456 WP_126082862.1 PaaI family thioesterase -
EJ072_RS32235 6737372..6737557 + 186 WP_126083820.1 type II toxin-antitoxin system HicA family toxin Toxin
EJ072_RS32240 6737586..6737984 + 399 WP_126082863.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EJ072_RS32245 6738252..6738716 + 465 WP_040983169.1 50S ribosomal protein L13 -
EJ072_RS32250 6738716..6739186 + 471 WP_040999876.1 30S ribosomal protein S9 -
EJ072_RS32255 6739245..6740153 - 909 WP_126082864.1 LysR family transcriptional regulator -
EJ072_RS32260 6740248..6741120 + 873 WP_126082865.1 aldo/keto reductase family oxidoreductase -
EJ072_RS32265 6741327..6742385 - 1059 WP_126082866.1 glycerophosphodiester phosphodiesterase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-124)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6953.13 Da        Isoelectric Point: 11.7888

>T116087 WP_126083820.1 NZ_CP034449:6737372-6737557 [Mesorhizobium sp. M2A.F.Ca.ET.046.03.2.1]
IERDSRRIIKRLRDDGFELVSVRGSHHKFRKGAIVLVVPHPEKDLPVGTARAIAKQAGWIR

Download         Length: 186 bp

>T116087 NZ_CP034449:6737372-6737557 [Mesorhizobium sp. M2A.F.Ca.ET.046.03.2.1]
ATCGAGCGTGACAGCCGCCGCATCATAAAGCGGCTGAGAGACGACGGCTTCGAATTGGTCTCAGTTCGGGGCTCGCATCA
CAAATTCCGGAAAGGCGCCATCGTGCTTGTCGTTCCGCACCCGGAAAAAGATCTGCCAGTCGGCACTGCTCGCGCGATCG
CCAAACAGGCAGGCTGGATTCGCTAG

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14273.10 Da        Isoelectric Point: 4.4194

>AT116087 WP_126082863.1 NZ_CP034449:6737586-6737984 [Mesorhizobium sp. M2A.F.Ca.ET.046.03.2.1]
MKNYFALVEKDADSAFGIRFPDIPGCFSAADVPEDIVPNAIEALQLWAEDMSVPEPSSHEAIVSLADIRTALSEGAYLVS
VPLIDNDSAVVRANVTFERGVLRAIDAAARERGITRSAFLSSAARREIEAKH

Download         Length: 399 bp

>AT116087 NZ_CP034449:6737586-6737984 [Mesorhizobium sp. M2A.F.Ca.ET.046.03.2.1]
ATGAAGAACTACTTCGCGCTGGTTGAGAAGGATGCCGACAGCGCATTTGGTATTCGCTTCCCCGACATTCCGGGCTGTTT
TTCAGCGGCCGATGTACCCGAGGATATCGTGCCGAATGCAATCGAGGCCCTGCAACTTTGGGCCGAGGATATGTCCGTGC
CTGAACCCTCCAGCCATGAGGCGATTGTATCGCTTGCCGATATCCGTACCGCGCTATCTGAAGGAGCTTATCTGGTCTCC
GTGCCGCTGATCGACAATGACAGTGCCGTGGTCAGGGCGAACGTGACATTCGAACGCGGTGTCCTGCGCGCAATCGATGC
CGCCGCGCGCGAGCGCGGCATCACCAGGTCCGCATTTCTCTCAAGCGCCGCCCGCAGGGAAATTGAGGCAAAGCACTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References