Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-Phd
Location 3371544..3372199 Replicon chromosome
Accession NZ_CP034449
Organism Mesorhizobium sp. M2A.F.Ca.ET.046.03.2.1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EJ072_RS16235 Protein ID WP_126080570.1
Coordinates 3371544..3371945 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag EJ072_RS16240 Protein ID WP_126080571.1
Coordinates 3371945..3372199 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EJ072_RS16215 3367017..3368051 - 1035 WP_126080566.1 aldo/keto reductase -
EJ072_RS16220 3368089..3369276 - 1188 WP_126080567.1 MFS transporter -
EJ072_RS16225 3369398..3370303 + 906 WP_126080568.1 LysR family transcriptional regulator -
EJ072_RS16230 3370365..3371414 - 1050 WP_126080569.1 aldo/keto reductase -
EJ072_RS16235 3371544..3371945 - 402 WP_126080570.1 type II toxin-antitoxin system VapC family toxin Toxin
EJ072_RS16240 3371945..3372199 - 255 WP_126080571.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EJ072_RS16245 3372284..3372946 - 663 WP_126080572.1 YggS family pyridoxal phosphate-dependent enzyme -
EJ072_RS16250 3373163..3375790 + 2628 WP_126080573.1 leucine--tRNA ligase -
EJ072_RS16255 3375777..3376358 + 582 WP_126080574.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-61)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14794.05 Da        Isoelectric Point: 5.9036

>T116085 WP_126080570.1 NZ_CP034449:c3371945-3371544 [Mesorhizobium sp. M2A.F.Ca.ET.046.03.2.1]
MYLLDTNVVSDVQRRLPKPTAWIASIDPASINLSVITLGEIERGIVKQRKIDPERAARLDIWLRELRRDNTDRILAITEE
VALAWGRITAGRTRGSADSLIAATALVHDLILVTRNVADFEGVGVTVLNPWEV

Download         Length: 402 bp

>T116085 NZ_CP034449:c3371945-3371544 [Mesorhizobium sp. M2A.F.Ca.ET.046.03.2.1]
ATGTATCTGCTGGACACGAACGTCGTGTCGGACGTGCAAAGACGGTTGCCTAAGCCGACTGCCTGGATAGCTTCGATTGA
TCCGGCGTCGATCAACCTTAGTGTCATTACGCTGGGTGAGATCGAGCGAGGAATCGTCAAACAGCGTAAGATCGACCCTG
AAAGGGCGGCTCGGCTCGATATCTGGCTGCGAGAACTTCGAAGAGACAATACGGACCGCATTCTCGCGATCACGGAGGAG
GTCGCTCTTGCCTGGGGTCGCATAACGGCGGGACGCACACGGGGGAGCGCCGACTCGCTTATCGCGGCGACCGCCCTCGT
GCACGACCTGATCCTGGTCACGCGAAACGTCGCCGACTTCGAGGGCGTCGGCGTTACAGTCCTCAATCCCTGGGAAGTCT
GA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9634.81 Da        Isoelectric Point: 5.8561

>AT116085 WP_126080571.1 NZ_CP034449:c3372199-3371945 [Mesorhizobium sp. M2A.F.Ca.ET.046.03.2.1]
MNWHLQDAKNNFSKVVQRARTEGPQTVTLRGERAAVVLSADDYDRLAGKKKSLVEYLLSGPGWDEEFDKEITRRSDTIIR
DIDL

Download         Length: 255 bp

>AT116085 NZ_CP034449:c3372199-3371945 [Mesorhizobium sp. M2A.F.Ca.ET.046.03.2.1]
ATGAACTGGCATCTTCAGGACGCGAAGAACAATTTCTCGAAAGTGGTCCAGCGGGCGCGAACCGAGGGACCGCAGACCGT
GACACTTCGCGGCGAACGTGCCGCGGTCGTCCTCTCCGCAGACGACTACGATCGCTTGGCCGGGAAGAAGAAATCGCTCG
TCGAGTACCTATTGAGCGGTCCAGGTTGGGACGAGGAGTTTGACAAGGAAATCACCCGTCGCTCGGACACGATTATCCGG
GACATTGATCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References