Detailed information of TA system TA116086

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicA
• Location: 6263716..6264127
• Replicon: chromosome
• Accession: NZ_CP034449
• Organism: Mesorhizobium sp. M2A.F.Ca.ET.046.03.2.1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: EJ072_RS29855
• Protein ID: WP_126082529.1
• Coordinates: 6263927..6264127 (-)
• Length: 67 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: EJ072_RS29850
• Protein ID: WP_126082528.1
• Coordinates: 6263716..6263922 (-)
• Length: 69 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EJ072_RS29820	6259046..6259831	+	786	WP_126082522.1	phosphodiester glycosidase family protein	-
EJ072_RS29825	6259859..6260830	-	972	WP_126082523.1	Tim44 domain-containing protein	-
EJ072_RS29830	6261139..6262260	+	1122	WP_126082524.1	glycoside hydrolase family 25 protein	-
EJ072_RS29835	6262281..6262475	-	195	WP_126082525.1	hypothetical protein	-
EJ072_RS29840	6262503..6262955	-	453	WP_126082526.1	pyridoxamine 5'-phosphate oxidase family protein	-
EJ072_RS29845	6263304..6263675	-	372	WP_126082527.1	VOC family protein	-
EJ072_RS29850	6263716..6263922	-	207	WP_126082528.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
EJ072_RS29855	6263927..6264127	-	201	WP_126082529.1	type II toxin-antitoxin system HicA family toxin	Toxin
EJ072_RS29860	6264136..6267912	-	3777	WP_126082530.1	vitamin B12-dependent ribonucleotide reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (8-64)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-66)

Sequences

Toxin

Protein

• Length: 67 a.a.
• Molecular weight: 7328.57 Da
• Isoelectric Point: 10.7459

>T116086 WP_126082529.1 NZ_CP034449:c6264127-6263927 [Mesorhizobium sp. M2A.F.Ca.ET.046.03.2.1]
MPPRLTVREVIRMLEADGWYLVATKGSHRQYKHKIKAGRVTVAGKPSEEVAPGTLNSILKQSGLKE

Nucleotide

• Length: 201 bp

>T116086 NZ_CP034449:c6264127-6263927 [Mesorhizobium sp. M2A.F.Ca.ET.046.03.2.1]
ATGCCGCCCCGGCTTACGGTCCGCGAAGTAATTCGCATGCTGGAGGCCGACGGTTGGTATCTGGTTGCAACCAAAGGCAG
CCATCGCCAATATAAGCACAAAATCAAAGCCGGCCGCGTCACCGTGGCCGGCAAGCCGTCTGAAGAGGTTGCGCCAGGAA
CGCTGAACAGCATTCTCAAGCAGTCCGGCTTAAAGGAGTGA

Antitoxin

Protein

• Length: 69 a.a.
• Molecular weight: 7320.32 Da
• Isoelectric Point: 4.3178

>AT116086 WP_126082528.1 NZ_CP034449:c6263922-6263716 [Mesorhizobium sp. M2A.F.Ca.ET.046.03.2.1]
MRYAVVIEKAGSNFSAYVPDLPGCIATGATVPEVENEIRDAIRFHIEGLRADGLEVPKAVSLAEYVEA

Nucleotide

• Length: 207 bp

>AT116086 NZ_CP034449:c6263922-6263716 [Mesorhizobium sp. M2A.F.Ca.ET.046.03.2.1]
ATGCGCTACGCGGTGGTGATCGAAAAAGCCGGAAGCAACTTTTCCGCATATGTTCCTGACCTGCCAGGCTGCATCGCGAC
AGGTGCAACAGTGCCTGAAGTGGAGAACGAAATCCGCGACGCAATTCGTTTCCACATAGAGGGTCTGCGCGCCGATGGGC
TGGAAGTTCCCAAGGCAGTCAGTCTCGCTGAGTATGTTGAAGCATAG